Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
Sykes, David A., Moore, Holly, Stott, Lisa, Holliday, Nicholas, Javitch, Jonathan A., Lane, J. Robert, Charlton, Steven J.
Published in Nature communications (02.10.2017)
Published in Nature communications (02.10.2017)
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The role of kinetic context in apparent biased agonism at GPCRs
Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan A., Christopoulos, Arthur, Lane, J. Robert
Published in Nature communications (24.02.2016)
Published in Nature communications (24.02.2016)
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Journal Article
Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D 2 receptors
Sykes, David A, Moore, Holly, Stott, Lisa, Holliday, Nicholas, Javitch, Jonathan A, Lane, J Robert, Charlton, Steven J
Published in Nature communications (02.10.2017)
Published in Nature communications (02.10.2017)
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Journal Article
Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes
Gherbi, Karolina, Briddon, Stephen J., Charlton, Steven J.
Published in Scientific reports (22.02.2018)
Published in Scientific reports (22.02.2018)
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Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2
Casella, Bianca Maria, Farmer, James P., Nesheva, Desislava N., Williams, Huw E. L., Charlton, Steven J., Holliday, Nicholas D., Laughton, Charles A., Mistry, Shailesh N.
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
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Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor
Yen, Hsin-Yung, Liko, Idlir, Song, Wanling, Kapoor, Parth, Almeida, Fernando, Toporowska, Joanna, Gherbi, Karolina, Hopper, Jonathan T. S., Charlton, Steven J., Politis, Argyris, Sansom, Mark S. P., Jazayeri, Ali, Robinson, Carol V.
Published in Nature chemistry (01.12.2022)
Published in Nature chemistry (01.12.2022)
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μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization
McPherson, Jamie, Rivero, Guadalupe, Baptist, Myma, Llorente, Javier, Al-Sabah, Suleiman, Krasel, Cornelius, Dewey, William L, Bailey, Chris P, Rosethorne, Elizabeth M, Charlton, Steven J, Henderson, Graeme, Kelly, Eamonn
Published in Molecular pharmacology (01.10.2010)
Published in Molecular pharmacology (01.10.2010)
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The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium
Sykes, David A, Dowling, Mark R, Leighton-Davies, Juliet, Kent, Toby C, Fawcett, Lindsay, Renard, Emilie, Trifilieff, Alexandre, Charlton, Steven J
Published in The Journal of pharmacology and experimental therapeutics (01.11.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2012)
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Observed drug-receptor association rates are governed by membrane affinity: the importance of establishing "micro-pharmacokinetic/pharmacodynamic relationships" at the β2-adrenoceptor
Sykes, David A, Parry, Cheryl, Reilly, John, Wright, Penny, Fairhurst, Robin A, Charlton, Steven J
Published in Molecular pharmacology (01.04.2014)
Published in Molecular pharmacology (01.04.2014)
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