Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
Cristofori-Armstrong, Ben, Budusan, Elena, Smith, Jennifer J., Reynaud, Steve, Voll, Kerstin, Chassagnon, Irène R., Durek, Thomas, Rash, Lachlan D.
Published in Cellular and molecular life sciences : CMLS (01.12.2024)
Published in Cellular and molecular life sciences : CMLS (01.12.2024)
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The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: Importance of interactions at the channel subunit interface and potential for engineering selective analogues
Cristofori-Armstrong, Ben, Saez, Natalie J., Chassagnon, Irène R., King, Glenn F., Rash, Lachlan D.
Published in Biochemical pharmacology (01.05.2019)
Published in Biochemical pharmacology (01.05.2019)
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A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a
Saez, Natalie J, Mobli, Mehdi, Bieri, Michael, Chassagnon, Irène R, Malde, Alpeshkumar K, Gamsjaeger, Roland, Mark, Alan E, Gooley, Paul R, Rash, Lachlan D, King, Glenn F
Published in Molecular pharmacology (01.11.2011)
Published in Molecular pharmacology (01.11.2011)
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Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid‐sensing ion channel 1a
Saez, Natalie J, Deplazes, Evelyne, Cristofori‐Armstrong, Ben, Chassagnon, Irène R, Lin, Xiaozhen, Mobli, Mehdi, Mark, Alan E, Rash, Lachlan D, King, Glenn F
Published in British journal of pharmacology (01.10.2015)
Published in British journal of pharmacology (01.10.2015)
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Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
Chassagnon, Irène R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D., King, Glenn F.
Published in Proceedings of the National Academy of Sciences - PNAS (04.04.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (04.04.2017)
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