A new modality for immunosuppression: targeting the JAK/STAT pathway
O'Shea, John J, Borie, Dominic C, Changelian, Paul S, Pesu, Marko
Published in Nature reviews. Drug discovery (01.07.2004)
Published in Nature reviews. Drug discovery (01.07.2004)
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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
Hanke, J H, Gardner, J P, Dow, R L, Changelian, P S, Brissette, W H, Weringer, E J, Pollok, B A, Connelly, P A
Published in The Journal of biological chemistry (12.01.1996)
Published in The Journal of biological chemistry (12.01.1996)
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JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants
Borie, Dominic C., O'Shea, John J., Changelian, Paul S.
Published in Trends in molecular medicine (01.11.2004)
Published in Trends in molecular medicine (01.11.2004)
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Effects of JAK3 inhibition with CP-690,550 on immune cell populations and their functions in nonhuman primate recipients of kidney allografts
Paniagua, Ricardo, Si, Ming-Sing, Flores, Mona G, Rousvoal, Geraldine, Zhang, Sally, Aalami, Oliver, Campbell, Andrew, Changelian, Paul S, Reitz, Bruce A, Borie, Dominic C
Published in Transplantation (15.11.2005)
Published in Transplantation (15.11.2005)
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Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates
Borie, Dominic C, Changelian, Paul S, Larson, Michael J, Si, Ming-Sing, Paniagua, Ricardo, Higgins, John P, Holm, Bari, Campbell, Andrew, Lau, Macy, Zhang, Sally, Flores, Mona G, Rousvoal, Geraldine, Hawkins, Jennifer, Ball, Douglas A, Kudlacz, Elizabeth M, Brissette, William H, Elliott, Eileen A, Reitz, Bruce A, Morris, Randall E
Published in Transplantation (15.04.2005)
Published in Transplantation (15.04.2005)
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Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates
Borie, Dominic C, Larson, Michael J, Flores, Mona G, Campbell, Andrew, Rousvoal, Geraldine, Zhang, Sally, Higgins, John P, Ball, Douglas J, Kudlacz, Elizabeth M, Brissette, William H, Elliott, Eileen A, Reitz, Bruce A, Changelian, Paul S
Published in Transplantation (27.12.2005)
Published in Transplantation (27.12.2005)
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Unexpected Effects of FERM Domain Mutations on Catalytic Activity of Jak3: Structural Implication for Janus Kinases
Zhou, Yong-Jie, Chen, Min, Cusack, Nancy A., Kimmel, Lida H., Magnuson, Kelly S., Boyd, James G., Lin, Wen, Roberts, Joseph L., Lengi, Andrea, Buckley, Rebecca H., Geahlen, Robert L., Candotti, Fabio, Gadina, Massimo, Changelian, Paul S., O'Shea, John J.
Published in Molecular cell (01.11.2001)
Published in Molecular cell (01.11.2001)
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Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation
Holdorf, A D, Green, J M, Levin, S D, Denny, M F, Straus, D B, Link, V, Changelian, P S, Allen, P M, Shaw, A S
Published in The Journal of experimental medicine (02.08.1999)
Published in The Journal of experimental medicine (02.08.1999)
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The Amino Terminus of JAK3 is Necessary and Sufficient for Binding to the Common γ Chain and Confers the Ability to Transmit Interleukin 2-mediated Signals
Chen, Min, Cheng, Alan, Chen, Yi-Qing, Hymel, Anka, Hanson, Eric P., Kimmel, Lida, Minami, Yasuhiro, Taniguchi, Tadatsugu, Changelian, Paul S., O'Shea, John J.
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.1997)
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Distinct Tyrosine Phosphorylation Sites in JAK3 Kinase Domain Positively and Negatively Regulate Its Enzymatic Activity
Zhou, Yong-Jie, Hanson, Eric P., Chen, Yi-Qing, Magnuson, Kelly, Chen, Min, Swann, Patrick G., Wange, Ronald L., Changelian, Paul S., O'Shea, John J.
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.1997)
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Hierarchy of Protein Tyrosine Kinases in Interleukin-2 (IL-2) Signaling: Activation of Syk Depends on Jak3; However, Neither Syk nor Lck Is Required for IL-2-Mediated STAT Activation
Zhou, Yong-Jie, Magnuson, Kelly S., Cheng, Tammy P., Gadina, Massimo, Frucht, David M., Galon, Jerome, Candotti, Fabio, Geahlen, Robert L., Changelian, Paul S., O'Shea, John J.
Published in Molecular and Cellular Biology (01.06.2000)
Published in Molecular and Cellular Biology (01.06.2000)
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Genetic Ablation of the src Kinase p59fynT Exacerbates Pulmonary Inflammation in an Allergic Mouse Model
Kudlacz, Elizabeth M, Andresen, Catharine J, Salafia, Michelle, Whitney, Carrie A, Naclerio, Barbara, Changelian, Paul S
Published in American journal of respiratory cell and molecular biology (01.04.2001)
Published in American journal of respiratory cell and molecular biology (01.04.2001)
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Journal Article
Structure of the NGFI-A Gene and Detection of Upstream Sequences Responsible for Its Transcriptional Induction by Nerve Growth Factor
Changelian, Paul S., Feng, Ping, King, Timothy C., Milbrandt, Jeffrey
Published in Proceedings of the National Academy of Sciences - PNAS (01.01.1989)
Published in Proceedings of the National Academy of Sciences - PNAS (01.01.1989)
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In vivo augmentation of IFN-γ with a rIL-12 human/mouse chimera: Pleiotropic effects against infectious agents in mice and rats
Gladue, Ronald P., Laquerre, Ann M., Magna, Holly A., Carroll, Laurie A., O'Donnell, Michele, Changelian, Paul S., Franke, Arthur E.
Published in Cytokine (Philadelphia, Pa.) (01.05.1994)
Published in Cytokine (Philadelphia, Pa.) (01.05.1994)
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PMA induces the ligand-independent internalization of CR1 on human neutrophils
Changelian, PS, Jack, RM, Collins, LA, Fearon, DT
Published in The Journal of immunology (1950) (01.03.1985)
Published in The Journal of immunology (1950) (01.03.1985)
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Immunoprecipitation with two-dimensional pools as a hybridoma screening technique: Production and characterization of monoclonal antibodies against adenovirus 2 proteins
Cepko, Constance L., Changelian, Paul S., Sharp, Phillip A.
Published in Virology (New York, N.Y.) (30.04.1981)
Published in Virology (New York, N.Y.) (30.04.1981)
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