Structural rearrangements of a polyketide synthase module during its catalytic cycle
Whicher, Jonathan R, Dutta, Somnath, Hansen, Douglas A, Hale, Wendi A, Chemler, Joseph A, Dosey, Annie M, Narayan, Alison R H, Håkansson, Kristina, Sherman, David H, Smith, Janet L, Skiniotis, Georgios
Published in Nature (London) (26.06.2014)
Published in Nature (London) (26.06.2014)
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Journal Article
Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and CH Functionalization
Lowell, Andrew N, DeMars, Matthew D, Slocum, Samuel T, Yu, Fengan, Anand, Krithika, Chemler, Joseph A, Korakavi, Nisha, Priessnitz, Jennifer K, Park, Sung Ryeol, Koch, Aaron A, Schultz, Pamela J, Sherman, David H
Published in Journal of the American Chemical Society (14.06.2017)
Published in Journal of the American Chemical Society (14.06.2017)
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Journal Article
Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering
Koryakina, Irina, Kasey, Christian, McArthur, John B, Lowell, Andrew N, Chemler, Joseph A, Li, Shasha, Hansen, Douglas A, Sherman, David H, Williams, Gavin J
Published in ACS chemical biology (20.01.2017)
Published in ACS chemical biology (20.01.2017)
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Journal Article
Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody–Drug Conjugates
Ratnayake, Anokha S, Chang, Li-ping, Tumey, L. Nathan, Loganzo, Frank, Chemler, Joseph A, Wagenaar, Melissa, Musto, Sylvia, Li, Fengping, Janso, Jeffrey E, Ballard, T. Eric, Rago, Brian, Steele, Greg L, Ding, WeiDong, Feng, Xidong, Hosselet, Christine, Buklan, Vlad, Lucas, Judy, Koehn, Frank E, O’Donnell, Christopher J, Graziani, Edmund I
Published in Bioconjugate chemistry (16.01.2019)
Published in Bioconjugate chemistry (16.01.2019)
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Journal Article
Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae
Chemler, Joseph A, Yan, Yajun, Koffas, Mattheos A G
Published in Microbial cell factories (23.05.2006)
Published in Microbial cell factories (23.05.2006)
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Journal Article
Structure of a modular polyketide synthase
Dutta, Somnath, Whicher, Jonathan R, Hansen, Douglas A, Hale, Wendi A, Chemler, Joseph A, Congdon, Grady R, Narayan, Alison R H, Håkansson, Kristina, Sherman, David H, Smith, Janet L, Skiniotis, Georgios
Published in Nature (London) (26.06.2014)
Published in Nature (London) (26.06.2014)
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Journal Article
Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination
Chemler, Joseph A, Tripathi, Ashootosh, Hansen, Douglas A, O’Neil-Johnson, Mark, Williams, Russell B, Starks, Courtney, Park, Sung Ryeol, Sherman, David H
Published in Journal of the American Chemical Society (26.08.2015)
Published in Journal of the American Chemical Society (26.08.2015)
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Journal Article
Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases
Koch, Aaron A., Schmidt, Jennifer J., Lowell, Andrew N., Hansen, Douglas A., Coburn, Katherine M., Chemler, Joseph A., Sherman, David H.
Published in Angewandte Chemie International Edition (03.08.2020)
Published in Angewandte Chemie International Edition (03.08.2020)
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Journal Article
Biochemical and Structural Characterization of Germicidin Synthase: Analysis of a Type III Polyketide Synthase That Employs Acyl-ACP as a Starter Unit Donor
Chemler, Joseph A, Buchholz, Tonia J, Geders, Todd W, Akey, David L, Rath, Christopher M, Chlipala, George E, Smith, Janet L, Sherman, David H
Published in Journal of the American Chemical Society (02.05.2012)
Published in Journal of the American Chemical Society (02.05.2012)
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Journal Article
A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S] 2+ cluster
McDonnell, Kevin J, Chemler, Joseph A, Bartels, Phillip L, O'Brien, Elizabeth, Marvin, Monica L, Ortega, Janice, Stern, Ralph H, Raskin, Leon, Li, Guo-Min, Sherman, David H, Barton, Jacqueline K, Gruber, Stephen B
Published in Nature chemistry (01.08.2018)
Published in Nature chemistry (01.08.2018)
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Journal Article
Combinatorial Mutasynthesis of Flavonoid Analogues from Acrylic Acids in Microorganisms
Chemler, Joseph A, Yan, Yajun, Leonard, Effendi, Koffas, Mattheos A. G
Published in Organic letters (10.05.2007)
Published in Organic letters (10.05.2007)
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Journal Article
Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases
Koch, Aaron A., Schmidt, Jennifer J., Lowell, Andrew N., Hansen, Douglas A., Coburn, Katherine M., Chemler, Joseph A., Sherman, David H.
Published in Angewandte Chemie (03.08.2020)
Published in Angewandte Chemie (03.08.2020)
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Journal Article
Acyl-CoA Subunit Selectivity in the Pikromycin Polyketide Synthase PikAIV: Steady-State Kinetics and Active-Site Occupancy Analysis by FTICR-MS
Bonnett, Shilah A., Rath, Christopher M., Shareef, Abdur-Rafay, Joels, Joanna R., Chemler, Joseph A., Håkansson, Kristina, Reynolds, Kevin, Sherman, David H.
Published in Chemistry & biology (23.09.2011)
Published in Chemistry & biology (23.09.2011)
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Journal Article
Characterization of a Novel Human MUTYH Variant Causing Colonic Polyposis through Disruption of the Fe-S Cluster
McDonnell, Kevin, Chemler, Joseph A., Marvin, Monica L., Stern, Ralph H., Raskin, Leon, Sherman, David H., Gruber, Stephen B.
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article
Acyl-CoA subunit selectivity in the terminal pikromycin polyketide synthase module: steady-state kinetics and active-site occupancy analysis by FTICR-MS
Bonnett, Shilah A., Rath, Christopher M., Shareef, Abdur-Rafay, Joels, Joanna R., Chemler, Joseph A., Håkansson, Kristina, Reynolds, Kevin, Sherman, David H.
Published in Chemistry & biology (23.09.2011)
Published in Chemistry & biology (23.09.2011)
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Journal Article