An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria
Altrichter, Sabine, Staubach, Petra, Pasha, Malika, Singh, Bhupinder, Chang, Alan T., Bernstein, Jonathan A., Rasmussen, Henrik S., Siebenhaar, Frank, Maurer, Marcus
Published in Journal of allergy and clinical immunology (01.05.2022)
Published in Journal of allergy and clinical immunology (01.05.2022)
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Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis
Dellon, Evan S, Peterson, Kathryn A, Murray, Joseph A, Falk, Gary W, Gonsalves, Nirmala, Chehade, Mirna, Genta, Robert M, Leung, John, Khoury, Paneez, Klion, Amy D, Hazan, Sabine, Vaezi, Michael, Bledsoe, Adam C, Durrani, Sandy R, Wang, Chao, Shaw, Camilla, Chang, Alan T, Singh, Bhupinder, Kamboj, Amol P, Rasmussen, Henrik S, Rothenberg, Marc E, Hirano, Ikuo
Published in The New England journal of medicine (22.10.2020)
Published in The New England journal of medicine (22.10.2020)
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Discovery, Function, and Therapeutic Targeting of Siglec-8
Youngblood, Bradford A, Leung, John, Falahati, Rustom, Williams, Jason, Schanin, Julia, Brock, Emily C, Singh, Bhupinder, Chang, Alan T, O'Sullivan, Jeremy A, Schleimer, Robert P, Tomasevic, Nenad, Bebbington, Christopher R, Bochner, Bruce S
Published in Cells (Basel, Switzerland) (24.12.2020)
Published in Cells (Basel, Switzerland) (24.12.2020)
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Journal Article
Eosinophil and mast cell Siglecs: From biology to drug target
O'Sullivan, Jeremy A., Chang, Alan T., Youngblood, Bradford A., Bochner, Bruce S.
Published in Journal of leukocyte biology (01.07.2020)
Published in Journal of leukocyte biology (01.07.2020)
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Siglecs in allergy and asthma
Bochner, Bruce S., O'Sullivan, Jeremy A., Chang, Alan T., Youngblood, Bradford A.
Published in Molecular aspects of medicine (01.04.2023)
Published in Molecular aspects of medicine (01.04.2023)
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Journal Article
Determination of Biopsy Yield That Optimally Detects Eosinophilic Gastritis and/or Duodenitis in a Randomized Trial of Lirentelimab
Dellon, Evan S., Gonsalves, Nirmala, Rothenberg, Marc E., Hirano, Ikuo, Chehade, Mirna, Peterson, Kathryn A., Falk, Gary W., Murray, Joseph A., Gehman, Lauren T., Chang, Alan T., Singh, Bhupinder, Rasmussen, Henrik S., Genta, Robert M.
Published in Clinical gastroenterology and hepatology (01.03.2022)
Published in Clinical gastroenterology and hepatology (01.03.2022)
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Safety and efficacy of lirentelimab in patients with refractory indolent systemic mastocytosis: a first-in-human clinical trial
Siebenhaar, Frank, Altrichter, Sabine, Bonnekoh, Hanna, Hawro, Tomasz, Hawro, Marlena, Michaelis, Edward G, Kantor, Andrea M, Chang, Alan T, Youngblood, Bradford A, Singh, Bhupinder, Rasmussen, Henrik S, Maurer, Marcus
Published in British journal of dermatology (1951) (25.10.2023)
Published in British journal of dermatology (1951) (25.10.2023)
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Lirentelimab for severe and chronic forms of allergic conjunctivitis
Anesi, Stephen D, Tauber, Joseph, Nguyen, Quan Dong, Chang, Peter, Berdy, Gregg J, Lin, Charles C, Chu, David S, Levine, H Terry, Fernandez, Andrew D, Roy, Neeta, Asbell, Penny A, Kantor, Andrea M, Chang, Alan T, Singh, Bhupinder, Youngblood, Bradford A, Jeng, Bennie H, Jhanji, Vishal, Rasmussen, Henrik S, Foster, C Stephen
Published in Journal of allergy and clinical immunology (01.09.2022)
Published in Journal of allergy and clinical immunology (01.09.2022)
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Journal Article
High Discovery Rate of Duodenal and Gastric Eosinophilia in Patients With Unexplained Moderate–Severe Abdominal Symptoms: A Prospective US Multisite Study
Talley, Nicholas J., Peterson, Kathryn A., Genta, Robert M., Chang, Alan T., Dellon, Evan S., Sandborn, William J., Lacy, Brian E., Chehade, Mirna, Hirano, Ikuo, Gonsalves, Nirmala, Lembo, Anthony, Schmitt, Colleen M., Rothenberg, Marc E., Jain, Neal, Pletneva, Maria A., Turner, Kevin O., Youngblood, Bradford A.
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2023)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2023)
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Journal Article
A Randomized, Double-Blind, Placebo-Controlled, Ascending Dose Phase 1 Study of AK002, a Novel Siglec-8 Selective Monoclonal Antibody, in Healthy Subjects
Rasmussen, Henrik S., Chang, Alan T., Tomasevic, Nenad, Bebbington, Christopher
Published in Journal of allergy and clinical immunology (01.02.2018)
Published in Journal of allergy and clinical immunology (01.02.2018)
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Journal Article
S449 Lirentelimab (AK002) Safety and Efficacy in Patients With Higher Eosinophil Thresholds: Supplementary Analysis of Phase 2/3 EoE KRYPTOS Trial
Dellon, Evan, Chehade, Mirna, Genta, Robert M., Leiman, David A., Peterson, Kathryn A., Spergel, Jonathan, Wechsler, Joshua, Bortey, Enoch, Chang, Alan T., Hirano, Ikuo
Published in The American journal of gastroenterology (01.10.2022)
Published in The American journal of gastroenterology (01.10.2022)
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Journal Article
S446 Results from KRYPTOS, a Phase 2/3 Study of Lirentelimab (AK002) in Adults and Adolescents With EoE
Dellon, Evan, Chehade, Mirna, Genta, Robert M., Leiman, David A., Peterson, Kathryn A., Spergel, Jonathan, Wechsler, Joshua, Bortey, Enoch, Chang, Alan T., Hirano, Ikuo
Published in The American journal of gastroenterology (01.10.2022)
Published in The American journal of gastroenterology (01.10.2022)
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Journal Article
Determination of Optimal Eosinophil Thresholds for Diagnosis of Eosinophilic Gastritis and Duodenitis: A Pooled Analysis of 4 Prospective Studies
Dellon, Evan S, Bortey, Enoch, Chang, Alan T, Paterson, Craig A, Turner, Kevin, Genta, Robert M
Published in Clinical and translational gastroenterology (01.01.2024)
Published in Clinical and translational gastroenterology (01.01.2024)
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484 - Phase 2 trial in progress - lirentelimab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments
Rodriguez, Cristian, Moyer, Anesa, Chang, Alan T, Bortey, Enoch, Paterson, Craig
Published in British journal of dermatology (1951) (07.02.2024)
Published in British journal of dermatology (1951) (07.02.2024)
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Journal Article
365 Phase 2 trial in progress—lirentelimab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments
Rodriguez, Cristian, Moyer, Anesa, Chang, Alan T, Bortey, Enoch, Paterson, Craig
Published in British journal of dermatology (1951) (20.06.2023)
Published in British journal of dermatology (1951) (20.06.2023)
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Journal Article
286 Phase 2 proof-of-concept trial in progress—lirentelimab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments
Rodriguez, Cristian, Moyer, Anesa, Chang, Alan T, Bortey, Enoch, Paterson, Craig
Published in British journal of dermatology (1951) (25.01.2023)
Published in British journal of dermatology (1951) (25.01.2023)
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AK002, a Novel Humanized Monoclonal Antibody to Siglec-8, Inhibits Mast Cell Activity and Depletes Eosinophils in Ex Vivo Bone Marrow Tissue from Patients with Systemic Mastocytosis
Youngblood, Bradford A, Brock, Emily C, Leung, John, Chang, Alan T, Bebbington, Christopher, Tomasevic, Nenad
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Mo1236 MAST CELL LEVEL AND CLINICAL CORRELATES IN PATIENS WITH EOSINOPHILIC GASTRITIS AND GASTROENTERITIS
Reed, Craig C., Genta, Robert M., Youngblood, Bradford, Chang, Alan T., Kamboj, Amol P., Wechsler, Joshua B., Rasmussen, Henrik S., Dellon, Evan S.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
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Journal Article
Mo1237 ESTABLISHMENT OF NORMAL TISSUE MAST CELL LEVELS IN GASTRIC AND DUODENAL BIOPSIES OF PATIENTS WTHOUT GASTROINTESTINAL DISEASE
Reed, Craig C., Genta, Robert M., Youngblood, Bradford, Chang, Alan T., Kamboj, Amol P., Wechsler, Joshua B., Rasmussen, Henrik S., Dellon, Evan S.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
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CARBON MATERIALS COMPRISING ENHANCED ELECTROCHEMICAL PROPERTIES
WILLIAM D. SCOTT, CHANG ALAN T, PAN YANGYANG, COVER LIAM, FEAVER AARON M, COSTANTINO HENRY R, OPPIE AMALIA L
Year of Publication 23.07.2014
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Year of Publication 23.07.2014
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