The Target of Ezetimibe Is Niemann-Pick C1-Like 1 (NPC1L1)
Garcia-Calvo, Margarita, Lisnock, JeanMarie, Bull, Herbert G., Hawes, Brian E., Burnett, Duane A., Braun, Matthew P., Crona, James H., Davis, Harry R., Dean, Dennis C., Detmers, Patricia A., Graziano, Michael P., Hughes, Meredith, MacIntyre, D. Euan, Ogawa, Anthony, O'Neill, Kim A., Sai Prasad N. Iyer, Shevell, Diane E., Smith, Marsha M., Tang, Yui S., Makarewicz, Amanda M., Ujjainwalla, Feroze, Altmann, Scott W., Chapman, Kevin T., Thornberry, Nancy A., Goldstein, Joseph L.
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.2005)
Get full text
Journal Article
A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects
QURESHI, Sajjad A, CANDELORE, Mari Rios, GUOQIANG JIANG, BRADY, Ed, SAPERSTEIN, Richard, DUFFY, Joseph L, TATA, James R, CHAPMAN, Kevin T, MOLLER, David E, ZHANG, Bei B, DAN XIE, XIAODONG YANG, TOTA, Laurie M, DING, Victor D.-H, ZHIHUA LI, BANSAL, Alka, MILLER, Corin, COHEN, Sheila M
Published in Diabetes (New York, N.Y.) (01.12.2004)
Published in Diabetes (New York, N.Y.) (01.12.2004)
Get full text
Journal Article
Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor
Duffy, Joseph L., Kirk, Brian A., Konteatis, Zenon, Campbell, Elizabeth L., Liang, Rui, Brady, Edward J., Candelore, Mari Rios, Ding, Victor D.H., Jiang, Guoqiang, Liu, Frank, Qureshi, Sajjad A., Saperstein, Richard, Szalkowski, Deborah, Tong, Sharon, Tota, Lauri M., Xie, Dan, Yang, Xiaodong, Zafian, Peter, Zheng, Song, Chapman, Kevin T., Zhang, Bei B., Tata, James R.
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Get full text
Journal Article
Hit-to-Lead Optimization and Discovery of 5‑((5-([1,1′-Biphenyl]-4-yl)-6-chloro‑1H‑benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase
Lan, Ping, Romero, F. Anthony, Wodka, Dariusz, Kassick, Andrew J, Dang, Qun, Gibson, Tony, Cashion, Daniel, Zhou, Gaochao, Chen, Yuli, Zhang, Xiaoping, Zhang, Aihua, Li, Ying, Trujillo, Maria E, Shao, Qing, Wu, Margaret, Xu, Shiyao, He, Huaibing, MacKenna, Deidre, Staunton, Jocelyn, Chapman, Kevin T, Weber, Ann, Sebhat, Iyassu K, Makara, Gergely M
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
Get full text
Journal Article
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and sar study of 4-pyrazolylpiperidine side chains
SHEN, Dong-Ming, MIN SHU, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, SCHLEIF, William A, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael D, EMINI, Emilio A, MILLS, Sander G, CHAPMAN, Kevin T, MALKOWITZ, Lorraine, SPRINGER, Martin S, GOULD, Sandra L, DEMARTINO, Julie A, SICILIANO, Salvatore J, KWEI, Gloria Y
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Get full text
Journal Article
Combinatorial synthesis of 3-(Amidoalkyl) and 3-(Aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors
Willoughby, Christopher A, Hutchins, Steven M, Rosauer, Keith G, Dhar, Madhumeeta J, Chapman, Kevin T, Chicchi, Gary G, Sadowski, Sharon, Weinberg, David H, Patel, Smita, Malkowitz, Lorraine, Di Salvo, Jerry, Pacholok, Stephen G, Cheng, Kang
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Get full text
Journal Article
Design and Synthesis of Prolylcarboxypeptidase (PrCP) Inhibitors To Validate PrCP As A Potential Target for Obesity
Zhou, Changyou, Garcia-Calvo, Margareta, Pinto, Shirly, Lombardo, Matthew, Feng, Zhe, Bender, Kate, Pryor, KellyAnn D, Bhatt, Urmi R, Chabin, Renee M, Geissler, Wayne M, Shen, Zhu, Tong, Xinchun, Zhang, Zhoupeng, Wong, Kenny K, Roy, Ranabir Sinha, Chapman, Kevin T, Yang, Lihu, Xiong, Yusheng
Published in Journal of medicinal chemistry (14.10.2010)
Published in Journal of medicinal chemistry (14.10.2010)
Get full text
Journal Article
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core
Shen, Dong-Ming, Brady, Edward J., Candelore, Mari R., Dallas-Yang, Qing, Ding, Victor D.-H., Feeney, William P., Jiang, Guoquiang, McCann, Margaret E., Mock, Steve, Qureshi, Sajjad A., Saperstein, Richard, Shen, Xiaolan, Tong, Xinchun, Tota, Laurie M., Wright, Michael J., Yang, Xiaodong, Zheng, Song, Chapman, Kevin T., Zhang, Bei B., Tata, James R., Parmee, Emma R.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Get full text
Journal Article
Application of Affinity Selection/Mass Spectrometry to Determine the Structural Isomer of Parnafungins Responsible for Binding Polyadenosine Polymerase
Adam, Gregory C, Parish, Craig A, Wisniewski, Douglas, Meng, Juncai, Liu, Min, Calati, Kathleen, Stein, Benjamin D, Athanasopoulos, John, Liberator, Paul, Roemer, Terry, Harris, Guy, Chapman, Kevin T
Published in Journal of the American Chemical Society (10.12.2008)
Published in Journal of the American Chemical Society (10.12.2008)
Get full text
Journal Article
Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry
Rohrer, Susan P., Birzin, Elizabeth T., Mosley, Ralph T., Berk, Scott C., Hutchins, Steven M., Shen, Dong-Ming, Xiong, Yusheng, Hayes, Edward C., Parmar, Rupa M., Foor, Forrest, Mitra, Sudha W., Degrado, Sylvia J., Shu, Min, Klopp, John M., Cai, Sheng-Jian, Blake, Allan, Wanda W. S. Chan, Pasternak, Alex, Yang, Lihu, Patchett, Arthur A., Smith, Roy G., Chapman, Kevin T., Schaeffer, James M.
Published in Science (American Association for the Advancement of Science) (23.10.1998)
Published in Science (American Association for the Advancement of Science) (23.10.1998)
Get full text
Journal Article
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities
Tang, Haifeng, Yan, Yan, Feng, Zhe, de Jesus, Reynalda K., Yang, Lihu, Levorse, Dorothy A., Owens, Karen A., Akiyama, Taro E., Bergeron, Raynald, Castriota, Gino A., Doebber, Thomas W., Ellsworth, Kenneth P., Lassman, Michael E., Li, Cai, Wu, Margaret S., Zhang, Bei B., Chapman, Kevin T., Mills, Sander G., Berger, Joel P., Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Get full text
Journal Article
Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors
OGAWA, Anthony K, WILLOUGHBY, Chris A, BERGERON, Raynald, ELLSWORTH, Kenneth P, GEISSLER, Wayne M, MYERS, Robert W, JUN YAO, HARRIS, Georgianna, CHAPMAN, Kevin T
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Get full text
Journal Article
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Thornberry, Nancy A, Bull, Herbert G, Calaycay, Jimmy R, Chapman, Kevin T, Howard, Andrew D, Kostura, Matthew J, Miller, Douglas K, Molineaux, Susan M, Weidner, Jeffrey R, Aunins, John, Elliston, Keith O, Ayala, Julia M, Casano, Francesca J, Chin, Jayne, Ding, Gloria J.-F, Egger, Linda A, Gaffney, Erin P, Limjuco, Guadalupe, Palyha, Oksana C, Raju, S. M, Rolando, Anna M, Salley, J. Paul, Yamin, Ting-Ting, Lee, Terry D, Shively, John E, MacCross, Malcolm, Mumford, Richard A, Schmidt, John A, Tocci, Michael J
Published in Nature (London) (30.04.1992)
Published in Nature (London) (30.04.1992)
Get full text
Journal Article
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection
Xiong, Yusheng, Wiltsie, Judyann, Woods, Andrea, Guo, Jian, Pivnichny, James V., Tang, Wei, Bansal, Alka, Cummings, Richard T., Cunningham, Barry R., Friedlander, Arthur M., Douglas, Cameron M., Salowe, Scott P., Zaller, Dennis M., Scolnick, Edward M., Schmatz, Dennis M., Bartizal, Kenneth, Hermes, Jeffrey D., MacCoss, Malcolm, Chapman, Kevin T.
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Get full text
Journal Article
CAPTURING SPECIFIC NUCLEIC ACID MATERIALS FROM INDIVIDUAL BIOLOGICAL CELLS IN A MICRO-FLUIDIC DEVICE
WHITE MARK P, SHORT STEVEN W, MALLEO DANIELE, HOBBS ERIC D, CHAPMAN KEVIN T
Year of Publication 02.03.2021
Get full text
Year of Publication 02.03.2021
Patent
Affinity-based ranking of ligands for DPP-4 from mixtures
Adam, Gregory C., Meng, Juncai, Athanasopoulos, John, Zhang, Xiaoping, Chapman, Kevin T.
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Get full text
Journal Article
B METHODS FOR SCREENING B CELL LYMPHOCYTES
WANG XIAOHUA, RAMENANI RAVI K, WHITE MARK P, LOWE RANDALL D. JR, BRIGGS JASON C, PARK MINHA, CHAPMAN KEVIN T, CHIRRA DINAKAR HARIHARASUDHAN, HIGA ADRIENNE T, MCEWEN JASON M, SZETO KAI W
Year of Publication 02.08.2023
Get full text
Year of Publication 02.08.2023
Patent
MICROFLUIDIC CELL CULTURE
MARKS NATALIE, LOWE RANDALL D. JR, MCFARLAND ANDREW W, KARUNAKARAN AATHAVAN, GUAN XIAO, WHITE MARK P, WANG GANG F, MALLEO DANIELE, BREINLINGER KEITH J, CHAPMAN KEVIN T, BEAUMONT KRISTIN, MCEWEN JASON M, NEVILL J. TANNER
Year of Publication 02.06.2023
Get full text
Year of Publication 02.06.2023
Patent