mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
Oh, Won Jun, Wu, Chang -chih, Kim, Sung Jin, Facchinetti, Valeria, Julien, Louis -André, Finlan, Monica, Roux, Philippe P, Su, Bing, Jacinto, Estela
Published in The EMBO journal (01.12.2010)
Published in The EMBO journal (01.12.2010)
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Journal Article
mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1
Moloughney, Joseph G., Kim, Peter K., Vega-Cotto, Nicole M., Wu, Chang-Chih, Zhang, Sisi, Adlam, Matthew, Lynch, Thomas, Chou, Po-Chien, Rabinowitz, Joshua D., Werlen, Guy, Jacinto, Estela
Published in Molecular cell (01.09.2016)
Published in Molecular cell (01.09.2016)
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Journal Article
Primary cilia control translation and the cell cycle in medulloblastoma
Youn, Yong Ha, Hou, Shirui, Wu, Chang-Chih, Kawauchi, Daisuke, Orr, Brent A, Robinson, Giles W, Finkelstein, David, Taketo, Makoto M, Gilbertson, Richard J, Roussel, Martine F, Han, Young-Goo
Published in Genes & development (01.06.2022)
Published in Genes & development (01.06.2022)
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Journal Article
Production of Lentiviral Vectors Using Suspension Cells Grown in Serum-free Media
Bauler, Matthew, Roberts, Jessica K., Wu, Chang-Chih, Fan, Baochang, Ferrara, Francesca, Yip, Bon Ham, Diao, Shiyong, Kim, Young-In, Moore, Jennifer, Zhou, Sheng, Wielgosz, Matthew M., Ryu, Byoung, Throm, Robert E.
Published in Molecular therapy. Methods & clinical development (12.06.2020)
Published in Molecular therapy. Methods & clinical development (12.06.2020)
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Journal Article
mTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8
Kim, Sung Jin, DeStefano, Michael A., Oh, Won Jun, Wu, Chang-chih, Vega-Cotto, Nicole M., Finlan, Monica, Liu, Dou, Su, Bing, Jacinto, Estela
Published in Molecular cell (28.12.2012)
Published in Molecular cell (28.12.2012)
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Journal Article
mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation
Moloughney, Joseph G., Vega-Cotto, Nicole M., Liu, Sharon, Patel, Chadni, Kim, Peter K., Wu, Chang-chih, Albaciete, Danielle, Magaway, Cedric, Chang, Austin, Rajput, Swati, Su, Xiaoyang, Werlen, Guy, Jacinto, Estela
Published in The Journal of biological chemistry (19.10.2018)
Published in The Journal of biological chemistry (19.10.2018)
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Journal Article
mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
Wu, Chang-Chih, Hou, Shirui, Orr, Brent A., Kuo, Bryan R., Youn, Yong Ha, Ong, Taren, Roth, Fanny, Eberhart, Charles G., Robinson, Giles W., Solecki, David J., Taketo, Makoto M., Gilbertson, Richard J., Roussel, Martine F., Han, Young-Goo
Published in Developmental cell (18.12.2017)
Published in Developmental cell (18.12.2017)
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Vivovec™ Surface-Engineered Lentiviral Particles Mediate In Vivo CAR T Generation with Potent and Highly Durable Activity in Non-Human Primates and Tumor-Bearing Humanized Mice
Parker, Maura, Ulrich-Lewis, Justin, Tang, Weiliang, Nicolai, Chris, Michels, Kathryn, Hernandez, Susana, Parrilla, Don, Cooper, Sara, Perez, Anai, McDonnell, Mollie, Hamilton, Greyson, Wu, Chang-Chih, Shin, Seungjin, Scharenberg, Andrew M., Larson, Ryan P., Beitz, Laurie, Ryu, Byoung Y.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Mammalian Target of Rapamycin Complex 2 Modulates alpha beta TCR Processing and Surface Expression during Thymocyte Development
Chou, Po-Chien, Oh, Won Jun, Wu, Chang-Chih, Moloughney, Joseph, Rueegg, Markus A, Hall, Michael N, Jacinto, Estela, Werlen, Guy
Published in The Journal of immunology (1950) (01.08.2014)
Published in The Journal of immunology (1950) (01.08.2014)
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Journal Article
375 In vivo generation of universal CAR T cells that mediate durable anti-tumor immunity through combinatorial targeting with bispecific small molecule adapters
Mittelsteadt, Kristen, Leung, Isabel, Lynch, Kelsey, Chu, Haiyan, Chang-Chih, Wu, Shin, Seungjin, Larson, Ryan, Scharenberg, Andrew, Ryu, Byoung, Beitz, Laurie
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Journal Article
Abstract 1150: mTORC2 enhances flux through the hexosamine biosynthetic pathway by regulation of GFAT1 expression
Jacinto, Estela, Moloughney, Joseph, Lynch, Thomas, Wu, Chang-Chih, Ibironke, Olufunmilola, Navia, Aixa, Chou, Po-Chien, Zhang, Sisi, Rabinowitz, Joshua, Werlen, Guy
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
mTOR complex 2 modulates αβT-cell receptor processing and surface expression during thymocyte development 1
Chou, Po-Chien, Oh, Won Jun, Wu, Chang-Chih, Moloughney, Joseph, Rüegg, Markus, Hall, Michael N., Jacinto, Estela, Werlen, Guy
Published in The Journal of immunology (1950) (30.06.2014)
Published in The Journal of immunology (1950) (30.06.2014)
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Abstract 21: The mTORC2 target Akt is regulated in response to glutamine metabolite levels
Jacinto, Estela, Moloughney, Joseph, Kim, Peter K., Vega-Cotto, Nicole M., Wu, Chang-Chih, Lynch, Thomas, Zhang, Sisi, Adlam, Matthew, Guntaka, Sai, Chou, Po-Chien, Rabinowitz, Joshua D., Werlen, Guy
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 2441: mTOR complex 2 modulates glycosylation of CD147 via the hexosamine biosynthetic pathway
Wu, Chang-Chih, Lynch, Thomas, Moloughney, Joseph, Navia, Aixa, Ibironke, Olufunmilola, Chou, Po-Chien, Vega-Cotto, Nicole M., Zhang, Sisi, Rabinowitz, Joshua, Werlen, Guy, Jacinto, Estela
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development
Chou, Po-Chien, Oh, Won Jun, Wu, Chang-Chih, Moloughney, Joseph, Rüegg, Markus A, Hall, Michael N, Jacinto, Estela, Werlen, Guy
Published in The Journal of immunology (1950) (01.08.2014)
Published in The Journal of immunology (1950) (01.08.2014)
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