Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction
England, Elizabeth, Rees, D Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T Y, Chaillan Huntington, Catherine E, Houslay, Kirsty F, Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B, Rapley, Laura, Sims, Dorothy A, Hollins, Claire, Hinchy, Elizabeth C, Strain, Martin D, Kemp, Benjamin P, Corkill, Dominic J, May, Richard D, Vousden, Katherine A, Butler, Robin J, Mustelin, Tomas, Vaughan, Tristan J, Lowe, David C, Colley, Caroline, Cohen, E Suzanne
Published in Scientific reports (17.06.2023)
Published in Scientific reports (17.06.2023)
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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
Cohen, E Suzanne, Scott, Ian C, Majithiya, Jayesh B, Rapley, Laura, Kemp, Benjamin P, England, Elizabeth, Rees, D Gareth, Overed-Sayer, Catherine L, Woods, Joanne, Bond, Nicholas J, Veyssier, Christel Séguy, Embrey, Kevin J, Sims, Dorothy A, Snaith, Michael R, Vousden, Katherine A, Strain, Martin D, Chan, Denice T Y, Carmen, Sara, Huntington, Catherine E, Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E, Vaughan, Tristan J, Butler, Robin, Lowe, David C, Higazi, Daniel R, Corkill, Dominic J, May, Richard D, Sleeman, Matthew A, Mustelin, Tomas
Published in Nature communications (14.09.2015)
Published in Nature communications (14.09.2015)
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Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation
Chan, Denice T. Y., Jenkinson, Lesley, Haynes, Stuart W., Austin, Mark, Diamandakis, Agata, Burschowsky, Daniel, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
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Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils
Zhou, Yebin, Chen, Bo, Mittereder, Nanette, Chaerkady, Raghothama, Strain, Martin, An, Ling-Ling, Rahman, Saifur, Ma, Wenting, Low, Choon Pei, Chan, Denice, Neal, Frances, Bingham, 3rd, Clifton O, Sampson, Kevon, Darrah, Erika, Siegel, Richard M, Hasni, Sarfaraz, Andrade, Felipe, Vousden, Katherine A, Mustelin, Tomas, Sims, Gary P
Published in Frontiers in immunology (25.09.2017)
Published in Frontiers in immunology (25.09.2017)
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Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action
Austin, Mark, Burschowsky, Daniel, Chan, Denice T Y, Jenkinson, Lesley, Haynes, Stuart, Diamandakis, Agata, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H, Hadjinicolaou, Andreas V, Gileadi, Uzi, Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Kaserer, Teresa, Sharma, Pooja, Luheshi, Nadia M, Wilkinson, Robert W, Vaughan, Tristan J, Holt, Sarah V, Cerundolo, Vincenzo, Carr, Mark D, Groves, Maria A T
Published in mAbs (01.01.2020)
Published in mAbs (01.01.2020)
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Activation of Nippostrongylus brasiliensis infective larvae is regulated by a pathway distinct from the hookworm Ancylostoma caninum
Huang, Stanley Ching-Cheng, Chan, Denice Tsz Yau, Smyth, Danielle J., Ball, Glyn, Gounaris, Kleoniki, Selkirk, Murray E.
Published in International journal for parasitology (01.12.2010)
Published in International journal for parasitology (01.12.2010)
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EPEN-14. GENERATION OF A C11orf95-RELA FUSION TARGETING ANTIBODY AS A DIAGNOSTIC TOOL FOR SUPRATENTORIAL EPENDYMOMA
Ruff, Lisa, Chan, Denice Y, Jenkinson, Lesley, Haynes, Stuart, Austin, Mark, Holt, Sarah, Groves, Maria, Gilbertson, Richard J
Published in Neuro-oncology (Charlottesville, Va.) (04.12.2020)
Published in Neuro-oncology (Charlottesville, Va.) (04.12.2020)
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Spontaneous secretion of peptidyl-arginine deiminase 2 and cell surface exposure of peptidyl-arginine deiminase 4 by neutrophils
Zhou, Yebin, Chen, Bo, Mittereder, Nanette, Chaerkady, Raghothama, Strain, Martin, Rahman, Saifur, Ma, Wenting, Low, Choon Pei, Chan, Denice, Neal, Frances, Bingham, Clifton O, Sampson, Kevon, Darrah, Erika, Bowen, Michael, Andrade, Felipe, Vousden, Katherine, Sims, Gary P, Mustelin, Tomas Mikael
Published in The Journal of immunology (1950) (01.05.2017)
Published in The Journal of immunology (1950) (01.05.2017)
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아르기나제 II(ARG2)에 대한 분자의 결합
HOLT SARAH, SHARMA POOJA, FIEDLER SEBASTIAN, GROVES MARIA, JENKINSON LESLEY, MCLAUGHLIN FIONA, HAYNES STUART, CHAN DENICE, WHITEHOUSE JESSICA, BURSCHOWSKY DANIEL, ADDYMAN ALEXANDRA, CERUNDOLO VINCENZO, DIAMANDAKIS AGATA, SHIBATA YOKO, SEEWOORUTHUN CHITRA, CARR MARK D, SLATER LOUISE, KESWICK STEPHANIE, AUSTIN MARK, BARNARD MICHELLE
Year of Publication 20.04.2022
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Year of Publication 20.04.2022
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IMMUNOTHERAPY FOR CANCER
GROVES, MARIA, ADDYMAN, ALEXANDRA, JENKINSON, LESLEY, CHAN, DENICE TSZ YAU, HAYNES, STUART, CHAPMAN, MICHAEL, LAPOINTE, JEAN-MARTIN, MARTIN, KIRSTY-JANE, VAUGHAN, TRISTAN, AUSTIN, MARK, BARNARD, MICHELLE, SLATER, LOUISE, ANDERSON, GEORGINA, DIAMANDAKIS, AGATA, HAWTHORNE, WILLIAM
Year of Publication 15.06.2023
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Year of Publication 15.06.2023
Patent
IMMUNOTHERAPY FOR CANCER
HAYNES, Stuart, SLATER, Louise, VAUGHAN, Tristan, ANDERSON, Georgina, JENKINSON, Lesley, LAPOINTE, Jean-Martin, DIAMANDAKIS, Agata, CHAN, Denice Tsz Yau, GROVES, Maria, AUSTIN, Mark, CHAPMAN, Michael, HAWTHORNE, William, BARNARD, Michelle, ADDYMAN, Alexandra, MARTIN, Kirsty-Jane
Year of Publication 15.06.2023
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Year of Publication 15.06.2023
Patent
BINDING MOLECULES TO ARGINASE II [ARG2]
Jenkinson, Lesley, Keswick, Stephanie, Carr, Mark D, Slater, Louise, Holt, Sarah, Shibata, Yoko, Fielder, Sebastian, Addyman, Alexandra, Burschowsky, Daniel, Whitehouse, Jessica, Sharma, Pooja, Chan, Denice, Austin, Mark, Haynes, Stuart, Groves, Maria, McLaughlin, Fiona, Seewooruthun, Chitra, Diamandakis, Agata, Barnard, Michelle, Cerundolo, Vincenzo
Year of Publication 22.12.2022
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Year of Publication 22.12.2022
Patent
BINDING MOLECULES TO ARGINASE II (ARG2)
HAYNES, Stuart, SLATER, Louise, SHARMA, Pooja, SEEWOORUTHUN, Chitra, BURSCHOWSKY, Daniel, CHAN, Denice, JENKINSON, Lesley, FIEDLER, Sebastian, DIAMANDAKIS, Agata, GROVES, Maria, SHIBATA, Yoko, AUSTIN, Mark, WHITEHOUSE, Jessica, HOLT, Sarah, MCLAUGHLIN, Fiona, CARR, Mark D, BARNARD, Michelle, ADDYMAN, Alexandra, KESWICK, Stephanie, CERUNDOLO, Vincenzo
Year of Publication 29.06.2022
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Year of Publication 29.06.2022
Patent
Tozorakimab (MEDI3506): a dual-pharmacology anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction
England, Elizabeth, Rees, D Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T Y, Chaillan Huntington, Catherine E, Houslay, Kirsty F, Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B, Rapley, Laura, Sims, Dorothy A, Hollins, Claire, Hinchy, Elizabeth C, Strain, Martin D, Kemp, Benjamin P, Corkill, Dominic J, May, Richard D, Vousden, Katherine A, Butler, Robin J, Mustelin, Tomas, Vaughan, Tristan J, Lowe, David C, Colley, Caroline, Cohen, E Suzanne
Published in bioRxiv (01.03.2023)
Published in bioRxiv (01.03.2023)
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Paper
BINDING MOLECULES TO ARGINASE II (ARG2)
HAYNES, Stuart, SLATER, Louise, SHARMA, Pooja, SEEWOORUTHUN, Chitra, BURSCHOWSKY, Daniel, CHAN, Denice, JENKINSON, Lesley, FIEDLER, Sebastian, DIAMANDAKIS, Agata, GROVES, Maria, SHIBATA, Yoko, AUSTIN, Mark, WHITEHOUSE, Jessica, HOLT, Sarah, MCLAUGHLIN, Fiona, CARR, Mark D, BARNARD, Michelle, ADDYMAN, Alexandra, KESWICK, Stephanie, CERUNDOLO, Vincenzo
Year of Publication 25.02.2021
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Year of Publication 25.02.2021
Patent
Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action
Austin, Mark, Burschowsky, Daniel, Chan, Denice T.Y., Jenkinson, Lesley, Haynes, Stuart, Diamandakis, Agata, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Hadjinicolaou, Andreas V., Gileadi, Uzi, Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Kaserer, Teresa, Sharma, Pooja, Luheshi, Nadia M., Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.
Published in mAbs (01.01.2020)
Published in mAbs (01.01.2020)
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