Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy
Lim, Sean H., Vaughan, Andrew T., Ashton-Key, Margaret, Williams, Emily L., Dixon, Sandra V., Chan, H. T. Claude, Beers, Stephen A., French, Ruth R., Cox, Kerry L., Davies, Andrew J., Potter, Kathleen N., Mockridge, C. Ian, Oscier, David G., Johnson, Peter W.M., Cragg, Mark S., Glennie, Martin J.
Published in Blood (01.09.2011)
Published in Blood (01.09.2011)
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Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments
Moreno-Vicente, Julia, Willoughby, Jane E, Taylor, Martin C, Booth, Steven G, English, Vikki L, Williams, Emily L, Penfold, Christine A, Mockridge, C Ian, Inzhelevskaya, Tatyana, Kim, Jinny, Chan, H T Claude, Cragg, Mark S, Gray, Juliet C, Beers, Stephen A
Published in Journal for immunotherapy of cancer (01.01.2022)
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TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
Yu, Xiaojie, James, Sonya, Felce, James H., Kellermayer, Blanka, Johnston, David A., Chan, H. T. Claude, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, Watanabe, Yasunori, Crispin, Max, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., Glennie, Martin J., Cragg, Mark S.
Published in Communications biology (23.06.2021)
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Induction of Cytosolic Calcium Flux by CD20 Is Dependent upon B Cell Antigen Receptor Signaling
Walshe, Claire A., Beers, Stephen A., French, Ruth R., Chan, Claude H.T., Johnson, Peter W., Packham, Graham K., Glennie, Martin J., Cragg, Mark S.
Published in The Journal of biological chemistry (20.06.2008)
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Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering
Heckel, Franziska, Turaj, Anna H., Fisher, Hayden, Chan, H. T. Claude, Marshall, Michael J. E., Dadas, Osman, Penfold, Christine A., Inzhelevskaya, Tatyana, Mockridge, C. Ian, Alvarado, Diego, Tews, Ivo, Keler, Tibor, Beers, Stephen A., Cragg, Mark S., Lim, Sean H.
Published in Communications biology (14.03.2022)
Published in Communications biology (14.03.2022)
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Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms
Cleary, Kirstie L S, Chan, H T Claude, James, Sonja, Glennie, Martin J, Cragg, Mark S
Published in The Journal of immunology (1950) (15.05.2017)
Published in The Journal of immunology (1950) (15.05.2017)
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Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies
Alduaij, Waleed, Ivanov, Andrei, Honeychurch, Jamie, Cheadle, Eleanor J., Potluri, Sandeep, Lim, Sean H., Shimada, Kazuyuki, Chan, Claude H.T., Tutt, Alison, Beers, Stephen A., Glennie, Martin J., Cragg, Mark S., Illidge, Tim M.
Published in Blood (28.04.2011)
Published in Blood (28.04.2011)
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Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function
Buchan, Sarah L., Dou, Lang, Remer, Marcus, Booth, Steven G., Dunn, Stuart N., Lai, Chester, Semmrich, Monika, Teige, Ingrid, Mårtensson, Linda, Penfold, Christine A., Chan, H.T. Claude, Willoughby, Jane E., Mockridge, C. Ian, Dahal, Lekh N., Cleary, Kirstie L.S., James, Sonya, Rogel, Anne, Kannisto, Päivi, Jernetz, Mats, Williams, Emily L., Healy, Eugene, Verbeek, J. Sjef, Johnson, Peter W.M., Frendéus, Björn, Cragg, Mark S., Glennie, Martin J., Gray, Juliet C., Al-Shamkhani, Aymen, Beers, Stephen A.
Published in Immunity (Cambridge, Mass.) (20.11.2018)
Published in Immunity (Cambridge, Mass.) (20.11.2018)
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Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection
Beers, Stephen A., French, Ruth R., Chan, H.T. Claude, Lim, Sean H., Jarrett, Timothy C., Vidal, Regina Mora, Wijayaweera, Sahan S., Dixon, Sandra V., Kim, Hyungjin, Cox, Kerry L., Kerr, Jonathan P., Johnston, David A., Johnson, Peter W.M., Verbeek, J. Sjef, Glennie, Martin J., Cragg, Mark S.
Published in Blood (24.06.2010)
Published in Blood (24.06.2010)
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Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4‐1BB), and their role in the generation of anti‐tumor immune responses
Taraban, Vadim Y., Rowley, Tania F., O'Brien, Lyn, Chan, H. T. Claude, Haswell, Linsey E., Green, Michael H. A., Tutt, Alison L., Glennie, Martin J., Al‐Shamkhani, Aymen
Published in European journal of immunology (01.12.2002)
Published in European journal of immunology (01.12.2002)
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Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation
Beers, Stephen A., Chan, Claude H.T., James, Sonya, French, Ruth R., Attfield, Kathrine E., Brennan, Claire M., Ahuja, Anupama, Shlomchik, Mark J., Cragg, Mark S., Glennie, Martin J.
Published in Blood (15.11.2008)
Published in Blood (15.11.2008)
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Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I Monoclonal Antibody Efficacy
Dahal, Lekh N, Huang, Chie-Yin, Stopforth, Richard J, Mead, Abbie, Chan, Keith, Bowater, Juliet X, Taylor, Martin C, Narang, Priyanka, Chan, H T Claude, Kim, Jinny H, Vaughan, Andrew T, Forconi, Francesco, Beers, Stephen A
Published in The Journal of immunology (1950) (15.08.2018)
Published in The Journal of immunology (1950) (15.08.2018)
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Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc
Dadas, Osman, Allen, Joel D, Buchan, Sarah L, Kim, Jinny, Chan, H T Claude, Mockridge, C Ian, Duriez, Patrick J, Rogel, Anne, Crispin, Max, Al-Shamkhani, Aymen
Published in Frontiers in immunology (27.10.2023)
Published in Frontiers in immunology (27.10.2023)
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CD20 as a target for therapeutic type I and II monoclonal antibodies
Beers, Stephen A, Chan, Claude H T, French, Ruth R, Cragg, Mark S, Glennie, Martin J
Published in Seminars in hematology (01.04.2010)
Published in Seminars in hematology (01.04.2010)
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Detection of Experimental and Clinical Immune Complexes by Measuring SHIP-1 Recruitment to the Inhibitory FcγRIIB
Stopforth, Richard J, Oldham, Robert J, Tutt, Alison L, Duriez, Patrick, Chan, H T Claude, Binkowski, Brock F, Zimprich, Chad, Li, Dun, Hargreaves, Philip G, Cong, Mei, Reddy, Venkat, Leandro, Maria J, Cambridge, Geraldine, Lux, Anja, Nimmerjahn, Falk, Cragg, Mark S
Published in The Journal of immunology (1950) (01.03.2018)
Published in The Journal of immunology (1950) (01.03.2018)
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LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation
Yeboah, Muchaala, Papagregoriou, Charys, Jones, Des C, Chan, H T Claude, Hu, Guangan, McPartlan, Justine S, Schiött, Torbjörn, Mattson, Ulrika, Mockridge, C Ian, Tornberg, Ulla-Carin, Hambe, Björn, Ljungars, Anne, Mattsson, Mikael, Tews, Ivo, Glennie, Martin J, Thirdborough, Stephen M, Trowsdale, John, Frendeus, Björn, Chen, Jianzhu, Cragg, Mark S, Roghanian, Ali
Published in JCI insight (01.09.2020)
Published in JCI insight (01.09.2020)
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FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion
Oldham, Robert J, Mockridge, C Ian, James, Sonya, Duriez, Patrick J, Chan, H T Claude, Cox, Kerry L, Pitic, Vicentiu A, Glennie, Martin J, Cragg, Mark S
Published in Journal for immunotherapy of cancer (01.06.2020)
Published in Journal for immunotherapy of cancer (01.06.2020)
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Immunotherapy targeting inhibitory Fcγ receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization
Williams, Emily L, Tutt, Alison L, Beers, Stephen A, French, Ruth R, Chan, Claude H T, Cox, Kerry L, Roghanian, Ali, Penfold, Christine A, Butts, Cherié L, Boross, Peter, Verbeek, J Sjef, Cragg, Mark S, Glennie, Martin J
Published in The Journal of immunology (1950) (15.10.2013)
Published in The Journal of immunology (1950) (15.10.2013)
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Domain binding and isotype dictate the activity of anti-human OX40 antibodies
Griffiths, Jordana, Hussain, Khiyam, Smith, Hannah L, Sanders, Theodore, Cox, Kerry L, Semmrich, Monika, Mårtensson, Linda, Kim, Jinny, Inzhelevskaya, Tatyana, Penfold, Chris A, Tutt, Alison L, Mockridge, C Ian, Chan, HT Claude, English, Vikki, French, Ruth F, Teige, Ingrid, Al-Shamkhani, Aymen, Glennie, Martin J, Frendeus, Bjorn L, Willoughby, Jane E, Cragg, Mark S
Published in Journal for immunotherapy of cancer (01.12.2020)
Published in Journal for immunotherapy of cancer (01.12.2020)
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Reducing affinity as a strategy to boost immunomodulatory antibody agonism
Yu, Xiaojie, Orr, Christian M., Chan, H. T. Claude, James, Sonya, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, Cox, Kerry L., Essex, Jonathan W., Tews, Ivo, Glennie, Martin J., Cragg, Mark S.
Published in Nature (London) (16.02.2023)
Published in Nature (London) (16.02.2023)
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