Predictive models for estimating cytotoxicity on the basis of chemical structures
Sun, Hongmao, Wang, Yuhong, Cheff, Dorian M., Hall, Matthew D., Shen, Min
Published in Bioorganic & medicinal chemistry (15.05.2020)
Published in Bioorganic & medicinal chemistry (15.05.2020)
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Journal Article
The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1
Cheff, Dorian M., Huang, Chuying, Scholzen, Karoline C., Gencheva, Radosveta, Ronzetti, Michael H., Cheng, Qing, Hall, Matthew D., Arnér, Elias S.J.
Published in Redox biology (01.06.2023)
Published in Redox biology (01.06.2023)
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Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
Iniguez, Amanda Balboni, Alexe, Gabriela, Wang, Emily Jue, Roti, Giovanni, Patel, Sarvagna, Chen, Liying, Kitara, Samuel, Conway, Amy, Robichaud, Amanda L., Stolte, Björn, Bandopadhayay, Pratiti, Goodale, Amy, Pantel, Sasha, Lee, Yenarae, Cheff, Dorian M., Hall, Matthew D., Guha, Rajarshi, Davis, Mindy I., Menard, Marie, Nasholm, Nicole, Weiss, William A., Qi, Jun, Beroukhim, Rameen, Piccioni, Federica, Johannessen, Cory, Stegmaier, Kimberly
Published in Cancer cell (10.12.2018)
Published in Cancer cell (10.12.2018)
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High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2
Coussens, Nathan P., Kales, Stephen C., Henderson, Mark J., Lee, Olivia W., Horiuchi, Kurumi Y., Wang, Yuren, Chen, Qing, Kuznetsova, Ekaterina, Wu, Jianghong, Chakka, Sirisha, Cheff, Dorian M., Cheng, Ken Chih-Chien, Shinn, Paul, Brimacombe, Kyle R., Shen, Min, Simeonov, Anton, Lal-Nag, Madhu, Ma, Haiching, Jadhav, Ajit, Hall, Matthew D.
Published in The Journal of biological chemistry (31.08.2018)
Published in The Journal of biological chemistry (31.08.2018)
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Journal Article
Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4
Cheff, Dorian M., Cheng, Qing, Guo, Hui, Travers, Jameson, Klumpp-Thomas, Carleen, Shen, Min, Arnér, Elias S.J., Hall, Matthew D.
Published in Redox biology (01.07.2023)
Published in Redox biology (01.07.2023)
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Journal Article
Discovery and Optimization of 2H‑1λ2‑Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer
Rohde, Jason M, Karavadhi, Surendra, Pragani, Rajan, Liu, Li, Fang, Yuhong, Zhang, Weihe, McIver, Andrew, Zheng, Hongchao, Liu, Qingyang, Davis, Mindy I, Urban, Daniel J, Lee, Tobie D, Cheff, Dorian M, Hollingshead, Melinda, Henderson, Mark J, Martinez, Natalia J, Brimacombe, Kyle R, Yasgar, Adam, Zhao, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Covey, Joseph, Moore, William J, Stott, Gordon M, Li, Zhuyin, Simeonov, Anton, Jadhav, Ajit, Frye, Stephen, Hall, Matthew D, Shen, Min, Wang, Xiaodong, Patnaik, Samarjit, Boxer, Matthew B
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities
Cheff, Dorian M, Muotri, Alysson R, Stockwell, Brent R, Schmidt, Edward E, Ran, Qitao, Kartha, Reena V, Johnson, Simon C, Mittal, Plavi, Arnér, Elias S. J, Wigby, Kristen M, Hall, Matthew D, Ramesh, Sanath Kumar
Published in Orphanet journal of rare diseases (23.10.2021)
Published in Orphanet journal of rare diseases (23.10.2021)
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Journal Article
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties
Rai, Ganesha, Urban, Daniel J, Mott, Bryan T, Hu, Xin, Yang, Shyh-Ming, Benavides, Gloria A, Johnson, Michelle S, Squadrito, Giuseppe L, Brimacombe, Kyle R, Lee, Tobie D, Cheff, Dorian M, Zhu, Hu, Henderson, Mark J, Pohida, Katherine, Sulikowski, Gary A, Dranow, David M, Kabir, Md, Shah, Pranav, Padilha, Elias, Tao, Dingyin, Fang, Yuhong, Christov, Plamen P, Kim, Kwangho, Jana, Somnath, Muttil, Pavan, Anderson, Tamara, Kunda, Nitesh K, Hathaway, Helen J, Kusewitt, Donna F, Oshima, Nobu, Cherukuri, Murali, Davies, Douglas R, Norenberg, Jeffrey P, Sklar, Larry A, Moore, William J, Dang, Chi V, Stott, Gordon M, Neckers, Leonard, Flint, Andrew J, Darley-Usmar, Victor M, Simeonov, Anton, Waterson, Alex G, Jadhav, Ajit, Hall, Matthew D, Maloney, David J
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Journal Article
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
Rohde, Jason M., Brimacombe, Kyle R., Liu, Li, Pacold, Michael E., Yasgar, Adam, Cheff, Dorian M., Lee, Tobie D., Rai, Ganesha, Baljinnyam, Bolormaa, Li, Zhuyin, Simeonov, Anton, Hall, Matthew D., Shen, Min, Sabatini, David M., Boxer, Matthew B.
Published in Bioorganic & medicinal chemistry (01.05.2018)
Published in Bioorganic & medicinal chemistry (01.05.2018)
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Journal Article
Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays
Urban, Daniel J., Martinez, Natalia J., Davis, Mindy I., Brimacombe, Kyle R., Cheff, Dorian M., Lee, Tobie D., Henderson, Mark J., Titus, Steven A., Pragani, Rajan, Rohde, Jason M., Liu, Li, Fang, Yuhong, Karavadhi, Surendra, Shah, Pranav, Lee, Olivia W., Wang, Amy, McIver, Andrew, Zheng, Hongchao, Wang, Xiaodong, Xu, Xin, Jadhav, Ajit, Simeonov, Anton, Shen, Min, Boxer, Matthew B., Hall, Matthew D.
Published in Scientific reports (06.10.2017)
Published in Scientific reports (06.10.2017)
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Journal Article
Discovery and Optimization of 2 H -1λ 2 -Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer
Rohde, Jason M, Karavadhi, Surendra, Pragani, Rajan, Liu, Li, Fang, Yuhong, Zhang, Weihe, McIver, Andrew, Zheng, Hongchao, Liu, Qingyang, Davis, Mindy I, Urban, Daniel J, Lee, Tobie D, Cheff, Dorian M, Hollingshead, Melinda, Henderson, Mark J, Martinez, Natalia J, Brimacombe, Kyle R, Yasgar, Adam, Zhao, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Covey, Joseph, Moore, William J, Stott, Gordon M, Li, Zhuyin, Simeonov, Anton, Jadhav, Ajit, Frye, Stephen, Hall, Matthew D, Shen, Min, Wang, Xiaodong, Patnaik, Samarjit, Boxer, Matthew B
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
Rai, Ganesha, Brimacombe, Kyle R, Mott, Bryan T, Urban, Daniel J, Hu, Xin, Yang, Shyh-Ming, Lee, Tobie D, Cheff, Dorian M, Kouznetsova, Jennifer, Benavides, Gloria A, Pohida, Katie, Kuenstner, Eric J, Luci, Diane K, Lukacs, Christine M, Davies, Douglas R, Dranow, David M, Zhu, Hu, Sulikowski, Gary, Moore, William J, Stott, Gordon M, Flint, Andrew J, Hall, Matthew D, Darley-Usmar, Victor M, Neckers, Leonard M, Dang, Chi V, Waterson, Alex G, Simeonov, Anton, Jadhav, Ajit, Maloney, David J
Published in Journal of medicinal chemistry (22.11.2017)
Published in Journal of medicinal chemistry (22.11.2017)
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Journal Article
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening
Lee, Olivia W., Austin, Shelley, Gamma, Madison, Cheff, Dorian M., Lee, Tobie D., Wilson, Kelli M., Johnson, Joseph, Travers, Jameson, Braisted, John C., Guha, Rajarshi, Klumpp-Thomas, Carleen, Shen, Min, Hall, Matthew D.
Published in SLAS discovery (01.01.2020)
Published in SLAS discovery (01.01.2020)
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Journal Article
Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences
Roth, Jacob S., Lee, Tobie D., Cheff, Dorian M., Gosztyla, Maya L., Asawa, Rosita R., Danchik, Carina, Michael, Sam, Simeonov, Anton, Klumpp-Thomas, Carleen, Wilson, Kelli M., Hall, Matthew D.
Published in SLAS discovery (01.06.2020)
Published in SLAS discovery (01.06.2020)
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Journal Article
Arsenic exposure and increased C-reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children
Cheff, Dorian M., Skröder, Helena, Akhtar, Evana, Cheng, Qing, Hall, Matthew D., Raqib, Rubhana, Kippler, Maria, Vahter, Marie, Arnér, Elias S.J.
Published in Redox biochemistry and chemistry (01.12.2023)
Published in Redox biochemistry and chemistry (01.12.2023)
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Journal Article
P-5 - Screening for novel inhibitors of glutathione peroxidase
Cheff, Dorian M., Cheng, Qing, Hall, Matthew D., Arnér, Elias
Published in Free radical biology & medicine (20.05.2018)
Published in Free radical biology & medicine (20.05.2018)
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Journal Article
Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity
Yang, Shyh-Ming, Martinez, Natalia J, Yasgar, Adam, Danchik, Carina, Johansson, Catrine, Wang, Yuhong, Baljinnyam, Bolormaa, Wang, Amy Q, Xu, Xin, Shah, Pranav, Cheff, Dorian, Wang, Xinran S, Roth, Jacob, Lal-Nag, Madhu, Dunford, James E, Oppermann, Udo, Vasiliou, Vasilis, Simeonov, Anton, Jadhav, Ajit, Maloney, David J
Published in Journal of medicinal chemistry (14.06.2018)
Published in Journal of medicinal chemistry (14.06.2018)
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