Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation
Keele, Gregory R, Quach, Bryan C, Israel, Jennifer W, Chappell, Grace A, Lewis, Lauren, Safi, Alexias, Simon, Jeremy M, Cotney, Paul, Crawford, Gregory E, Valdar, William, Rusyn, Ivan, Furey, Terrence S
Published in PLoS genetics (21.01.2020)
Published in PLoS genetics (21.01.2020)
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Journal Article
In vitro screening for population variability in toxicity of pesticide-containing mixtures
Abdo, Nour, Wetmore, Barbara A., Chappell, Grace A., Shea, Damian, Wright, Fred A., Rusyn, Ivan
Published in Environment international (01.12.2015)
Published in Environment international (01.12.2015)
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Journal Article
Review of transcriptomic responses to hexavalent chromium exposure in lung cells supports a role of epigenetic mediators in carcinogenesis
Rager, Julia E., Suh, Mina, Chappell, Grace A., Thompson, Chad M., Proctor, Deborah M.
Published in Toxicology letters (01.05.2019)
Published in Toxicology letters (01.05.2019)
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Journal Article
Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks
Chappell, Grace A, Thompson, Chad M, Wolf, Jeffrey C, Cullen, John M, Klaunig, James E, Haws, Laurie C
Published in Toxicologic pathology (01.04.2020)
Published in Toxicologic pathology (01.04.2020)
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Journal Article
Overall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence
Lea, Isabel A., Chappell, Grace A., Wikoff, Daniele S.
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.08.2021)
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.08.2021)
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Journal Article
Enabling novel paradigms: a biological questions-based approach to human chemical hazard and drug safety assessment
Berridge, Brian R, Bucher, John R, Sistare, Frank, Stevens, James L, Chappell, Grace A, Clemons, Meredith, Snow, Samantha, Wignall, Jessica, Shipkowski, Kelly A
Published in Toxicological sciences (28.02.2024)
Published in Toxicological sciences (28.02.2024)
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Journal Article
Systematic evaluation of mechanistic data in assessing in utero exposures to trichloroethylene and development of congenital heart defects
Urban, Jonathan D., Wikoff, Daniele S., Chappell, Grace A., Harris, Craig, Haws, Laurie C.
Published in Toxicology (Amsterdam) (30.04.2020)
Published in Toxicology (Amsterdam) (30.04.2020)
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Journal Article
A Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens
Wikoff, Daniele S, Rager, Julia E, Chappell, Grace A, Fitch, Seneca, Haws, Laurie, Borghoff, Susan J
Published in Toxicological sciences (01.02.2019)
Published in Toxicological sciences (01.02.2019)
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Journal Article
Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort
Rager, Julia E, Auerbach, Scott S, Chappell, Grace A, Martin, Elizabeth, Thompson, Chad M, Fry, Rebecca C
Published in Chemical research in toxicology (16.10.2017)
Published in Chemical research in toxicology (16.10.2017)
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Journal Article
Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame
Borghoff, Susan J., Cohen, Sarah S., Jiang, Xiaohui, Lea, Isabel A., Klaren, William D., Chappell, Grace A., Britt, Janice K., Rivera, Brianna N., Choski, Neepa Y., Wikoff, Daniele S.
Published in Food and chemical toxicology (01.02.2023)
Published in Food and chemical toxicology (01.02.2023)
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Journal Article
Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential
Jaeschke, Hartmut, Murray, F. Jay, Monnot, Andrew D., Jacobson-Kram, David, Cohen, Samuel M., Hardisty, Jerry F., Atillasoy, Evren, Hermanowski-Vosatka, Anne, Kuffner, Edwin, Wikoff, Daniele, Chappell, Grace A., Bandara, Suren B., Deore, Milind, Pitchaiyan, Suresh Kumar, Eichenbaum, Gary
Published in Regulatory toxicology and pharmacology (01.03.2021)
Published in Regulatory toxicology and pharmacology (01.03.2021)
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Journal Article
A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives
Grimm, Fabian A, Iwata, Yasuhiro, Sirenko, Oksana, Chappell, Grace A, Wright, Fred A, Reif, David M, Braisted, John, Gerhold, David L, Yeakley, Joanne M, Shepard, Peter, Seligmann, Bruce, Roy, Tim, Boogaard, Peter J, Ketelslegers, Hans B, Rohde, Arlean M, Rusyn, Ivan
Published in Green chemistry : an international journal and green chemistry resource : GC (01.01.2016)
Published in Green chemistry : an international journal and green chemistry resource : GC (01.01.2016)
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Journal Article
A mouse model of alcoholic liver fibrosis-associated acute kidney injury identifies key molecular pathways
Furuya, Shinji, Chappell, Grace A., Iwata, Yasuhiro, Uehara, Takeki, Kato, Yuki, Kono, Hiroshi, Bataller, Ramon, Rusyn, Ivan
Published in Toxicology and applied pharmacology (01.11.2016)
Published in Toxicology and applied pharmacology (01.11.2016)
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Journal Article
A systematic approach to evaluate plausible modes of actions for mouse lung tumors in mice exposed to 4-methylimidozole
Borghoff, Susan J., Fitch, Seneca E., Black, Michael B., McMullen, Patrick D., Andersen, Melvin E., Chappell, Grace A.
Published in Regulatory toxicology and pharmacology (01.08.2021)
Published in Regulatory toxicology and pharmacology (01.08.2021)
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Journal Article
Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice
Chappell, Grace A, Israel, Jennifer W, Simon, Jeremy M, Pott, Sebastian, Safi, Alexias, Eklund, Karl, Sexton, Kenneth G, Bodnar, Wanda, Lieb, Jason D, Crawford, Gregory E, Rusyn, Ivan, Furey, Terrence S
Published in Environmental health perspectives (01.10.2017)
Published in Environmental health perspectives (01.10.2017)
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Journal Article
Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse
Lewis, Lauren, Borowa-Mazgaj, Barbara, de Conti, Aline, Chappell, Grace A, Luo, Yu-Syuan, Bodnar, Wanda, Konganti, Kranti, Wright, Fred A, Threadgill, David W, Chiu, Weihsueh A, Pogribny, Igor P, Rusyn, Ivan
Published in Chemical research in toxicology (20.05.2019)
Published in Chemical research in toxicology (20.05.2019)
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Journal Article
Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway
Chappell, Grace A., Rager, Julia E., Wolf, Jeffrey, Babic, Milos, LeBlanc, Kyle J., Ring, Caroline L., Harris, Mark A., Thompson, Chad M.
Published in Toxicologic pathology (01.10.2019)
Published in Toxicologic pathology (01.10.2019)
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Journal Article