The Biology of CRISPR-Cas: Backward and Forward
Hille, Frank, Richter, Hagen, Wong, Shi Pey, Bratovič, Majda, Ressel, Sarah, Charpentier, Emmanuelle
Published in Cell (08.03.2018)
Published in Cell (08.03.2018)
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The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
Fonfara, Ines, Richter, Hagen, Bratovič, Majda, Le Rhun, Anaïs, Charpentier, Emmanuelle
Published in Nature (London) (28.04.2016)
Published in Nature (London) (28.04.2016)
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A Programmable Dual-RNA—Guided DNA Endonuclease in Adaptive Bacterial Immunity
Jinek, Martin, Chylinski, Krzysztof, Fonfara, Ines, Hauer, Michael, Doudna, Jennifer A., Charpentier, Emmanuelle
Published in Science (American Association for the Advancement of Science) (17.08.2012)
Published in Science (American Association for the Advancement of Science) (17.08.2012)
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Refined sgRNA efficacy prediction improves large- and small-scale CRISPR-Cas9 applications
Labuhn, Maurice, Adams, Felix F, Ng, Michelle, Knoess, Sabine, Schambach, Axel, Charpentier, Emmanuelle M, Schwarzer, Adrian, Mateo, Juan L, Klusmann, Jan-Henning, Heckl, Dirk
Published in Nucleic acids research (16.02.2018)
Published in Nucleic acids research (16.02.2018)
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Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants
Makarova, Kira S, Wolf, Yuri I, Iranzo, Jaime, Shmakov, Sergey A, Alkhnbashi, Omer S, Brouns, Stan J J, Charpentier, Emmanuelle, Cheng, David, Haft, Daniel H, Horvath, Philippe, Moineau, Sylvain, Mojica, Francisco J M, Scott, David, Shah, Shiraz A, Siksnys, Virginijus, Terns, Michael P, Venclovas, Česlovas, White, Malcolm F, Yakunin, Alexander F, Yan, Winston, Zhang, Feng, Garrett, Roger A, Backofen, Rolf, van der Oost, John, Barrangou, Rodolphe, Koonin, Eugene V
Published in Nature reviews. Microbiology (01.02.2020)
Published in Nature reviews. Microbiology (01.02.2020)
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Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity
Charpentier, Emmanuelle, Richter, Hagen, van der Oost, John, White, Malcolm F.
Published in FEMS microbiology reviews (01.05.2015)
Published in FEMS microbiology reviews (01.05.2015)
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Adopt a moratorium on heritable genome editing
Lander, Eric S, Baylis, Françoise, Zhang, Feng, Charpentier, Emmanuelle, Berg, Paul, Bourgain, Catherine, Friedrich, Bärbel, Joung, J Keith, Li, Jinsong, Liu, David, Naldini, Luigi, Nie, Jing-Bao, Qiu, Renzong, Schoene-Seifert, Bettina, Shao, Feng, Terry, Sharon, Wei, Wensheng, Winnacker, Ernst-Ludwig
Published in Nature (London) (01.03.2019)
Published in Nature (London) (01.03.2019)
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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
Jinek, Martin, Jiang, Fuguo, Taylor, David W., Sternberg, Samuel H., Kaya, Emine, Ma, Enbo, Anders, Carolin, Hauer, Michael, Zhou, Kaihong, Lin, Steven, Kaplan, Matias, Iavarone, Anthony T., Charpentier, Emmanuelle, Nogales, Eva, Doudna, Jennifer A.
Published in Science (American Association for the Advancement of Science) (14.03.2014)
Published in Science (American Association for the Advancement of Science) (14.03.2014)
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CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
DELTCHEVA, Elitza, CHYLINSKI, Krzysztof, SHARMA, Cynthia M, GONZALES, Karine, YANJIE CHAO, PIRZADA, Zaid A, ECKERT, Maria R, VOGEL, Jörg, CHARPENTIER, Emmanuelle
Published in Nature (London) (31.03.2011)
Published in Nature (London) (31.03.2011)
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Distinct Polysaccharide Utilization Determines Interspecies Competition between Intestinal Prevotella spp
Gálvez, Eric J.C., Iljazovic, Aida, Amend, Lena, Lesker, Till Robin, Renault, Thibaud, Thiemann, Sophie, Hao, Lianxu, Roy, Urmi, Gronow, Achim, Charpentier, Emmanuelle, Strowig, Till
Published in Cell host & microbe (09.12.2020)
Published in Cell host & microbe (09.12.2020)
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An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3'-to-5' exoRNases and RNase Y
Broglia, Laura, Lécrivain, Anne-Laure, Renault, Thibaud T, Hahnke, Karin, Ahmed-Begrich, Rina, Le Rhun, Anaïs, Charpentier, Emmanuelle
Published in Nature communications (27.03.2020)
Published in Nature communications (27.03.2020)
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CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo
Reimer, Jana, Knöß, Sabine, Labuhn, Maurice, Charpentier, Emmanuelle M, Göhring, Gudrun, Schlegelberger, Brigitte, Klusmann, Jan-Henning, Heckl, Dirk
Published in Haematologica (Roma) (01.09.2017)
Published in Haematologica (Roma) (01.09.2017)
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Journal Article
Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
Bratovič, Majda, Fonfara, Ines, Chylinski, Krzysztof, Gálvez, Eric J C, Sullivan, Timothy J, Boerno, Stefan, Timmermann, Bernd, Boettcher, Michael, Charpentier, Emmanuelle
Published in Nature chemical biology (01.05.2020)
Published in Nature chemical biology (01.05.2020)
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Journal Article
Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence
Ratner, Hannah K., Escalera-Maurer, Andrés, Le Rhun, Anaïs, Jaggavarapu, Siddharth, Wozniak, Jessie E., Crispell, Emily K., Charpentier, Emmanuelle, Weiss, David S.
Published in Molecular cell (08.08.2019)
Published in Molecular cell (08.08.2019)
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Bacterial flagella grow through an injection-diffusion mechanism
Renault, Thibaud T, Abraham, Anthony O, Bergmiller, Tobias, Paradis, Guillaume, Rainville, Simon, Charpentier, Emmanuelle, Guet, Călin C, Tu, Yuhai, Namba, Keiichi, Keener, James P, Minamino, Tohru, Erhardt, Marc
Published in eLife (06.03.2017)
Published in eLife (06.03.2017)
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A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus
Resch, Ulrike, Tsatsaronis, James Anthony, Le Rhun, Anaïs, Stübiger, Gerald, Rohde, Manfred, Kasvandik, Sergo, Holzmeister, Susanne, Tinnefeld, Philip, Wai, Sun Nyunt, Charpentier, Emmanuelle
Published in mBio (01.11.2016)
Published in mBio (01.11.2016)
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Control of membrane barrier during bacterial type-III protein secretion
Hüsing, Svenja, Halte, Manuel, van Look, Ulf, Guse, Alina, Gálvez, Eric J. C., Charpentier, Emmanuelle, Blair, David F., Erhardt, Marc, Renault, Thibaud T.
Published in Nature communications (28.06.2021)
Published in Nature communications (28.06.2021)
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Journal Article
Engineering of temperature- and light-switchable Cas9 variants
Richter, Florian, Fonfara, Ines, Bouazza, Boris, Schumacher, Charlotte Helene, Bratovič, Majda, Charpentier, Emmanuelle, Möglich, Andreas
Published in Nucleic acids research (01.08.2013)
Published in Nucleic acids research (01.08.2013)
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