Roles for Pbp1 and Caloric Restriction in Genome and Lifespan Maintenance via Suppression of RNA-DNA Hybrids
Salvi, Jayesh S., Chan, Janet N.Y., Szafranski, Kirk, Liu, Tony T., Wu, Jane D., Olsen, Jonathan B., Khanam, Nurussaba, Poon, Betty P.K., Emili, Andrew, Mekhail, Karim
Published in Developmental cell (28.07.2014)
Published in Developmental cell (28.07.2014)
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Nucleolar RNA polymerase II drives ribosome biogenesis
Abraham, Karan J, Khosraviani, Negin, Chan, Janet N Y, Gorthi, Aparna, Samman, Anas, Zhao, Dorothy Y, Wang, Miling, Bokros, Michael, Vidya, Elva, Ostrowski, Lauren A, Oshidari, Roxanne, Pietrobon, Violena, Patel, Parasvi S, Algouneh, Arash, Singhania, Rajat, Liu, Yupeng, Yerlici, V Talya, De Carvalho, Daniel D, Ohh, Michael, Dickson, Brendan C, Hakem, Razq, Greenblatt, Jack F, Lee, Stephen, Bishop, Alexander J R, Mekhail, Karim
Published in Nature (London) (10.09.2020)
Published in Nature (London) (10.09.2020)
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Recent advances and method development for drug target identification
Chan, Janet N.Y, Nislow, Corey, Emili, Andrew
Published in Trends in pharmacological sciences (Regular ed.) (01.02.2010)
Published in Trends in pharmacological sciences (Regular ed.) (01.02.2010)
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Journal Article
Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process
Chung, Daniel K C, Chan, Janet N Y, Strecker, Jonathan, Zhang, Wei, Ebrahimi-Ardebili, Sasha, Lu, Thomas, Abraham, Karan J, Durocher, Daniel, Mekhail, Karim
Published in Nature communications (24.07.2015)
Published in Nature communications (24.07.2015)
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Journal Article
SARS-CoV-2 targets ribosomal RNA biogenesis
Yerlici, V. Talya, Astori, Audrey, Kejiou, Nevraj S., Jordan, Chris A., Khosraviani, Negin, Chan, Janet N.Y., Hakem, Razqallah, Raught, Brian, Palazzo, Alexander F., Mekhail, Karim
Published in Cell reports (Cambridge) (26.03.2024)
Published in Cell reports (Cambridge) (26.03.2024)
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Journal Article
RNA-cDNA hybrids mediate transposition via different mechanisms
Todd, Lauren A, Hall, Amanda C, Pietrobon, Violena, Chan, Janet N Y, Laflamme, Guillaume, Mekhail, Karim
Published in Scientific reports (29.09.2020)
Published in Scientific reports (29.09.2020)
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Journal Article
Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids
Abraham, Karan J, Chan, Janet N Y, Salvi, Jayesh S, Ho, Brandon, Hall, Amanda, Vidya, Elva, Guo, Ru, Killackey, Samuel A, Liu, Nancy, Lee, Jeffrey E, Brown, Grant W, Mekhail, Karim
Published in Nucleic acids research (14.10.2016)
Published in Nucleic acids research (14.10.2016)
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Protocol to use RNaseH1-based CRISPR to modulate locus-associated R-loops
Khosraviani, Negin, Abraham, Karan J., Chan, Janet N.Y., Mekhail, Karim
Published in STAR protocols (16.12.2022)
Published in STAR protocols (16.12.2022)
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Target Identification by Chromatographic Co-elution: Monitoring of Drug-Protein Interactions without Immobilization or Chemical Derivatization
Chan, Janet N.Y., Vuckovic, Dajana, Sleno, Lekha, Olsen, Jonathan B., Pogoutse, Oxana, Havugimana, Pierre, Hewel, Johannes A., Bajaj, Navgeet, Wang, Yale, Musteata, Marcel F., Nislow, Corey, Emili, Andrew
Published in Molecular & cellular proteomics (01.07.2012)
Published in Molecular & cellular proteomics (01.07.2012)
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Journal Article
Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair
Oshidari, Roxanne, Strecker, Jonathan, Chung, Daniel K C, Abraham, Karan J, Chan, Janet N Y, Damaren, Christopher J, Mekhail, Karim
Published in Nature communications (02.07.2018)
Published in Nature communications (02.07.2018)
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Journal Article
DNA double-strand break-capturing nuclear envelope tubules drive DNA repair
Shokrollahi, Mitra, Stanic, Mia, Hundal, Anisha, Chan, Janet N Y, Urman, Defne, Jordan, Chris A, Hakem, Anne, Espin, Roderic, Hao, Jun, Krishnan, Rehna, Maass, Philipp G, Dickson, Brendan C, Hande, Manoor P, Pujana, Miquel A, Hakem, Razqallah, Mekhail, Karim
Published in Nature structural & molecular biology (01.09.2024)
Published in Nature structural & molecular biology (01.09.2024)
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Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats
Ostrowski, Lauren A, Hall, Amanda C, Szafranski, Kirk J, Oshidari, Roxanne, Abraham, Karan J, Chan, Janet N Y, Krustev, Christian, Zhang, Kevin, Wang, Ashley, Liu, Yupeng, Guo, Ru, Mekhail, Karim
Published in Communications biology (01.01.2018)
Published in Communications biology (01.01.2018)
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