Acyl-coenzyme A:cholesterol acyltransferases
Chang, Ta-Yuan, Li, Bo-Liang, Chang, Catherine C. Y, Urano, Yasuomi
Published in American journal of physiology: endocrinology and metabolism (01.07.2009)
Published in American journal of physiology: endocrinology and metabolism (01.07.2009)
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Journal Article
Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
Guan, Chengcheng, Niu, Yange, Chen, Si-Cong, Kang, Yunlu, Wu, Jing-Xiang, Nishi, Koji, Chang, Catherine C Y, Chang, Ta-Yuan, Luo, Tuoping, Chen, Lei
Published in Nature communications (18.05.2020)
Published in Nature communications (18.05.2020)
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Journal Article
Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity
Harned, Taylor C, Stan, Radu V, Cao, Ze, Chakrabarti, Rajarshi, Higgs, Henry N, Chang, Catherine C Y, Chang, Ta Yuan
Published in International journal of molecular sciences (01.03.2023)
Published in International journal of molecular sciences (01.03.2023)
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Journal Article
ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia
Li, Haibo, Huynh, Thao N, Duong, Michael Tran, Gow, James G, Chang, Catherine C Y, Chang, Ta Yuan
Published in International journal of molecular sciences (15.03.2023)
Published in International journal of molecular sciences (15.03.2023)
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Journal Article
Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer's Disease Mice
De La Torre, Adrianna L, Huynh, Thao N, Chang, Catherine C Y, Pooler, Darcy B, Ness, Dylan B, Lewis, Lionel D, Pannem, Sanjana, Feng, Yichen, Samkoe, Kimberley S, Hickey, William F, Chang, Ta Yuan
Published in International journal of molecular sciences (01.07.2023)
Published in International journal of molecular sciences (01.07.2023)
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Journal Article
Purification of Recombinant Acyl-Coenzyme A:Cholesterol Acyltransferase 1 (ACAT1) from H293 Cells and Binding Studies between the Enzyme and Substrates Using Difference Intrinsic Fluorescence Spectroscopy
Chang, Catherine C. Y, Miyazaki, Akira, Dong, Ruhong, Kheirollah, Alireza, Yu, Chunjiang, Geng, Yong, Higgs, Henry N, Chang, Ta-Yuan
Published in Biochemistry (Easton) (23.11.2010)
Published in Biochemistry (Easton) (23.11.2010)
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Journal Article
Binding between the Niemann-Pick C1 Protein and a Photoactivatable Cholesterol Analog Requires a Functional Sterol-Sensing Domain
Ohgami, Nobutaka, Ko, Dennis C., Thomas, Matthew, Scott, Matthew P., Catherine C. Y. Chang, Chang, Ta-Yuan, Vagelos, P. Roy
Published in Proceedings of the National Academy of Sciences - PNAS (24.08.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (24.08.2004)
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Journal Article
Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation
Wang, Yong-Jian, Bian, Yan, Luo, Jie, Lu, Ming, Xiong, Ying, Guo, Shu-Yuan, Yin, Hui-Yong, Lin, Xu, Li, Qin, Chang, Catherine C Y, Chang, Ta-Yuan, Li, Bo-Liang, Song, Bao-Liang
Published in Nature cell biology (01.07.2017)
Published in Nature cell biology (01.07.2017)
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Journal Article
Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy
Duong, Michael Tran, Nasrallah, Ilya M, Wolk, David A, Chang, Catherine C Y, Chang, Ta-Yuan
Published in Frontiers in aging neuroscience (25.03.2021)
Published in Frontiers in aging neuroscience (25.03.2021)
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Journal Article
Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex
Urano, Yasuomi, Watanabe, Hiroshi, Murphy, Stephanie R, Shibuya, Yohei, Geng, Yong, Peden, Andrew A, Chang, Catherine C.Y, Chang, Ta Yuan
Published in Proceedings of the National Academy of Sciences - PNAS (28.10.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (28.10.2008)
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Journal Article
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD
Bryleva, Elena Y, Rogers, Maximillian A, Chang, Catherine C.Y, Buen, Floyd, Harris, Brent T, Rousselet, Estelle, Seidah, Nabil G, Oddo, Salvatore, LaFerla, Frank M, Spencer, Thomas A, Hickey, William F, Chang, Ta-Yuan
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2010)
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Journal Article
The Disulfide Linkage and the Free Sulfhydryl Accessibility of Acyl-Coenzyme A:Cholesterol Acyltransferase 1 As Studied by Using mPEG5000-Maleimide
Guo, Zhan-Yun, Chang, Catherine C. Y, Lu, Xiaohui, Chen, Jiang, Li, Bo-Liang, Chang, Ta-Yuan
Published in Biochemistry (Easton) (03.05.2005)
Published in Biochemistry (Easton) (03.05.2005)
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Journal Article
Blocking cholesterol storage to treat Alzheimer's disease
Chang, Ta Yuan, Chang, Catherine C Y, Harned, Taylor C, De La Torre, Adrianna L, Lee, Junghoon, Huynh, Thao N, Gow, James G
Published in Exploration of neuroprotective therapy (30.12.2021)
Published in Exploration of neuroprotective therapy (30.12.2021)
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Journal Article
TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation
Lei, Lei, Xiong, Ying, Chen, Jia, Yang, Jin-Bo, Wang, Yi, Yang, Xin-Ying, Chang, Catherine C.Y., Song, Bao-Liang, Chang, Ta-Yuan, Li, Bo-Liang
Published in Journal of lipid research (01.06.2009)
Published in Journal of lipid research (01.06.2009)
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Journal Article
MiR-9 reduces human acyl-coenzyme A:cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation
Xu, Jiajia, Hu, Guangjing, Lu, Ming, Xiong, Ying, Li, Qin, Chang, Catherine C Y, Song, Baoliang, Chang, Tayuan, Li, Boliang
Published in Acta biochimica et biophysica Sinica (01.11.2013)
Published in Acta biochimica et biophysica Sinica (01.11.2013)
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Journal Article
RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform
Chen, Jia, Zhao, Xiao-Nan, Yang, Li, Hu, Guang-Jing, Lu, Ming, Xiong, Ying, Yang, Xin-Ying, Chang, Catherine C Y, Song, Bao-Liang, Chang, Ta-Yuan, Li, Bo-Liang
Published in Cell research (01.09.2008)
Published in Cell research (01.09.2008)
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Journal Article
The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters
Guo, Dongqing, Zhang, Xiaowei, Li, Qin, Qian, Lei, Xu, Jiajia, Lu, Ming, Hu, Xihan, Zhu, Ming, Chang, Catherine C Y, Song, Baoliang, Chang, Tayuan, Xiong, Ying, Li, Boliang
Published in Acta biochimica et biophysica Sinica (01.11.2016)
Published in Acta biochimica et biophysica Sinica (01.11.2016)
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Journal Article
Association of ACAT1-Positive Vesicles with Late Endosomes/ Lysosomes in Cholesterol-Rich Human Macrophages
Lei, XiaoFeng, Fujiwara, Yukio, Chang, Catherine CY, Chang, Ta-Yuan, Takeya, Motohiro, Sakashita, Naomi
Published in Journal of Atherosclerosis and Thrombosis (01.01.2010)
Published in Journal of Atherosclerosis and Thrombosis (01.01.2010)
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Journal Article
ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration
Zhu, Ming, Zhao, Xiaonan, Chen, Jia, Xu, Jiajia, Hu, Guangjing, Guo, Dongqing, Li, Qin, Zhang, Xiaowei, Chang, Catherine C Y, Song, Baoliang, Xiong, Ying, Chang, Tayuan, Li, Boliang
Published in Acta biochimica et biophysica Sinica (01.12.2015)
Published in Acta biochimica et biophysica Sinica (01.12.2015)
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