Search Results - "Chen, Barbara B." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase

Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase

by Penning, Thomas D, Chandrakumar, Nizal S, Chen, Barbara B, Chen, Helen Y, Desai, Bipin N, Djuric, Stevan W, Docter, Stephen H, Gasiecki, Alan F, Haack, Richard A, Miyashiro, Julie M, Russell, Mark A, Yu, Stella S, Corley, David G, Durley, Richard C, Kilpatrick, Brian F, Parnas, Barry L, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Krivi, Gwen G, Villani-Price, Doreen, Pyla, E. Yvonne, Smith, Walter G, Ghoreishi-Haack, Nayereh S
Published in Journal of medicinal chemistry (24.02.2000)

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Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists

Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists

by PENNING, Thomas D, KHILEVICH, Albert, HANNEKE, Melanie L, KEENE, Jeffery L, KLOVER, Jon A, NICKOLS, G. Allen, NICKOLS, Maureen A, RADER, Randall K, SETTLE, Steven L, SHANNON, Kristen E, STEININGER, Christina N, WESTLIN, Marisa M, CHEN, Barbara B, WESTLIN, William F, RUSSELL, Mark A, BOYS, Mark L, YAPING WANG, DUFFIN, Tiffany, ENGLEMAN, V. Wayne, FINN, Mary Beth, FREEMAN, Sandra K
Published in Bioorganic & medicinal chemistry letters (15.06.2006)

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Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists

Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists

by BOYS, Mark L, SCHRETZMAN, Lori A, STENMARK, Heather G, HONGWEI WU, SPANGLER, Dale P, CLARE, Michael, DESAI, Bipin N, KHANNA, Ish K, NGUYEN, Maria N, DUFFIN, Tiffany, WAYNE ENGLEMAN, V, FINN, Mary Beth, CHANDRAKUMAR, Nizal S, FREEMAN, Sandra K, HANNEKE, Melanie L, KEENE, Jeffery L, KLOVER, Jon A, NICKOLS, G. Allen, NICKOLS, Maureen A, STEININGER, Christina N, WESTLIN, Marisa, WESTLIN, William, YU, Yi X, TOLLEFSON, Michael B, YAPING WANG, DALTON, Christopher R, NORRING, Sarah A, MOHLER, Scott B, DOWNS, Victoria L, PENNING, Thomas D, RUSSELL, Mark A, WENDT, John A, CHEN, Barbara B
Published in Bioorganic & medicinal chemistry letters (15.02.2006)

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Discovery of + (2 -{4 -[2 -(5,6,7,8 -tetrahydro -1,8 -naphthyridin -2-yl )ethoxy ]phenyl} -cyclopropyl )acetic acid as potent and selective αvβ3 inhibitor : Design, synthesis, and optimization

Discovery of + (2 -{4 -[2 -(5,6,7,8 -tetrahydro -1,8 -naphthyridin -2-yl )ethoxy ]phenyl} -cyclopropyl )acetic acid as potent and selective αvβ3 inhibitor : Design, synthesis, and optimization

by NAGARAJAN, Srinivasan R, LU, Hwang-Fun, KEENE, Jeffery L, DUFFIN, Tiffany, ENGLEMAN, V. Wayne, FINN, Mary B, FREEMAN, Sandra K, KLOVER, Jon A, NICKOLS, G. Alan, NICKOLS, Maureen A, SHANNON, Kristen E, STEININGER, Christina A, GASIECKI, Alan F, WESTLIN, William F, WESTLIN, Marisa M, WILLIAMS, Melanie L, KHANNA, Ish K, PARIKH, Mihir D, DESAI, Bipinchandra N, ROGERS, Thomas E, CLARE, Michael, CHEN, Barbara B, RUSSELL, Mark A
Published in Bioorganic & medicinal chemistry (15.05.2007)

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Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties

Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties

by WENDT, John A, HONGWEI WU, KEENE, Jeffery L, WAYNE ENGLEMAN, V, FREEMAN, Sandra K, HANNEKE, Melanie L, SHANNON, Kristen E, NICKOLS, Maureen A, STEININGER, Christina N, WESTLIN, Marissa, KLOVER, Jon A, WESTLIN, William, STENMARK, Heather G, NICKOLS, G. Allen, RUSSELL, Mark A, BOYS, Mark L, DOWNS, Victoria L, PENNING, Thomas D, CHEN, Barbara B, YAPING WANG, DUFFIN, Tiffany, FINN, Mary Beth
Published in Bioorganic & medicinal chemistry letters (15.02.2006)

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Synthesis of cinnamic acids and related isosteres as potent and selective αvβ3 receptor antagonists

Synthesis of cinnamic acids and related isosteres as potent and selective αvβ3 receptor antagonists

by Penning, Thomas D., Russell, Mark A., Chen, Barbara B., Chen, Helen Y., Desai, Bipin N., Docter, Stephen H., Edwards, David J., Gesicki, Glen J., Liang, Chi-Dean, Malecha, James W., Yu, Stella S., Engleman, V.Wayne, Freeman, Sandra K., Hanneke, Melanie L., Shannon, Kristen E., Westlin, Marisa M., Nickols, G.Allen
Published in Bioorganic & medicinal chemistry letters (22.03.2004)

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Synthesis of Potent Leukotriene A4 Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid

Synthesis of Potent Leukotriene A4 Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid

by Penning, Thomas D, Russell, Mark A, Chen, Barbara B, Chen, Helen Y, Liang, Chi-Dean, Mahoney, Matthew W, Malecha, James W, Miyashiro, Julie M, Yu, Stella S, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Villani-Price, Doreen, Pyla, E. Yvonne, Ghoreishi-Haack, Nayereh S, Smith, Walter G
Published in Journal of medicinal chemistry (01.08.2002)

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Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization

by Nagarajan, Srinivasan R, Lu, Hwang-Fun, Gasiecki, Alan F, Khanna, Ish K, Parikh, Mihir D, Desai, Bipinchandra N, Rogers, Thomas E, Clare, Michael, Chen, Barbara B, Russell, Mark A, Keene, Jeffery L, Duffin, Tiffany, Engleman, V Wayne, Finn, Mary B, Freeman, Sandra K, Klover, Jon A, Nickols, G Alan, Nickols, Maureen A, Shannon, Kristen E, Steininger, Christina A, Westlin, William F, Westlin, Marisa M, Williams, Melanie L
Published in Bioorganic & medicinal chemistry (15.05.2007)

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Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective α vβ 3 inhibitor: Design, synthesis, and optimization

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective α vβ 3 inhibitor: Design, synthesis, and optimization

by Nagarajan, Srinivasan R., Lu, Hwang-Fun, Gasiecki, Alan F., Khanna, Ish K., Parikh, Mihir D., Desai, Bipinchandra N., Rogers, Thomas E., Clare, Michael, Chen, Barbara B., Russell, Mark A., Keene, Jeffery L., Duffin, Tiffany, Engleman, V. Wayne, Finn, Mary B., Freeman, Sandra K., Klover, Jon A., Nickols, G. Alan, Nickols, Maureen A., Shannon, Kristen E., Steininger, Christina A., Westlin, William F., Westlin, Marisa M., Williams, Melanie L.
Published in Bioorganic & medicinal chemistry (2007)

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Synthesis of potent leukotriene A(4) hydrolase inhibitors. identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid

Synthesis of potent leukotriene A(4) hydrolase inhibitors. identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid

by Penning, TD, Russell, MA, Chen, BB, Chen, HY, Liang, CD, Mahoney, MW, Malecha, JW, Miyashiro, JM, Yu, SS, Askonas, LJ, Gierse, JK, Harding, EI, Highkin, MK, Kachur, JF, Kim, SH, Villani-Price, D, Pyla, EY, Ghoreishi-Haack, NS, Smith, WG
Published in Journal of medicinal chemistry (01.08.2002)

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Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists

Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists

by Penning, Thomas D, Khilevich, Albert, Chen, Barbara B, Russell, Mark A, Boys, Mark L, Wang, Yaping, Duffin, Tiffany, Engleman, V Wayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, G Allen, Nickols, Maureen A, Rader, Randall K, Settle, Steven L, Shannon, Kristen E, Steininger, Christina N, Westlin, Marisa M, Westlin, William F
Published in Bioorganic & medicinal chemistry letters (15.06.2006)

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Synthesis of pyrazoles and isoxazoles as potent alpha sub(v) beta sub(3) receptor antagonists

Synthesis of pyrazoles and isoxazoles as potent alpha sub(v) beta sub(3) receptor antagonists

by Penning, Thomas D, Khilevich, Albert, Chen, Barbara B, Russell, Mark A, Boys, Mark L, Wang, Yaping, Duffin, Tiffany, Engleman, VWayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, GAllen, Nickols, Maureen A, Rader, Randall K, Settle, Steven L, Shannon, Kristen E, Steininger, Christina N, Westlin, Marisa M, Westlin, William F
Published in Bioorganic & medicinal chemistry letters (01.06.2006)

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Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha(v)beta3 integrin receptor antagonists with improved oral pharmacokinetic properties

Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha(v)beta3 integrin receptor antagonists with improved oral pharmacokinetic properties

by Wendt, John A, Wu, Hongwei, Stenmark, Heather G, Boys, Mark L, Downs, Victoria L, Penning, Thomas D, Chen, Barbara B, Wang, Yaping, Duffin, Tiffany, Finn, Mary Beth, Keene, Jeffery L, Engleman, V Wayne, Freeman, Sandra K, Hanneke, Melanie L, Shannon, Kristen E, Nickols, Maureen A, Steininger, Christina N, Westlin, Marissa, Klover, Jon A, Westlin, William, Nickols, G Allen, Russell, Mark A
Published in Bioorganic & medicinal chemistry letters (15.02.2006)

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Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha sub(v) beta sub(3) integrin receptor antagonists with improved oral pharmacokinetic properties

Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha sub(v) beta sub(3) integrin receptor antagonists with improved oral pharmacokinetic properties

by Wendt, John A, Wu, Hongwei, Stenmark, Heather G, Boys, Mark L, Downs, Victoria L, Penning, Thomas D, Chen, Barbara B, Wang, Yaping, Duffin, Tiffany, Finn, Mary Beth, Keene, Jeffery L, Engleman, VWayne, Freeman, Sandra K, Hanneke, Melanie L, Shannon, Kristen E, Nickols, Maureen A, Steininger, Christina N, Westlin, Marissa, Klover, Jon A, Westlin, William, Nickols, GAllen, Russell, Mark A
Published in Bioorganic & medicinal chemistry letters (01.02.2006)

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Journal Article

Synthesis of pyrazoles and isoxazoles as potent α vβ 3 receptor antagonists

Synthesis of pyrazoles and isoxazoles as potent α vβ 3 receptor antagonists

by Penning, Thomas D., Khilevich, Albert, Chen, Barbara B., Russell, Mark A., Boys, Mark L., Wang, Yaping, Duffin, Tiffany, Engleman, V. Wayne, Finn, Mary Beth, Freeman, Sandra K., Hanneke, Melanie L., Keene, Jeffery L., Klover, Jon A., Nickols, G. Allen, Nickols, Maureen A., Rader, Randall K., Settle, Steven L., Shannon, Kristen E., Steininger, Christina N., Westlin, Marisa M., Westlin, William F.
Published in Bioorganic & medicinal chemistry letters (2006)

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Journal Article

Synthesis of 2,5-thiazole butanoic acids as potent and selective α vβ 3 integrin receptor antagonists with improved oral pharmacokinetic properties

Synthesis of 2,5-thiazole butanoic acids as potent and selective α vβ 3 integrin receptor antagonists with improved oral pharmacokinetic properties

by Wendt, John A., Wu, Hongwei, Stenmark, Heather G., Boys, Mark L., Downs, Victoria L., Penning, Thomas D., Chen, Barbara B., Wang, Yaping, Duffin, Tiffany, Finn, Mary Beth, Keene, Jeffery L., Engleman, V. Wayne, Freeman, Sandra K., Hanneke, Melanie L., Shannon, Kristen E., Nickols, Maureen A., Steininger, Christina N., Westlin, Marissa, Klover, Jon A., Westlin, William, Nickols, G. Allen, Russell, Mark A.
Published in Bioorganic & medicinal chemistry letters (2006)

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Journal Article

Synthesis of cinnamic acids and related isosteres as potent and selective alpha v beta 3 receptor antagonists

Synthesis of cinnamic acids and related isosteres as potent and selective alpha v beta 3 receptor antagonists

by Penning, Thomas D, Russell, Mark A, Chen, Barbara B, Chen, Helen Y, Desai, Bipin N, Docter, Stephen H, Edwards, David J, Gesicki, Glen J, Liang, Chi-Dean, Malecha, James W, Yu, Stella S, Engleman, V Wayne, Freeman, Sandra K, Hanneke, Melanie L, Shannon, Kristen E, Westlin, Marisa M, Nickols, G Allen
Published in Bioorganic & medicinal chemistry letters (22.03.2004)

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Convergent, parallel synthesis of a series of beta-substituted 1,2,4-oxadiazole butanoic acids as potent and selective alpha(v)beta3 receptor antagonists

Convergent, parallel synthesis of a series of beta-substituted 1,2,4-oxadiazole butanoic acids as potent and selective alpha(v)beta3 receptor antagonists

by Boys, Mark L, Schretzman, Lori A, Chandrakumar, Nizal S, Tollefson, Michael B, Mohler, Scott B, Downs, Victoria L, Penning, Thomas D, Russell, Mark A, Wendt, John A, Chen, Barbara B, Stenmark, Heather G, Wu, Hongwei, Spangler, Dale P, Clare, Michael, Desai, Bipin N, Khanna, Ish K, Nguyen, Maria N, Duffin, Tiffany, Engleman, V Wayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, G Allen, Nickols, Maureen A, Steininger, Christina N, Westlin, Marisa, Westlin, William, Yu, Yi X, Wang, Yaping, Dalton, Christopher R, Norring, Sarah A
Published in Bioorganic & medicinal chemistry letters (15.02.2006)

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Convergent, parallel synthesis of a series of beta -substituted 1,2,4- oxadiazole butanoic acids as potent and selective alpha sub(v) beta sub(3) receptor antagonists

Convergent, parallel synthesis of a series of beta -substituted 1,2,4- oxadiazole butanoic acids as potent and selective alpha sub(v) beta sub(3) receptor antagonists

by Boys, Mark L, Schretzman, Lori A, Chandrakumar, Nizal S, Tollefson, Michael B, Mohler, Scott B, Downs, Victoria L, Penning, Thomas D, Russell, Mark A, Wendt, John A, Chen, Barbara B, Stenmark, Heather G, Wu, Hongwei, Spangler, Dale P, Clare, Michael, Desai, Bipin N, Khanna, Ish K, Nguyen, Maria N, Duffin, Tiffany, Engleman, VWayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, GAllen, Nickols, Maureen A, Steininger, Christina N, Westlin, Marisa, Westlin, William, Yu, Yi X, Wang, Yaping, Dalton, Christopher R, Norring, Sarah A
Published in Bioorganic & medicinal chemistry letters (01.02.2006)

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Journal Article

Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective α vβ 3 receptor antagonists

Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective α vβ 3 receptor antagonists

by Boys, Mark L., Schretzman, Lori A., Chandrakumar, Nizal S., Tollefson, Michael B., Mohler, Scott B., Downs, Victoria L., Penning, Thomas D., Russell, Mark A., Wendt, John A., Chen, Barbara B., Stenmark, Heather G., Wu, Hongwei, Spangler, Dale P., Clare, Michael, Desai, Bipin N., Khanna, Ish K., Nguyen, Maria N., Duffin, Tiffany, Engleman, V. Wayne, Finn, Mary Beth, Freeman, Sandra K., Hanneke, Melanie L., Keene, Jeffery L., Klover, Jon A., Nickols, G. Allen, Nickols, Maureen A., Steininger, Christina N., Westlin, Marisa, Westlin, William, Yu, Yi X., Wang, Yaping, Dalton, Christopher R., Norring, Sarah A.
Published in Bioorganic & medicinal chemistry letters (2006)

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