A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition
Tarrade, Anne, Fassier, Coralie, Courageot, Sabrina, Charvin, Delphine, Vitte, Jérémie, Peris, Leticia, Thorel, Alain, Mouisel, Etienne, Fonknechten, Nuria, Roblot, Natacha, Seilhean, Danielle, Diérich, Andrée, Hauw, Jean Jacques, Melki, Judith
Published in Human molecular genetics (15.12.2006)
Published in Human molecular genetics (15.12.2006)
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Journal Article
Dopamine D2 receptor stimulation potentiates PolyQ-Huntingtin-induced mouse striatal neuron dysfunctions via Rho/ROCK-II activation
Deyts, Carole, Galan-Rodriguez, Beatriz, Martin, Elodie, Bouveyron, Nicolas, Roze, Emmanuel, Charvin, Delphine, Caboche, Jocelyne, Bétuing, Sandrine
Published in PloS one (15.12.2009)
Published in PloS one (15.12.2009)
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Journal Article
Unraveling a Role for Dopamine in Huntington's Disease: The Dual Role of Reactive Oxygen Species and D2 Receptor Stimulation
Charvin, Delphine, Vanhoutte, Peter, Pagès, Christiane, Borrelli, Emilliana, Borelli, Emiliana, Caboche, Jocelyne
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2005)
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Journal Article
Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo
Charvin, Delphine, Roze, Emmanuel, Perrin, Valérie, Deyts, Carole, Betuing, Sandrine, Pagès, Christiane, Régulier, Etienne, Luthi-Carter, Ruth, Brouillet, Emmanuel, Déglon, Nicole, Caboche, Jocelyne
Published in Neurobiology of disease (01.01.2008)
Published in Neurobiology of disease (01.01.2008)
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Journal Article
Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs
Charvin, Delphine, Medori, Rossella, Hauser, Robert A., Rascol, Olivier
Published in Nature reviews. Drug discovery (01.11.2018)
Published in Nature reviews. Drug discovery (01.11.2018)
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Journal Article
Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs
Charvin, Delphine, Medori, Rossella, Hauser, Robert A, Rascol, Olivier
Published in Nature reviews. Drug discovery (01.11.2018)
Published in Nature reviews. Drug discovery (01.11.2018)
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Journal Article
Foliglurax, a positive allosteric modulator of the metabotrophic glutamate receptor 4, protects dopaminergic neurons in MPTP-lesioned male mice
Bourque, Mélanie, Morissette, Marc, Conquet, François, Charvin, Delphine, Di Paolo, Thérèse
Published in Brain research (15.06.2023)
Published in Brain research (15.06.2023)
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Journal Article
Erratum: Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs
Charvin, Delphine, Medori, Rossella, Hauser, Robert A., Rascol, Olivier
Published in Nature reviews. Drug discovery (12.10.2018)
Published in Nature reviews. Drug discovery (12.10.2018)
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Journal Article
A positive allosteric modulator of mGlu4 receptors restores striatal plasticity in an animal model of l-Dopa-induced dyskinesia
Calabrese, Valeria, Picconi, Barbara, Heck, Nicolas, Campanelli, Federica, Natale, Giuseppina, Marino, Gioia, Sciaccaluga, Miriam, Ghiglieri, Veronica, Tozzi, Alessandro, Anceaume, Estelle, Cuoc, Emeline, Caboche, Jocelyne, Conquet, François, Calabresi, Paolo, Charvin, Delphine
Published in Neuropharmacology (01.11.2022)
Published in Neuropharmacology (01.11.2022)
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Journal Article
An mGlu4‐Positive Allosteric Modulator Alleviates Parkinsonism in Primates
Charvin, Delphine, Di Paolo, Therese, Bezard, Erwan, Gregoire, Laurent, Takano, Akihiro, Duvey, Guillaume, Pioli, Elsa, Halldin, Christer, Medori, Rossella, Conquet, François
Published in Movement disorders (01.10.2018)
Published in Movement disorders (01.10.2018)
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Journal Article
Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4
Charvin, Delphine, Pomel, Vincent, Ortiz, Millan, Frauli, Mélanie, Scheffler, Sophie, Steinberg, Edith, Baron, Luc, Deshons, Laurène, Rudigier, Rachel, Thiarc, Delphine, Morice, Christophe, Manteau, Baptiste, Mayer, Stanislas, Graham, Danielle, Giethlen, Bruno, Brugger, Nadia, Hédou, Gaël, Conquet, François, Schann, Stephan
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Journal Article
ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization
Kalinichev, Mikhail, Rouillier, Mélanie, Girard, Francoise, Royer-Urios, Isabelle, Bournique, Bruno, Finn, Terry, Charvin, Delphine, Campo, Brice, Le Poul, Emmanuel, Mutel, Vincent, Poli, Sonia, Neale, Stuart A, Salt, Thomas E, Lütjens, Robert
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
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Journal Article
A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease
Le Poul, Emmanuel, Boléa, Christelle, Girard, Francoise, Poli, Sonia, Charvin, Delphine, Campo, Brice, Bortoli, Julien, Bessif, Abdhelak, Luo, Bin, Koser, Amy Jo, Hodge, Lisa M, Smith, Karen M, DiLella, Anthony G, Liverton, Nigel, Hess, Fred, Browne, Susan E, Reynolds, Ian J
Published in The Journal of pharmacology and experimental therapeutics (01.10.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2012)
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Journal Article
An m G lu4‐ P ositive A llosteric M odulator A lleviates P arkinsonism in P rimates
Charvin, Delphine, Di Paolo, Therese, Bezard, Erwan, Gregoire, Laurent, Takano, Akihiro, Duvey, Guillaume, Pioli, Elsa, Halldin, Christer, Medori, Rossella, Conquet, François
Published in Movement disorders (01.10.2018)
Published in Movement disorders (01.10.2018)
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Journal Article
Characterization of [11C]PXT012253 as a PET Radioligand for mGlu4 Allosteric Modulators in Nonhuman Primates
Takano, Akihiro, Nag, Sangram, Jia, Zhisheng, Jahan, Mahabuba, Forsberg, Anton, Arakawa, Ryosuke, Grybäck, Per, Duvey, Guillaume, Halldin, Christer, Charvin, Delphine
Published in Molecular imaging and biology (17.06.2019)
Published in Molecular imaging and biology (17.06.2019)
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Journal Article
Characterization of [ 11 C]PXT012253 as a PET Radioligand for mGlu 4 Allosteric Modulators in Nonhuman Primates
Takano, Akihiro, Nag, Sangram, Jia, Zhisheng, Jahan, Mahabuba, Forsberg, Anton, Arakawa, Ryosuke, Grybäck, Per, Duvey, Guillaume, Halldin, Christer, Charvin, Delphine
Published in Molecular imaging and biology (01.06.2019)
Published in Molecular imaging and biology (01.06.2019)
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