Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells
Nguyen, Ong Nam Phuong, Grimm, Christian, Schneider, Lina S, Chao, Yu-Kai, Atzberger, Carina, Bartel, Karin, Watermann, Anna, Ulrich, Melanie, Mayr, Doris, Wahl-Schott, Christian, Biel, Martin, Vollmar, Angelika M
Published in Cancer research (Chicago, Ill.) (15.03.2017)
Published in Cancer research (Chicago, Ill.) (15.03.2017)
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Journal Article
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
Gerndt, Susanne, Chen, Cheng-Chang, Chao, Yu-Kai, Yuan, Yu, Burgstaller, Sandra, Scotto Rosato, Anna, Krogsaeter, Einar, Urban, Nicole, Jacob, Katharina, Nguyen, Ong Nam Phuong, Miller, Meghan T, Keller, Marco, Vollmar, Angelika M, Gudermann, Thomas, Zierler, Susanna, Schredelseker, Johann, Schaefer, Michael, Biel, Martin, Malli, Roland, Wahl-Schott, Christian, Bracher, Franz, Patel, Sandip, Grimm, Christian
Published in eLife (16.03.2020)
Published in eLife (16.03.2020)
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Journal Article
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2
Netcharoensirisuk, Ponsawan, Abrahamian, Carla, Tang, Rachel, Chen, Cheng-Chang, Rosato, Anna Scotto, Beyers, Wyatt, Chao, Yu-Kai, Filippini, Antonio, Di Pietro, Santiago, Bartel, Karin, Biel, Martin, Vollmar, Angelika M., Umehara, Kaoru, De-Eknamkul, Wanchai, Grimm, Christian
Published in Scientific reports (19.04.2021)
Published in Scientific reports (19.04.2021)
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Journal Article
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes
Chen, Cheng-Chang, Cang, Chunlei, Fenske, Stefanie, Butz, Elisabeth, Chao, Yu-Kai, Biel, Martin, Ren, Dejian, Wahl-Schott, Christian, Grimm, Christian
Published in Nature protocols (01.08.2017)
Published in Nature protocols (01.08.2017)
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Journal Article
A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease
Villella, Valeria R, Venerando, Andrea, Cozza, Giorgio, Esposito, Speranza, Ferrari, Eleonora, Monzani, Romina, Spinella, Mara C, Oikonomou, Vasilis, Renga, Giorgia, Tosco, Antonella, Rossin, Federica, Guido, Stefano, Silano, Marco, Garaci, Enrico, Chao, Yu‐Kai, Grimm, Christian, Luciani, Alessandro, Romani, Luigina, Piacentini, Mauro, Raia, Valeria, Kroemer, Guido, Maiuri, Luigi
Published in The EMBO journal (15.01.2019)
Published in The EMBO journal (15.01.2019)
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Journal Article
Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect
Böck, Julia, Krogsaeter, Einar, Passon, Marcel, Chao, Yu-Kai, Sharma, Sapna, Grallert, Harald, Peters, Annette, Grimm, Christian
Published in PLoS genetics (19.01.2021)
Published in PLoS genetics (19.01.2021)
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Journal Article
TRPML Cation Channels in Inflammation and Immunity
Spix, Barbara, Chao, Yu-Kai, Abrahamian, Carla, Chen, Cheng-Chang, Grimm, Christian
Published in Frontiers in immunology (28.02.2020)
Published in Frontiers in immunology (28.02.2020)
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Journal Article
Gut butyrate-producers confer post-infarction cardiac protection
Chen, Hung-Chih, Liu, Yen-Wen, Chang, Kuan-Cheng, Wu, Yen-Wen, Chen, Yi-Ming, Chao, Yu-Kai, You, Min-Yi, Lundy, David J., Lin, Chen-Ju, Hsieh, Marvin L., Cheng, Yu-Che, Prajnamitra, Ray P., Lin, Po-Ju, Ruan, Shu-Chian, Chen, David Hsin-Kuang, Shih, Edward S. C., Chen, Ke-Wei, Chang, Shih-Sheng, Chang, Cindy M. C., Puntney, Riley, Moy, Amy Wu, Cheng, Yuan-Yuan, Chien, Hsin-Yuan, Lee, Jia-Jung, Wu, Deng-Chyang, Hwang, Ming-Jing, Coonen, Jennifer, Hacker, Timothy A., Yen, C-L. Eric, Rey, Federico E., Kamp, Timothy J., Hsieh, Patrick C. H.
Published in Nature communications (09.11.2023)
Published in Nature communications (09.11.2023)
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Journal Article
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema
Weber, Jonas, Rajan, Suhasini, Schremmer, Christian, Chao, Yu-Kai, Krasteva-Christ, Gabriela, Kannler, Martina, Yildirim, Ali Önder, Brosien, Monika, Schredelseker, Johann, Weissmann, Norbert, Grimm, Christian, Gudermann, Thomas, Dietrich, Alexander
Published in JCI insight (15.10.2020)
Published in JCI insight (15.10.2020)
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Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice
Lin, Chen-Ju, Cheng, Yu-Che, Chen, Hung-Chih, Chao, Yu-Kai, Nicholson, Martin W, Yen, Eric C L, Kamp, Timothy J, Hsieh, Patrick C H
Published in Theranostics (2022)
Published in Theranostics (2022)
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Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway
LIN, Pi-Han, KE, Yi-Yu, SU, Chun-Ting, SHIAO, Hui-Yi, HSIEH, Hsing-Pang, CHAO, Yu-Kai, LEE, Chun-Nan, KAO, Chuan-Liang, CHAO, Yu-Sheng, CHANG, Sui-Yuan
Published in Journal of Virology (01.09.2011)
Published in Journal of Virology (01.09.2011)
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Journal Article
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth
Müller, Martin, Gerndt, Susanne, Chao, Yu-Kai, Zisis, Themistoklis, Nguyen, Ong Nam Phuong, Gerwien, Aaron, Urban, Nicole, Müller, Christoph, Gegenfurtner, Florian A., Geisslinger, Franz, Ortler, Carina, Chen, Cheng-Chang, Zahler, Stefan, Biel, Martin, Schaefer, Michael, Grimm, Christian, Bracher, Franz, Vollmar, Angelika M., Bartel, Karin
Published in Cell chemical biology (19.08.2021)
Published in Cell chemical biology (19.08.2021)
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Journal Article
Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells
Siow, Wei Xiong, Kabiri, Yaschar, Tang, Rachel, Chao, Yu-Kai, Plesch, Eva, Eberhagen, Carola, Flenkenthaler, Florian, Fröhlich, Thomas, Bracher, Franz, Grimm, Christian, Biel, Martin, Zischka, Hans, Vollmar, Angelika M, Bartel, Karin
Published in Journal of cell science (15.03.2022)
Published in Journal of cell science (15.03.2022)
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Exploring the Dispersion and Electrostatic Components in Arene–Arene Interactions between Ligands and G4 DNA to Develop G4-Ligands
Andreasson, Måns, Donzel, Maxime, Abrahamsson, Alva, Berner, Andreas, Doimo, Mara, Quiroga, Anna, Eriksson, Anna, Chao, Yu-Kai, Overman, Jeroen, Pemberton, Nils, Wanrooij, Sjoerd, Chorell, Erik
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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Journal Article
Endo-Lysosomal Cation Channels and Infectious Diseases
Chao, Yu-Kai, Chang, Sui-Yuan, Grimm, Christian
Published in Reviews of physiology, biochemistry and pharmacology (01.01.2023)
Published in Reviews of physiology, biochemistry and pharmacology (01.01.2023)
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Journal Article
TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms
Chao, Yu-Kai, Schludi, Verena, Chen, Cheng-Chang, Butz, Elisabeth, Nguyen, O. N. Phuong, Müller, Martin, Krüger, Jens, Kammerbauer, Claudia, Ben-Johny, Manu, Vollmar, Angelika M., Berking, Carola, Biel, Martin, Wahl-Schott, Christian A., Grimm, Christian
Published in Proceedings of the National Academy of Sciences - PNAS (10.10.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (10.10.2017)
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Journal Article
Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes
Chen, Xi Dawn, Chen, Zeyu, Wythes, George, Zhang, Yifan, Orr, Benno C, Sun, Gary, Chao, Yu-Kai, Navarro Torres, Andrea, Thao, Ka, Vallurupalli, Mounica, Sun, Jing, Borji, Mehdi, Tkacik, Emre, Chen, Haiqi, Bernstein, Bradley E, Chen, Fei
Published in Science (American Association for the Advancement of Science) (11.10.2024)
Published in Science (American Association for the Advancement of Science) (11.10.2024)
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Journal Article
Small Molecules for Early Endosome-Specific Patch Clamping
Chen, Cheng-Chang, Butz, Elisabeth S., Chao, Yu-Kai, Grishchuk, Yulia, Becker, Lars, Heller, Stefan, Slaugenhaupt, Susan A., Biel, Martin, Wahl-Schott, Christian, Grimm, Christian
Published in Cell chemical biology (20.07.2017)
Published in Cell chemical biology (20.07.2017)
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The gut microbiota regulates acute foreign body reaction and tissue repair after biomaterial implantation
Chen, Sheng-Lun, Lundy, David J., Ruan, Shu-Chian, Chen, Hung-Chih, Chao, Yu-Kai, Cheng, Yuan-Yuan, Prajnamitra, Ray Putra, Liao, Chun-Chieh, Lin, Chung-Yen, Lai, James J., Hsieh, Patrick C.H.
Published in Biomaterials (01.10.2022)
Published in Biomaterials (01.10.2022)
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