Peptidomimetic Polo‐Box‐Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor
Baxter, Merissa, Chapagai, Danda, Craig, Sandra, Hurtado, Cecilia, Varghese, Jessy, Nurmemmedov, Elmar, Wyatt, Michael D., McInnes, Campbell
Published in ChemMedChem (17.06.2020)
Published in ChemMedChem (17.06.2020)
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Journal Article
Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells
Chapagai, Danda, Ramamoorthy, Gurusankar, Varghese, Jessy, Nurmemmedov, Elmar, McInnes, Campbell, Wyatt, Michael D
Published in Journal of medicinal chemistry (22.07.2021)
Published in Journal of medicinal chemistry (22.07.2021)
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Journal Article
Structural Basis for Variations in Polo-like Kinase 1 Conformation and Intracellular Stability Induced by ATP-Competitive and Novel Noncompetitive Abbapolin Inhibitors
Chapagai, Danda, Merhej, George, McInnes, Campbell, Wyatt, Michael D.
Published in ACS chemical biology (21.07.2023)
Published in ACS chemical biology (21.07.2023)
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Journal Article
Abstract 1241: Converting high affinity peptides to non-peptidic inhibitors via REPLACE: Novel and new strategies in targeting PLK1 Polo Box Domain (PBD) for anti-cancer therapy
Chapagai, Danda, Ramamoorthy, Guru, Baxter, Merissa, Craig, Sandra, Nurmemmedov, Elmar, Campbell, McInnes, Wyatt, Michael
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE
Craig, Sandra N., Baxter, Merissa, Chapagai, Danda, Stafford, Jessy M., Nurmemmedov, Elmar, Altomare, Diego, Wyatt, Michael D., McInnes, Campbell
Published in European journal of medicinal chemistry (05.01.2022)
Published in European journal of medicinal chemistry (05.01.2022)
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Journal Article
Abstract 4712: Selective polo-like kinase 1 PBD inhibitor
Chapagai, Danda P., Baxter, Merissa, Ramamoorthy, Gurusankar, McInnes, Campbell, Wyatt, Michael
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 4993: Development of abbapolin inhibitors of the PLK1 PBD as potential therapeutics for prostate and other challenging cancers
Stafford, Jessy, Chapagai, Danda, Merhej, George, Pressley, Justin, Nageswara-Rao, Chintada, Wyatt, Michael, Mcinnes, Campbell
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 2572: A novel strategy for PLK1 kinase inhibition by allosterically targeting the Polo Box Domain
Chapagai, Danda, Baxter, Merissa, Craig, Sandra, Ramamoorthy, Guru, Stafford, Jessy, Vitali, Sikirzhytski, Nurmemmedov, Elmar, McInnes, Campbell, Wyatt, Michael D.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
ABBAPOLINS AS INHIBITORS AND DEGRADERS OF POLO-LIKE KINASES
RAMAMOORTHY, GURSANKER, WYATT, MICHAEL D, MCINNES, CAMPBELL, STAFFORD, JESSY M, CHAPAGAI, DANDA PANI
Year of Publication 26.10.2023
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Year of Publication 26.10.2023
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