Block of NF-kB signaling accelerates MYC-driven hepatocellular carcinogenesis and modifies the tumor phenotype towards combined hepatocellular cholangiocarcinoma
He, Jiajia, Gerstenlauer, Melanie, Chan, Lap Kwan, Leithäuser, Frank, Yeh, Matthew M., Wirth, Thomas, Maier, Harald J.
Published in Cancer letters (28.08.2019)
Published in Cancer letters (28.08.2019)
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Journal Article
NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer
Tsesmelis, Miltiadis, Büttner, Ulrike F G, Gerstenlauer, Melanie, Manfras, Uta, Tsesmelis, Konstantinos, Du, Ziwei, Sperb, Nadine, Weissinger, Stephanie Ellen, Möller, Peter, Barth, Thomas F E, Maier, Harald J, Chan, Lap Kwan, Wirth, Thomas
Published in Molecular cancer (16.05.2024)
Published in Molecular cancer (16.05.2024)
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Journal Article
IKK/NF-kappaB Signaling in Pancreatic Stellate Cells Plays an Essential Role in Regulating the Immune Response During Pancreatitis
Chan, Lap Kwan, Maier, Harald J, Wirth, Thomas
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (01.07.2017)
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (01.07.2017)
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Journal Article
Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis
Chan, Lap Kwan, Tsesmelis, Miltiadis, Gerstenlauer, Melanie, Leithäuser, Frank, Kleger, Alexander, Frick, Lukas Daniel, Maier, Harald Jacob, Wirth, Thomas
Published in Communications biology (27.05.2022)
Published in Communications biology (27.05.2022)
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Journal Article
Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma
Clerbaux, Laure-Alix, Cordier, Pierre, Desboeufs, Nina, Unger, Kristian, Leary, Peter, Semere, Gabriel, Boege, Yannick, Chan, Lap Kwan, Desdouets, Chantal, Lopes, Massimo, Weber, Achim
Published in JHEP reports (01.10.2023)
Published in JHEP reports (01.10.2023)
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Journal Article
Deletion of NEMO Inhibits EMT and Reduces Metastasis in KPC Mice
Tsesmelis, Miltiadis, Tiwary, Kanishka, Steiger, Katja, Sperb, Nadine, Gerstenlauer, Melanie, Manfras, Uta, Maier, Harald, Hermann, Patrick, Chan, Lap, Wirth, Thomas
Published in Cancers (10.09.2021)
Published in Cancers (10.09.2021)
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Journal Article
Hepatocyte-specific deletiton of the anti-apoptotic Mcl-1 in mice induces polyploidization, mitotic erros and chromosomal instability
Clerbaux, Laure-Alix, Cordier, Pierre, Desboeufs, Nina, Unger, Kristian, Semere, Gabriel, Chan, Lap Kwan, Desdouets, Chantal, Lopes, Massimo, Weber, Achim
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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Journal Article
Epithelial NEMO/IKKγ limits fibrosis and promotes regeneration during pancreatitis
Chan, Lap Kwan, Gerstenlauer, Melanie, Konukiewitz, Björn, Steiger, Katja, Weichert, Wilko, Wirth, Thomas, Maier, Harald Jakob
Published in Gut (01.11.2017)
Published in Gut (01.11.2017)
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Journal Article
NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer
Tsesmelis, Miltiadis, Büttner, Ulrike F. G, Gerstenlauer, Melanie, Manfras, Uta, Tsesmelis, Konstantinos, Du, Ziwei, Sperb, Nadine, Weissinger, Stephanie Ellen, Möller, Peter, Barth, Thomas F. E, Maier, Harald J, Chan, Lap Kwan, Wirth, Thomas
Published in Molecular cancer (16.05.2024)
Published in Molecular cancer (16.05.2024)
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Journal Article
Epithelial NEMO/IKK[gamma] limits fibrosis and promotes regeneration during pancreatitis
Chan, Lap Kwan, Gerstenlauer, Melanie, Konukiewitz, Björn, Steiger, Katja, Weichert, Wilko, Wirth, Thomas, Maier, Harald Jakob
Published in Gut (01.11.2017)
Published in Gut (01.11.2017)
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Journal Article
Ablation of NEMO/ IKKgamma Exacerbates Fibrosis and Impairs Regeneration in a mouse model of pancreatitis
Chan, Lap Kwan, Wirth, Thomas, Maier, Harald
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (01.06.2015)
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (01.06.2015)
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Journal Article
MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice
Healy, Marc E., Boege, Yannick, Hodder, Michael C., Böhm, Friederike, Malehmir, Mohsen, Scherr, Anna-Lena, Jetzer, Jasna, Chan, Lap Kwan, Parrotta, Rossella, Jacobs, Kurt, Clerbaux, Laure-Alix, Kreutzer, Susanne, Campbell, Andrew, Gilchrist, Ella, Gilroy, Kathryn, Rodewald, Ann-Katrin, Honcharova-Biletska, Hanna, Schimmer, Roman, Vélez, Karelia, Büeler, Simone, Cammareri, Patrizia, Kalna, Gabriela, Wenning, Anna S., McCoy, Kathy D., Gomez de Agüero, Mercedes, Schulze-Bergkamen, Henning, Klose, Christoph S.N., Unger, Kristian, Macpherson, Andrew J., Moor, Andreas E., Köhler, Bruno, Sansom, Owen J., Heikenwälder, Mathias, Weber, Achim
Published in Gastroenterology (New York, N.Y. 1943) (01.07.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.07.2020)
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Journal Article
JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging
Müller, Katrin, Honcharova-Biletska, Hanna, Koppe, Christiane, Egger, Michèle, Chan, Lap Kwan, Schneider, Anne T, Küsgens, Lena, Böhm, Friederike, Boege, Yannick, Healy, Marc E, Schmitt, Johannes, Comtesse, Sarah, Castoldi, Mirco, Preisinger, Christian, Szydlowska, Marta, Focaccia, Enrico, Gaisa, Nadine T, Loosen, Sven H, Jörs, Simone, Tacke, Frank, Roderburg, Christoph, Keitel, Verena, Bode, Johannes G, Boor, Peter, Davis, Roger J, Longerich, Thomas, Geisler, Fabian, Heikenwalder, Mathias, Weber, Achim, Vucur, Mihael, Luedde, Tom
Published in Proceedings of the National Academy of Sciences - PNAS (23.03.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (23.03.2021)
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Journal Article
Abstract B070: Deletion of NEMO inhibits PanIN development but accelerates PanIN progression towards PDAC
Tsesmelis, Miltiadis, Gerstenlauer, Melanie, Manfras, Uta, Barth, Thomas F.E., Maier, Harald Jakob, Chan, Lap Kwan, Wirth, Thomas
Published in Cancer research (Chicago, Ill.) (15.11.2022)
Published in Cancer research (Chicago, Ill.) (15.11.2022)
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Journal Article
The IKK subunit NEMO is essential for KRAS-induced pancreatic intraepithelial neoplasia
Maier, Harald, Chan, Lap Kwan, Schips, Tobias, Wagner, Martin, Baumann, Bernd, Wirth, Thomas
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (01.06.2015)
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (01.06.2015)
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