Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006)
MacDonough, Matthew T., Strecker, Tracy E., Hamel, Ernest, Hall, John J., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Published in Bioorganic & medicinal chemistry (01.11.2013)
Published in Bioorganic & medicinal chemistry (01.11.2013)
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Journal Article
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents
Devkota, Laxman, Lin, Chen-Ming, Strecker, Tracy E., Wang, Yifan, Tidmore, Justin K., Chen, Zhi, Guddneppanavar, Rajsekhar, Jelinek, Christopher J., Lopez, Ramona, Liu, Li, Hamel, Ernest, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Published in Bioorganic & medicinal chemistry (01.03.2016)
Published in Bioorganic & medicinal chemistry (01.03.2016)
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Journal Article
Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent antitumor activity in preclinical human tumor xenograft models
Daenen, Laura G, Shaked, Yuval, Man, Shan, Xu, Ping, Voest, Emile E, Hoffman, Robert M, Chaplin, David J, Kerbel, Robert S
Published in Molecular cancer therapeutics (01.10.2009)
Published in Molecular cancer therapeutics (01.10.2009)
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Journal Article
The development of combretastatin A4 phosphate as a vascular targeting agent
Chaplin, David J, Hill, Sally A
Published in International journal of radiation oncology, biology, physics (01.12.2002)
Published in International journal of radiation oncology, biology, physics (01.12.2002)
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Journal Article
Conference Proceeding
Pharmacological inhibition of the hypertensive response to combretastatin A-4 phosphate in rats
Ke, Qingen, Bodyak, Natalya, Rigor, Debra L, Hurst, Nicole W, Chaplin, David J, Kang, Peter M
Published in Vascular pharmacology (01.11.2009)
Published in Vascular pharmacology (01.11.2009)
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Journal Article
Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization
Niu, Haichan, Strecker, Tracy E, Gerberich, Jeni L, Campbell, James W, Saha, Debabrata, Mondal, Deboprosad, Hamel, Ernest, Chaplin, David J, Mason, Ralph P, Trawick, Mary Lynn, Pinney, Kevin G
Published in Journal of medicinal chemistry (13.06.2019)
Published in Journal of medicinal chemistry (13.06.2019)
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Journal Article
Bioreductively Activatable Prodrug Conjugates of Combretastatin A‑1 and Combretastatin A‑4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia
Winn, Blake A, Devkota, Laxman, Kuch, Bunnarack, MacDonough, Matthew T, Strecker, Tracy E, Wang, Yifan, Shi, Zhe, Gerberich, Jeni L, Mondal, Deboprosad, Ramirez, Alejandro J, Hamel, Ernest, Chaplin, David J, Davis, Peter, Mason, Ralph P, Trawick, Mary Lynn, Pinney, Kevin G
Published in Journal of natural products (Washington, D.C.) (24.04.2020)
Published in Journal of natural products (Washington, D.C.) (24.04.2020)
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Journal Article
Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling
Vincent, Loïc, Kermani, Pouneh, Young, Lauren M, Cheng, Joseph, Zhang, Fan, Shido, Koji, Lam, George, Bompais-Vincent, Heidi, Zhu, Zhenping, Hicklin, Daniel J, Bohlen, Peter, Chaplin, David J, May, Chad, Rafii, Shahin
Published in The Journal of clinical investigation (01.11.2005)
Published in The Journal of clinical investigation (01.11.2005)
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Journal Article
The first international conference on vascular targeting: meeting overview
Thorpe, Philip E, Chaplin, David J, Blakey, David C
Published in Cancer research (Chicago, Ill.) (01.03.2003)
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Published in Cancer research (Chicago, Ill.) (01.03.2003)
Journal Article
Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia
Winn, Blake A., Shi, Zhe, Carlson, Graham J., Wang, Yifan, Nguyen, Benson L., Kelly, Evan M., Ross, R. David, Hamel, Ernest, Chaplin, David J., Trawick, Mary L., Pinney, Kevin G.
Published in Bioorganic & medicinal chemistry letters (01.02.2017)
Published in Bioorganic & medicinal chemistry letters (01.02.2017)
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Journal Article
The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts
Strecker, Tracy E, Odutola, Samuel O, Lopez, Ramona, Cooper, Morgan S, Tidmore, Justin K, Charlton-Sevcik, Amanda K, Li, Li, MacDonough, Matthew T, Hadimani, Mallinath B, Ghatak, Anjan, Liu, Li, Chaplin, David J, Mason, Ralph P, Pinney, Kevin G, Trawick, Mary Lynn
Published in Cancer letters (01.12.2015)
Published in Cancer letters (01.12.2015)
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Journal Article
Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L
Parker, Erica N., Odutola, Samuel O., Wang, Yifan, Strecker, Tracy E., Mukherjee, Rajeswari, Shi, Zhe, Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
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Journal Article
Chemosensitizing AML cells by targeting bone marrow endothelial cells
Bosse, Raphael C, Wasserstrom, Briana, Meacham, Amy, Wise, Elizabeth, Drusbosky, Leylah, Walter, Glenn A, Chaplin, David J, Siemann, Dietmar W, Purich, Daniel L, Cogle, Christopher R
Published in Experimental hematology (01.05.2016)
Published in Experimental hematology (01.05.2016)
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Journal Article
Synthesis of a 2‑Aryl-3-aroyl Indole Salt (OXi8007) Resembling Combretastatin A‑4 with Application as a Vascular Disrupting Agent
Hadimani, Mallinath B, MacDonough, Matthew T, Ghatak, Anjan, Strecker, Tracy E, Lopez, Ramona, Sriram, Madhavi, Nguyen, Benson L, Hall, John J, Kessler, Raymond J, Shirali, Anupama R, Liu, Li, Garner, Charles M, Pettit, George R, Hamel, Ernest, Chaplin, David J, Mason, Ralph P, Trawick, Mary Lynn, Pinney, Kevin G
Published in Journal of natural products (Washington, D.C.) (27.09.2013)
Published in Journal of natural products (Washington, D.C.) (27.09.2013)
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Journal Article
Synthesis and biological evaluation of benzocyclooctene-based and indene-based anticancer agents that function as inhibitors of tubulin polymerization
Herdman, Christine A., Strecker, Tracy E., Tanpure, Rajendra P., Chen, Zhi, Winters, Alex, Gerberich, Jeni, Liu, Li, Hamel, Ernest, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Published in MedChemComm (01.12.2016)
Published in MedChemComm (01.12.2016)
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Journal Article
Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization
Herdman, Christine A., Devkota, Laxman, Lin, Chen-Ming, Niu, Haichan, Strecker, Tracy E., Lopez, Ramona, Liu, Li, George, Clinton S., Tanpure, Rajendra P., Hamel, Ernest, Chaplin, David J., Mason, Ralph P., Trawick, Mary Lynn, Pinney, Kevin G.
Published in Bioorganic & medicinal chemistry (15.12.2015)
Published in Bioorganic & medicinal chemistry (15.12.2015)
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