Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
Chan, Kui K, Dorosky, Danielle, Sharma, Preeti, Abbasi, Shawn A, Dye, John M, Kranz, David M, Herbert, Andrew S, Procko, Erik
Published in Science (04.09.2020)
Published in Science (04.09.2020)
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Machine Learning Guided Design of High-Affinity ACE2 Decoys for SARS-CoV‑2 Neutralization
Chan, Matthew C., Chan, Kui. K., Procko, Erik, Shukla, Diwakar
Published in The journal of physical chemistry. B (09.03.2023)
Published in The journal of physical chemistry. B (09.03.2023)
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Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants
Zhang, Lianghui, Dutta, Soumajit, Xiong, Shiqin, Chan, Matthew, Chan, Kui K., Fan, Timothy M., Bailey, Keith L., Lindeblad, Matthew, Cooper, Laura M., Rong, Lijun, Gugliuzza, Anthony F., Shukla, Diwakar, Procko, Erik, Rehman, Jalees, Malik, Asrar B.
Published in Nature chemical biology (01.03.2022)
Published in Nature chemical biology (01.03.2022)
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An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2
Zhang, Lianghui, Narayanan, Krishna K, Cooper, Laura, Chan, Kui K, Skeeters, Savanna S, Devlin, Christine A, Aguhob, Aaron, Shirley, Kristie, Rong, Lijun, Rehman, Jalees, Malik, Asrar B, Procko, Erik
Published in EMBO molecular medicine (08.11.2022)
Published in EMBO molecular medicine (08.11.2022)
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Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation
Skeeters, Savanna, Bagale, Kamal, Stepanyuk, Galina, Thieker, David, Aguhob, Aaron, Chan, Kui K., Dutzar, Benjamin, Shalygin, Sergei, Shajahan, Asif, Yang, Xu, DaRosa, Paul A., Frazier, Emily, Sauer, Maximilian M., Bogatzki, Lisa, Byrnes-Blake, Kelly A., Song, Yifan, Azadi, Parastoo, Tarcha, Eric, Zhang, Lianghui, Procko, Erik
Published in Molecular therapy. Methods & clinical development (12.09.2024)
Published in Molecular therapy. Methods & clinical development (12.09.2024)
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Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization
Chan, Kui K, Wood, B. McKay, Fedorov, Alexander A, Fedorov, Elena V, Imker, Heidi J, Amyes, Tina L, Richard, John P, Almo, Steven C, Gerlt, John A
Published in Biochemistry (Easton) (23.06.2009)
Published in Biochemistry (Easton) (23.06.2009)
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An Examination of the Relationship between Active Site Loop Size and Thermodynamic Activation Parameters for Orotidine 5′-Monophosphate Decarboxylase from Mesophilic and Thermophilic Organisms
Toth, Krisztina, Amyes, Tina L, Wood, B. McKay, Chan, Kui K, Gerlt, John A, Richard, John P
Published in Biochemistry (Easton) (25.08.2009)
Published in Biochemistry (Easton) (25.08.2009)
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An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants
Chan, Kui K, Tan, Timothy J C, Narayanan, Krishna K, Procko, Erik
Published in Science advances (17.02.2021)
Published in Science advances (17.02.2021)
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Introduction of a polar core into the de novo designed protein Top7
Basanta, Benjamin, Chan, Kui K., Barth, Patrick, King, Tiffany, Sosnick, Tobin R., Hinshaw, James R., Liu, Gaohua, Everett, John K., Xiao, Rong, Montelione, Gaetano T., Baker, David
Published in Protein science (01.07.2016)
Published in Protein science (01.07.2016)
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Structural Basis for Substrate Specificity in Phosphate Binding (β/α)8-Barrels: d-Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12
Chan, Kui K, Fedorov, Alexander A, Fedorov, Elena V, Almo, Steven C, Gerlt, John A
Published in Biochemistry (Easton) (09.09.2008)
Published in Biochemistry (Easton) (09.09.2008)
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An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2
Zhang, Lianghui, Narayanan, Krishna K, Cooper, Laura, Chan, Kui K, Devlin, Christine A, Aguhob, Aaron, Shirley, Kristie, Rong, Lijun, Rehman, Jalees, Malik, Asrar B, Procko, Erik
Published in bioRxiv (28.03.2022)
Published in bioRxiv (28.03.2022)
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Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants
Zhang, Lianghui, Dutta, Soumajit, Xiong, Shiqin, Chan, Matthew, Chan, Kui K, Fan, Timothy M, Bailey, Keith L, Lindeblad, Matthew, Cooper, Laura M, Rong, Lijun, Gugliuzza, Anthony F, Shukla, Diwakar, Procko, Erik, Rehman, Jalees, Malik, Asrar B
Published in bioRxiv (22.12.2021)
Published in bioRxiv (22.12.2021)
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Paper
Introduction of a polar core into the de novo designed protein T op7
Basanta, Benjamin, Chan, Kui K., Barth, Patrick, King, Tiffany, Sosnick, Tobin R., Hinshaw, James R., Liu, Gaohua, Everett, John K., Xiao, Rong, Montelione, Gaetano T., Baker, David
Published in Protein science (01.07.2016)
Published in Protein science (01.07.2016)
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SOLUBLE ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) PROTEINS AND ACE2 FUSION PROTEINS
DUTZAR, Benjamin, TARCHA, Eric, THIEKER, David, PROCKO, Erik, SKEETERS, Savanna, CHAN, Kui K, STEPANYUK, Galina, SONG, Yifan, AGUHOB, Aaron
Year of Publication 13.06.2024
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Year of Publication 13.06.2024
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