A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility
Sheu, Shu-Hsien, Upadhyayula, Srigokul, Dupuy, Vincent, Pang, Song, Deng, Fei, Wan, Jinxia, Walpita, Deepika, Pasolli, H Amalia, Houser, Justin, Sanchez-Martinez, Silvia, Brauchi, Sebastian E, Banala, Sambashiva, Freeman, Melanie, Xu, C Shan, Kirchhausen, Tom, Hess, Harald F, Lavis, Luke, Li, Yulong, Chaumont-Dubel, Séverine, Clapham, David E
Published in Cell (01.09.2022)
Published in Cell (01.09.2022)
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Journal Article
Spatiotemporal dynamics of 5-HT6 receptor ciliary localization during mouse brain development
Dupuy, Vincent, Prieur, Matthieu, Pizzoccaro, Anne, Margarido, Clara, Valjent, Emmanuel, Bockaert, Joël, Bouschet, Tristan, Marin, Philippe, Chaumont-Dubel, Séverine
Published in Neurobiology of disease (01.01.2023)
Published in Neurobiology of disease (01.01.2023)
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Journal Article
Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5‑HT3 and 5‑HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties
Zajdel, Paweł, Grychowska, Katarzyna, Mogilski, Szczepan, Kurczab, Rafał, Satała, Grzegorz, Bugno, Ryszard, Kos, Tomasz, Gołębiowska, Joanna, Malikowska-Racia, Natalia, Nikiforuk, Agnieszka, Chaumont-Dubel, Séverine, Bantreil, Xavier, Pawłowski, Maciej, Martinez, Jean, Subra, Gilles, Lamaty, Frédéric, Marin, Philippe, Bojarski, Andrzej J, Popik, Piotr
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Journal Article
5‐HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia
Meffre, Julie, Chaumont‐Dubel, Séverine, Mannoury la Cour, Clotilde, Loiseau, Florence, Watson, David J. G., Dekeyne, Anne, Séveno, Martial, Rivet, Jean‐Michel, Gaven, Florence, Déléris, Paul, Hervé, Denis, Fone, Kevin C. F., Bockaert, Joël, Millan, Mark J., Marin, Philippe
Published in EMBO molecular medicine (01.10.2012)
Published in EMBO molecular medicine (01.10.2012)
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Journal Article
Superiority of the Triple-Acting 5‑HT6R/5-HT3R Antagonist and MAO‑B Reversible Inhibitor PZ-1922 over 5‑HT6R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats
Grychowska, Katarzyna, López-Sánchez, Uriel, Vitalis, Mathieu, Canet, Geoffrey, Satała, Grzegorz, Olejarz-Maciej, Agnieszka, Gołębiowska, Joanna, Kurczab, Rafał, Pietruś, Wojciech, Kubacka, Monika, Moreau, Christophe, Walczak, Maria, Blicharz-Futera, Klaudia, Bento, Ophélie, Bantreil, Xavier, Subra, Gilles, Bojarski, Andrzej J., Lamaty, Frédéric, Becamel, Carine, Zussy, Charleine, Chaumont-Dubel, Séverine, Popik, Piotr, Nury, Hugues, Marin, Philippe, Givalois, Laurent, Zajdel, Paweł
Published in Journal of medicinal chemistry (09.11.2023)
Published in Journal of medicinal chemistry (09.11.2023)
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Journal Article
Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse
Berthoux, Coralie, Hamieh, Al Mahdy, Rogliardo, Angelina, Doucet, Emilie L, Coudert, Camille, Ango, Fabrice, Grychowska, Katarzyna, Chaumont‐Dubel, Séverine, Zajdel, Pawel, Maldonado, Rafael, Bockaert, Joël, Marin, Philippe, Bécamel, Carine
Published in EMBO molecular medicine (08.05.2020)
Published in EMBO molecular medicine (08.05.2020)
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Journal Article
The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism
Jacobshagen, Moritz, Niquille, Mathieu, Chaumont-Dubel, Séverine, Marin, Philippe, Dayer, Alexandre
Published in Development (Cambridge) (01.09.2014)
Published in Development (Cambridge) (01.09.2014)
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Journal Article
The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication
Fumagalli, Amos, Heuninck, Joyce, Pizzoccaro, Anne, Moutin, Enora, Koenen, Joyce, Séveno, Martial, Durroux, Thierry, Junier, Marie-Pierre, Schlecht-Louf, Géraldine, Bachelerie, Francoise, Schütz, Dagmar, Stumm, Ralf, Smit, Martine J., Guérineau, Nathalie C., Chaumont-Dubel, Séverine, Marin, Philippe
Published in Nature communications (25.09.2020)
Published in Nature communications (25.09.2020)
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Journal Article
5‑HT6 Receptor: A New Player Controlling the Development of Neural Circuits
Dayer, Alexandre G, Jacobshagen, Moritz, Chaumont-Dubel, Séverine, Marin, Philippe
Published in ACS chemical neuroscience (15.07.2015)
Published in ACS chemical neuroscience (15.07.2015)
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Journal Article
Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT6 and D3R Affinity in the 1H-Pyrrolo[3,2-c]quinoline Series
Grychowska, Katarzyna, Pietruś, Wojciech, Kulawik, Ludmiła, Bento, Ophélie, Satała, Grzegorz, Bantreil, Xavier, Lamaty, Frédéric, Bojarski, Andrzej J., Gołębiowska, Joanna, Nikiforuk, Agnieszka, Marin, Philippe, Chaumont-Dubel, Séverine, Kurczab, Rafał, Zajdel, Paweł
Published in Molecules (Basel, Switzerland) (21.01.2023)
Published in Molecules (Basel, Switzerland) (21.01.2023)
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Journal Article
Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse
Berthoux, Coralie, Hamieh, Al Mahdy, Rogliardo, Angelina, Doucet, Emilie L, Coudert, Camille, Ango, Fabrice, Grychowska, Katarzyna, Chaumont‐Dubel, Séverine, Zajdel, Pawel, Maldonado, Rafael, Bockaert, Joël, Marin, Philippe, Bécamel, Carine
Published in EMBO molecular medicine (07.09.2022)
Published in EMBO molecular medicine (07.09.2022)
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Journal Article
2‑Phenyl‑1H‑pyrrole-3-carboxamide as a New Scaffold for Developing 5‑HT6 Receptor Inverse Agonists with Cognition-Enhancing Activity
Drop, Marcin, Canale, Vittorio, Chaumont-Dubel, Séverine, Kurczab, Rafał, Satała, Grzegorz, Bantreil, Xavier, Walczak, Maria, Koczurkiewicz-Adamczyk, Paulina, Latacz, Gniewomir, Gwizdak, Anna, Krawczyk, Martyna, Gołębiowska, Joanna, Grychowska, Katarzyna, Bojarski, Andrzej J, Nikiforuk, Agnieszka, Subra, Gilles, Martinez, Jean, Pawłowski, Maciej, Popik, Piotr, Marin, Philippe, Lamaty, Frédéric, Zajdel, Paweł
Published in ACS chemical neuroscience (07.04.2021)
Published in ACS chemical neuroscience (07.04.2021)
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Journal Article
1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity
Canale, Vittorio, Trybała, Wojciech, Chaumont-Dubel, Séverine, Koczurkiewicz-Adamczyk, Paulina, Satała, Grzegorz, Bento, Ophélie, Blicharz-Futera, Klaudia, Bantreil, Xavier, Pękala, Elżbieta, Bojarski, Andrzej J., Lamaty, Frédéric, Marin, Philippe, Zajdel, Paweł
Published in Biomolecules (Basel, Switzerland) (01.01.2023)
Published in Biomolecules (Basel, Switzerland) (01.01.2023)
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Journal Article
Angiogenin induces modifications in the astrocyte secretome: Relevance to amyotrophic lateral sclerosis
Skorupa, Alexandra, Urbach, Serge, Vigy, Oana, King, Matthew A., Chaumont-Dubel, Séverine, Prehn, Jochen H.M., Marin, Philippe
Published in Journal of proteomics (08.10.2013)
Published in Journal of proteomics (08.10.2013)
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Journal Article
Classification and signaling characteristics of 5-HT receptors: toward the concept of 5-HT receptosomes
Marin, Philippe, Bécamel, Carine, Chaumont-Dubel, Séverine, Vandermoere, Franck, Bockaert, Joël, Claeysen, Sylvie
Published in Handbook of Behavioral Neuroscience (2020)
Published in Handbook of Behavioral Neuroscience (2020)
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Book Chapter
Physical interaction between neurofibromin and serotonin 5-HT₆ receptor promotes receptor constitutive activity
Nadim, Wissem Deraredj, Chaumont-Dubel, Séverine, Madouri, Fahima, Cobret, Laetitia, De Tauzia, Marie-Ludivine, Zajdel, Pawel, Bénédetti, Hélène, Marin, Philippe, Morisset-Lopez, Séverine
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2016)
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Journal Article
Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor
Labus, Josephine, Röhrs, Kian-Fritz, Ackmann, Jana, Varbanov, Hristo, Müller, Franziska E., Jia, Shaobo, Jahreis, Kathrin, Vollbrecht, Anna-Lena, Butzlaff, Malte, Schill, Yvonne, Guseva, Daria, Böhm, Katrin, Kaushik, Rahul, Bijata, Monika, Marin, Philippe, Chaumont-Dubel, Séverine, Zeug, Andre, Dityatev, Alexander, Ponimaskin, Evgeni
Published in Progress in neurobiology (01.02.2021)
Published in Progress in neurobiology (01.02.2021)
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Journal Article
mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment
Martin, Pierre-Yves, Doly, Stéphane, Hamieh, Al Mahdy, Chapuy, Eric, Canale, Vittorio, Drop, Marcin, Chaumont-Dubel, Séverine, Bantreil, Xavier, Lamaty, Frédéric, Bojarski, Andrzej J., Zajdel, Pawel, Eschalier, Alain, Marin, Philippe, Courteix, Christine
Published in Progress in neurobiology (01.10.2020)
Published in Progress in neurobiology (01.10.2020)
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Journal Article