Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle
Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P
Published in Nucleic acids research (09.07.2019)
Published in Nucleic acids research (09.07.2019)
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Journal Article
Single-Stranded siRNAs Activate RNAi in Animals
Lima, Walt F., Prakash, Thazha P., Murray, Heather M., Kinberger, Garth A., Li, Wenyu, Chappell, Alfred E., Li, Cheryl S., Murray, Susan F., Gaus, Hans, Seth, Punit P., Swayze, Eric E., Crooke, Stanley T.
Published in Cell (31.08.2012)
Published in Cell (31.08.2012)
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Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates
Østergaard, Michael E, Jackson, Michaela, Low, Audrey, E. Chappell, Alfred, G. Lee, Richard, Peralta, Rachel Q, Yu, Jinghua, Kinberger, Garth A, Dan, Amy, Carty, Rick, Tanowitz, Michael, Anderson, Patrick, Kim, Tae-Won, Fradkin, Linda, Mullick, Adam E, Murray, Sue, Rigo, Frank, Prakash, Thazha P, Bennett, C Frank, Swayze, Eric E, Gaus, Hans J, Seth, Punit P
Published in Nucleic acids research (09.07.2019)
Published in Nucleic acids research (09.07.2019)
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Journal Article
Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice
Chappell, Alfred E, Gaus, Hans J, Berdeja, Andres, Gupta, Ruchi, Jo, Minji, Prakash, Thazha P, Oestergaard, Michael, Swayze, Eric E, Seth, Punit P
Published in Nucleic acids research (07.05.2020)
Published in Nucleic acids research (07.05.2020)
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Journal Article
Lipid Nanoparticles Improve Activity of Single-Stranded siRNA and Gapmer Antisense Oligonucleotides in Animals
Prakash, Thazha P, Lima, Walt F, Murray, Heather M, Elbashir, Sayda, Cantley, William, Foster, Don, Jayaraman, Muthusamy, Chappell, Alfred E, Manoharan, Muthiah, Swayze, Eric E, Crooke, Stanley T
Published in ACS chemical biology (19.07.2013)
Published in ACS chemical biology (19.07.2013)
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Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry
Prakash, Thazha P., Brad Wan, W., Low, Audrey, Yu, Jinghua, Chappell, Alfred E., Gaus, Hans, Kinberger, Garth A., Østergaard, Michael E., Migawa, Michael T., Swayze, Eric E., Seth, Punit P.
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
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Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay
Gaus, Hans J, Gupta, Ruchi, Chappell, Alfred E, Østergaard, Michael E, Swayze, Eric E, Seth, Punit P
Published in Nucleic acids research (20.02.2019)
Published in Nucleic acids research (20.02.2019)
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Journal Article
Identification of metabolically stable 5'-phosphate analogs that support single-stranded siRNA activity
Prakash, Thazha P, Lima, Walt F, Murray, Heather M, Li, Wenyu, Kinberger, Garth A, Chappell, Alfred E, Gaus, Hans, Seth, Punit P, Bhat, Balkrishen, Crooke, Stanley T, Swayze, Eric E
Published in Nucleic acids research (31.03.2015)
Published in Nucleic acids research (31.03.2015)
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Journal Article
Targeted Delivery of Antisense Oligonucleotides Through Angiotensin Type 1 Receptor
Kuo, Carol, Nikan, Mehran, Yeh, Steve T, Chappell, Alfred E, Tanowitz, Michael, Seth, Punit P, Prakash, Thazha P, Mullick, Adam E
Published in Nucleic acid therapeutics (01.08.2022)
Published in Nucleic acid therapeutics (01.08.2022)
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Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity
Prakash, Thazha P, Lima, Walt F, Murray, Heather M, Li, Wenyu, Kinberger, Garth A, Chappell, Alfred E, Gaus, Hans, Seth, Punit P, Bhat, Balkrishen, Crooke, Stanley T, Swayze, Eric E
Published in Nucleic acids research (20.06.2017)
Published in Nucleic acids research (20.06.2017)
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Journal Article
Addition of Bromine Chloride and Iodine Monochloride to Carbonyl-Conjugated, Acetylenic Ketones: Synthesis and Mechanisms
Heasley, Victor L, Buczala, Deanna M, Chappell, Alfred E, Hill, David J, Whisenand, Josh M, Shellhamer, Dale F
Published in Journal of organic chemistry (05.04.2002)
Published in Journal of organic chemistry (05.04.2002)
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Journal Article
Hydrogen peroxide inhibits Ca²⁺-dependent chloride secretion across colonic epithelial cells via distinct kinase signaling pathways and ion transport proteins
Chappell, Alfred E, Bunz, Michael, Smoll, Eric, Dong, Hui, Lytle, Christian, Barrett, Kim E, McCole, Declan F
Published in The FASEB journal (01.06.2008)
Published in The FASEB journal (01.06.2008)
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Reactions of Carbonyl-Conjugated Alkynes with N-Bromosuccinimide and N-Iodosuccinimide in DMF/H2O and Methanol/Sulfuric Acid: Syntheses of Dihalo Diketones, Dihalo Ketoesters, and Dihalo Acetals
Heasley, Victor L, Shellhamer, Dale F, Chappell, Alfred E, Cox, Jason M, Hill, David J, McGovern, Shanna L, Eden, Cyndi C, Kissel, Charles L
Published in Journal of organic chemistry (26.06.1998)
Published in Journal of organic chemistry (26.06.1998)
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Journal Article
Reactions of Carbonyl-Conjugated Alkynes with N -Bromosuccinimide and N -Iodosuccinimide in DMF/H 2 O and Methanol/Sulfuric Acid: Syntheses of Dihalo Diketones, Dihalo Ketoesters, and Dihalo Acetals
Heasley, Victor L., Shellhamer, Dale F., Chappell, Alfred E., Cox, Jason M., Hill, David J., McGovern, Shanna L., Eden, Cyndi C., Kissel, Charles L.
Published in Journal of organic chemistry (01.06.1998)
Published in Journal of organic chemistry (01.06.1998)
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