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Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
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Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
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Stereotactic Radiosurgery for Melanoma Brain Metastases in Patients Receiving Ipilimumab: Safety Profile and Efficacy of Combined Treatment
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Published in International journal of radiation oncology, biology, physics (01.06.2015)
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Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
Rizvi, Naiyer A., Hellmann, Matthew D., Snyder, Alexandra, Kvistborg, Pia, Makarov, Vladimir, Havel, Jonathan J., Lee, William, Yuan, Jianda, Wong, Phillip, Ho, Teresa S., Miller, Martin L., Rekhtman, Natasha, Moreira, Andre L., Ibrahim, Fawzia, Bruggeman, Cameron, Gasmi, Billel, Zappasodi, Roberta, Maeda, Yuka, Sander, Chris, Garon, Edward B., Merghoub, Taha, Wolchok, Jedd D., Schumacher, Ton N., Chan, Timothy A.
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Published in Science (American Association for the Advancement of Science) (03.04.2015)
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Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
Snyder, Alexandra, Makarov, Vladimir, Merghoub, Taha, Yuan, Jianda, Zaretsky, Jesse M, Desrichard, Alexis, Walsh, Logan A, Postow, Michael A, Wong, Phillip, Ho, Teresa S, Hollmann, Travis J, Bruggeman, Cameron, Kannan, Kasthuri, Li, Yanyun, Elipenahli, Ceyhan, Liu, Cailian, Harbison, Christopher T, Wang, Lisu, Ribas, Antoni, Wolchok, Jedd D, Chan, Timothy A
Published in The New England journal of medicine (04.12.2014)
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Next-generation sequencing: unraveling genetic mechanisms that shape cancer immunotherapy efficacy
Halima, Ahmed, Vuong, Winston, Chan, Timothy A
Published in The Journal of clinical investigation (15.06.2022)
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Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
Chiappinelli, Katherine B., Strissel, Pamela L., Desrichard, Alexis, Li, Huili, Henke, Christine, Akman, Benjamin, Hein, Alexander, Rote, Neal S., Cope, Leslie M., Snyder, Alexandra, Makarov, Vladimir, Buhu, Sadna, Slamon, Dennis J., Wolchok, Jedd D., Pardoll, Drew M., Beckmann, Matthias W., Zahnow, Cynthia A., Merghoub, Taha, Chan, Timothy A., Baylin, Stephen B., Strick, Reiner
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Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas
Desrichard, Alexis, Kuo, Fengshen, Chowell, Diego, Lee, Ken-Wing, Riaz, Nadeem, Wong, Richard J, Chan, Timothy A, Morris, Luc G T
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Published in JNCI : Journal of the National Cancer Institute (01.12.2018)
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The role of neoantigens in response to immune checkpoint blockade
Riaz, Nadeem, Morris, Luc, Havel, Jonathan J, Makarov, Vladimir, Desrichard, Alexis, Chan, Timothy A
Published in International immunology (01.08.2016)
Published in International immunology (01.08.2016)
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G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
Wang, Yuxiang, Yang, Jie, Wild, Aaron T., Wu, Wei H., Shah, Rachna, Danussi, Carla, Riggins, Gregory J., Kannan, Kasthuri, Sulman, Erik P., Chan, Timothy A., Huse, Jason T.
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Frequent Somatic TERT Promoter Mutations in Thyroid Cancer: Higher Prevalence in Advanced Forms of the Disease
Landa, Iñigo, Ganly, Ian, Chan, Timothy A, Mitsutake, Norisato, Matsuse, Michiko, Ibrahimpasic, Tihana, Ghossein, Ronald A, Fagin, James A
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Published in The journal of clinical endocrinology and metabolism (01.09.2013)
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Aging‐related cell type‐specific pathophysiologic immune responses that exacerbate disease severity in aged COVID‐19 patients
Hou, Yuan, Zhou, Yadi, Jehi, Lara, Luo, Yuan, Gack, Michaela U., Chan, Timothy A., Yu, Haiyuan, Eng, Charis, Pieper, Andrew A., Cheng, Feixiong
Published in Aging cell (01.02.2022)
Published in Aging cell (01.02.2022)
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Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers
Knudsen, Erik S, Vail, Paris, Balaji, Uthra, Ngo, Hoai, Botros, Ihab W, Makarov, Vladimir, Riaz, Nadeem, Balachandran, Vinod, Leach, Steven, Thompson, Debrah M, Chan, Timothy A, Witkiewicz, Agnieszka K
Published in Clinical cancer research (01.08.2017)
Published in Clinical cancer research (01.08.2017)
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Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes
Ganly, Ian, Makarov, Vladimir, Deraje, Shyamprasad, Dong, YiYu, Reznik, Ed, Seshan, Venkatraman, Nanjangud, Gouri, Eng, Stephanie, Bose, Promita, Kuo, Fengshen, Morris, Luc G.T., Landa, Inigo, Carrillo Albornoz, Pedro Blecua, Riaz, Nadeem, Nikiforov, Yuri E., Patel, Kepal, Umbricht, Christopher, Zeiger, Martha, Kebebew, Electron, Sherman, Eric, Ghossein, Ronald, Fagin, James A., Chan, Timothy A.
Published in Cancer cell (13.08.2018)
Published in Cancer cell (13.08.2018)
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ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
Chan, Chang S., Laddha, Saurabh V., Lewis, Peter W., Koletsky, Matthew S., Robzyk, Kenneth, Da Silva, Edaise, Torres, Paula J., Untch, Brian R., Li, Janet, Bose, Promita, Chan, Timothy A., Klimstra, David S., Allis, C. David, Tang, Laura H.
Published in Nature communications (12.10.2018)
Published in Nature communications (12.10.2018)
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