Regulation of Adhesion Dynamics by Calpain-mediated Proteolysis of Focal Adhesion Kinase (FAK)
Chan, Keefe T., Bennin, David A., Huttenlocher, Anna
Published in The Journal of biological chemistry (09.04.2010)
Published in The Journal of biological chemistry (09.04.2010)
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FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion
Chan, Keefe T, Cortesio, Christa L, Huttenlocher, Anna
Published in The Journal of cell biology (20.04.2009)
Published in The Journal of cell biology (20.04.2009)
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Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma
AbuHammad, Shatha, Cullinane, Carleen, Martin, Claire, Bacolas, Zoe, Ward, Teresa, Chen, Huiqin, Slater, Alison, Ardley, Kerry, Kirby, Laura, Chan, Keefe T., Brajanovski, Natalie, Smith, Lorey K., Rao, Aparna D., Lelliott, Emily J., Kleinschmidt, Margarete, Vergara, Ismael A., Papenfuss, Anthony T., Lau, Peter, Ghosh, Prerana, Haupt, Sue, Haupt, Ygal, Sanij, Elaine, Poortinga, Gretchen, Pearson, Richard B., Falk, Hendrik, Curtis, David J., Stupple, Paul, Devlin, Mark, Street, Ian, Davies, Michael A., McArthur, Grant A., Sheppard, Karen E.
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2019)
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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., Pearson, Richard B.
Published in Nature communications (26.05.2020)
Published in Nature communications (26.05.2020)
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A functional genetic screen defines the AKT-induced senescence signaling network
Chan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian, Trigos, Anna S., Madhamshettiwar, Piyush B., Diesch, Jeannine, Paavolainen, Lassi, Horvath, Peter, Hannan, Ross D., George, Amee J., Sanij, Elaine, Hannan, Katherine M., Simpson, Kaylene J., Pearson, Richard B.
Published in Cell death and differentiation (01.02.2020)
Published in Cell death and differentiation (01.02.2020)
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LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma
Liu, Wenjin, Monahan, Kimberly B., Pfefferle, Adam D., Shimamura, Takeshi, Sorrentino, Jessica, Chan, Keefe T., Roadcap, David W., Ollila, David W., Thomas, Nancy E., Castrillon, Diego H., Miller, C. Ryan, Perou, Charles M., Wong, Kwok-Kin, Bear, James E., Sharpless, Norman E.
Published in Cancer cell (12.06.2012)
Published in Cancer cell (12.06.2012)
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Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
Quin, Jaclyn, Chan, Keefe T, Devlin, Jennifer R, Cameron, Donald P, Diesch, Jeannine, Cullinane, Carleen, Ahern, Jessica, Khot, Amit, Hein, Nadine, George, Amee J, Hannan, Katherine M, Poortinga, Gretchen, Sheppard, Karen E, Khanna, Kum Kum, Johnstone, Ricky W, Drygin, Denis, McArthur, Grant A, Pearson, Richard B, Sanij, Elaine, Hannan, Ross D
Published in Oncotarget (02.08.2016)
Published in Oncotarget (02.08.2016)
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Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation
Zhu, Haoran, Chan, Keefe T, Huang, Xinran, Cerra, Carmelo, Blake, Shaun, Trigos, Anna S, Anderson, Dovile, Creek, Darren J, De Souza, David P, Wang, Xi, Fu, Caiyun, Jana, Metta, Sanij, Elaine, Pearson, Richard B, Kang, Jian
Published in eLife (27.06.2022)
Published in eLife (27.06.2022)
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Journal Article
The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer
Yan, Shunfei, Frank, Daniel, Son, Jinbae, Hannan, Katherine M, Hannan, Ross D, Chan, Keefe T, Pearson, Richard B, Sanij, Elaine
Published in International journal of molecular sciences (20.01.2017)
Published in International journal of molecular sciences (20.01.2017)
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Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin
Chan, Keefe T, Roadcap, David W, Holoweckyj, Nicholas, Bear, James E
Published in Biochemical journal (15.05.2012)
Published in Biochemical journal (15.05.2012)
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Cystathionine β-Synthase in Physiology and Cancer
Pearson, Richard B., Chan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian
Published in BioMed research international (01.01.2018)
Published in BioMed research international (01.01.2018)
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Journal Article
Oncogene-induced senescence: From biology to therapy
Zhu, Haoran, Blake, Shaun, Kusuma, Frances K, Pearson, Richard B, Kang, Jian, Chan, Keefe T
Published in Mechanisms of ageing and development (01.04.2020)
Published in Mechanisms of ageing and development (01.04.2020)
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INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors
Dietrich, Catherine, Trub, Alec, Ahn, Antonio, Taylor, Michael, Ambani, Krutika, Chan, Keefe T, Lu, Kun-Hui, Mahendra, Christabella A, Blyth, Catherine, Coulson, Rhiannon, Ramm, Susanne, Watt, April C, Matsa, Sunil Kumar, Bisi, John, Strum, Jay, Roberts, Patrick, Goel, Shom
Published in Cancer discovery (01.03.2024)
Published in Cancer discovery (01.03.2024)
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The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer
Yan, Shunfei, Xuan, Jiachen, Brajanovski, Natalie, Tancock, Madeleine R. C., Madhamshettiwar, Piyush B., Simpson, Kaylene J., Ellis, Sarah, Kang, Jian, Cullinane, Carleen, Sheppard, Karen E., Hannan, Katherine M., Hannan, Ross D., Sanij, Elaine, Pearson, Richard B., Chan, Keefe T.
Published in British journal of cancer (02.02.2021)
Published in British journal of cancer (02.02.2021)
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β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion
Creed, Sarah J, Le, Caroline P, Hassan, Mona, Pon, Cindy K, Albold, Sabine, Chan, Keefe T, Berginski, Matthew E, Huang, Zhendong, Bear, James E, Lane, J Robert, Halls, Michelle L, Ferrari, Davide, Nowell, Cameron J, Sloan, Erica K
Published in Breast cancer research : BCR (25.11.2015)
Published in Breast cancer research : BCR (25.11.2015)
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Journal Article
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion
Cortesio, Christa L, Chan, Keefe T, Perrin, Benjamin J, Burton, Nicholas O, Zhang, Sheng, Zhang, Zhong-Yin, Huttenlocher, Anna
Published in The Journal of cell biology (10.03.2008)
Published in The Journal of cell biology (10.03.2008)
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Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis
Kusnadi, Eric P, Trigos, Anna S, Cullinane, Carleen, Goode, David L, Larsson, Ola, Devlin, Jennifer R, Chan, Keefe T, De Souza, David P, McConville, Malcolm J, McArthur, Grant A, Thomas, George, Sanij, Elaine, Poortinga, Gretchen, Hannan, Ross D, Hannan, Katherine M, Kang, Jian, Pearson, Richard B
Published in The EMBO journal (02.11.2020)
Published in The EMBO journal (02.11.2020)
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LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues
Chan, Keefe T, Asokan, Sreeja B, King, Samantha J, Bo, Tao, Dubose, Evan S, Liu, Wenjin, Berginski, Matthew E, Simon, Jeremy M, Davis, Ian J, Gomez, Shawn M, Sharpless, Norman E, Bear, James E
Published in The Journal of cell biology (27.10.2014)
Published in The Journal of cell biology (27.10.2014)
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