Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
Yuan, Shuofeng, Yin, Xin, Meng, Xiangzhi, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Riva, Laura, Pache, Lars, Chan, Chris Chun-Yiu, Lai, Pok-Man, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lee, Andrew Chak-Yiu, Matsunaga, Naoko, Pu, Yuan, Yuen, Chun-Kit, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Sheng, Li, Du, Yushen, Xu, Wan, Lau, Chit-Ying, Sit, Ko-Yung, Au, Wing-Kuk, Wang, Runming, Zhang, Yu-Yuan, Tang, Yan-Dong, Clausen, Thomas Mandel, Pihl, Jessica, Oh, Juntaek, Sze, Kong-Hung, Zhang, Anna Jinxia, Chu, Hin, Kok, Kin-Hang, Wang, Dong, Cai, Xue-Hui, Esko, Jeffrey D., Hung, Ivan Fan-Ngai, Li, Ronald Adolphus, Chen, Honglin, Sun, Hongzhe, Jin, Dong-Yan, Sun, Ren, Chanda, Sumit K., Yuen, Kwok-Yung
Published in Nature (London) (20.05.2021)
Published in Nature (London) (20.05.2021)
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Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters
Yuan, Shuofeng, Ye, Zi-Wei, Liang, Ronghui, Tang, Kaiming, Zhang, Anna Jinxia, Lu, Gang, Ong, Chon Phin, Man Poon, Vincent Kwok, Chan, Chris Chung-Sing, Mok, Bobo Wing-Yee, Qin, Zhenzhi, Xie, Yubin, Chu, Allen Wing-Ho, Chan, Wan-Mui, Ip, Jonathan Daniel, Sun, Haoran, Tsang, Jessica Oi-Ling, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Lu, Lu, Yip, Cyril Chik-Yan, Chu, Hin, To, Kelvin Kai-Wang, Chen, Honglin, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Published in Science (American Association for the Advancement of Science) (22.07.2022)
Published in Science (American Association for the Advancement of Science) (22.07.2022)
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SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Qiao, Wei, Lau, Hui En, Xie, Huizhi, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Chu, Hin, Yuan, Shuofeng, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Yuen, Kwok-Yung, Cheung, Kenneth Man-Chee, Chan, Jasper Fuk-Woo, Yeung, Kelvin Wai-Kwok
Published in Nature communications (09.05.2022)
Published in Nature communications (09.05.2022)
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Journal Article
A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge
Zhou, Biao, Zhou, Runhong, Tang, Bingjie, Chan, Jasper Fuk-Woo, Luo, Mengxiao, Peng, Qiaoli, Yuan, Shuofeng, Liu, Hang, Mok, Bobo Wing-Yee, Chen, Bohao, Wang, Pui, Poon, Vincent Kwok-Man, Chu, Hin, Chan, Chris Chung-Sing, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Au, Ka-Kit, Man, Hiu-On, Lu, Lu, To, Kelvin Kai-Wang, Chen, Honglin, Yuen, Kwok-Yung, Dang, Shangyu, Chen, Zhiwei
Published in Nature communications (23.06.2022)
Published in Nature communications (23.06.2022)
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Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)
Yuan, Shuofeng, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Cai, Jian-Piao, Ye, Zi-Wei, Yin, Feifei, To, Kelvin Kai-Wang, Chu, Hin, Jin, Dong-Yan, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Published in Viruses (10.06.2020)
Published in Viruses (10.06.2020)
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Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection
Ye, Zi-Wei, Yuan, Shuofeng, Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yu, Ching-Yun, Ong, Chon Phin, Yang, Dong, Chan, Chris Chun-Yiu, Tang, Kaiming, Cao, Jianli, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Chu, Hin, Yuen, Kwok-Yung, Jin, Dong-Yan
Published in Emerging microbes & infections (01.01.2021)
Published in Emerging microbes & infections (01.01.2021)
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In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor
Wen, Lei, Tang, Kaiming, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Tsang, Jessica Oi-Ling, Liang, Ronghui, Cao, Jianli, Huang, Yaoqiang, Luo, Cuiting, Cai, Jian-Piao, Ye, Zi-Wei, Yin, Feifei, Chu, Hin, Jin, Dong-Yan, Yuen, Kwok-Yung, Yuan, Shuofeng, Chan, Jasper Fuk-Woo
Published in International journal of biological sciences (01.01.2021)
Published in International journal of biological sciences (01.01.2021)
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Journal Article
Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway
Yan, Bingpeng, Yuan, Shuofeng, Cao, Jianli, Fung, Kingchun, Lai, Pok-Man, Yin, Feifei, Sze, Kong-Hung, Qin, Zhenzhi, Xie, Yubin, Ye, Zi-Wei, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Zou, Zijiao, Chan, Chris Chun-Yiu, Luo, Cuiting, Cai, Jian-Piao, Chan, Kwok-Hung, Chung, Tom Wai-Hing, Tam, Anthony Raymond, Chu, Hin, Jin, Dong-Yan, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung, Kao, Richard Yi-Tsun, Chan, Jasper Fuk-Woo
Published in International journal of biological sciences (01.01.2022)
Published in International journal of biological sciences (01.01.2022)
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Journal Article
A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo
Chan, Jasper Fuk-Woo, Oh, Yoo Jin, Yuan, Shuofeng, Chu, Hin, Yeung, Man-Lung, Canena, Daniel, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Chan, Chris Chun-Yiu, Zhang, Anna Jinxia, Cai, Jian-Piao, Ye, Zi-Wei, Wen, Lei, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Shuai, Huiping, Wang, Yixin, Hou, Yuxin, Luo, Cuiting, Chan, Wan-Mui, Qin, Zhenzhi, Sit, Ko-Yung, Au, Wing-Kuk, Legendre, Maureen, Zhu, Rong, Hain, Lisa, Seferovic, Hannah, Tampé, Robert, To, Kelvin Kai-Wang, Chan, Kwok-Hung, Thomas, Dafydd Gareth, Klausberger, Miriam, Xu, Cheng, Moon, James J, Stadlmann, Johannes, Penninger, Josef M, Oostenbrink, Chris, Hinterdorfer, Peter, Yuen, Kwok-Yung, Markovitz, David M
Published in Cell reports. Medicine (18.10.2022)
Published in Cell reports. Medicine (18.10.2022)
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Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus
Yuan, Shuofeng, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Wen, Lei, Tsang, Terance Gi-Wai, Cao, Jianli, Huang, Jingjing, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Choi, Garnet Kwan-Yue, Cai, Jian-Piao, Yin, Feifei, Chu, Hin, Liang, Mifang, Jin, Dong-Yan, Yuen, Kwok-Yung
Published in Viruses (25.04.2019)
Published in Viruses (25.04.2019)
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Severe fever with thrombocytopenia syndrome virus (SFTSV)-host interactome screen identifies viral nucleoprotein-associated host factors as potential antiviral targets
Cao, Jianli, Lu, Gang, Wen, Lei, Luo, Peng, Huang, Yaoqiang, Liang, Ronghui, Tang, Kaiming, Qin, Zhenzhi, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Du, Jiang, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo, Yuan, Shuofeng
Published in Computational and structural biotechnology journal (01.01.2021)
Published in Computational and structural biotechnology journal (01.01.2021)
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A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters
Zhang, Bao-Zhong, Wang, Xiaolei, Yuan, Shuofeng, Li, Wenjun, Dou, Ying, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Chik, Kenn KaHeng, Tang, Kaiming, Chan, Chris Chun-Yiu, Hu, Ye-Fan, Hu, Jing-Chu, Badea, Smaranda Ruxandra, Gong, Hua-Rui, Lin, Xuansheng, Chu, Hin, Li, Xuechen, To, Kelvin Kai-Wang, Liu, Li, Chen, Zhiwei, Hung, Ivan Fan-Ngai, Yuen, Kwok Yung, Chan, Jasper Fuk-Woo, Huang, Jian-Dong
Published in Emerging microbes & infections (01.01.2021)
Published in Emerging microbes & infections (01.01.2021)
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Journal Article
Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells
Zou, Zijiao, Tsang, Jessica Oi-Ling, Yan, Bingpeng, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Yuen, Kwok-Yung
Published in Metabolites (23.07.2020)
Published in Metabolites (23.07.2020)
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Journal Article
Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies
Zhou, Dongyan, Chan, Jasper Fuk-Woo, Zhou, Biao, Zhou, Runhong, Li, Shuang, Shan, Sisi, Liu, Li, Zhang, Anna Jinxia, Chen, Serena J., Chan, Chris Chung-Sing, Xu, Haoran, Poon, Vincent Kwok-Man, Yuan, Shuofeng, Li, Cun, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cao, Jianli, Chan, Chun-Yin, Kwan, Ka-Yi, Du, Zhenglong, Lau, Thomas Tsz-Kan, Zhang, Qi, Zhou, Jie, To, Kelvin Kai-Wang, Zhang, Linqi, Ho, David D., Yuen, Kwok-Yung, Chen, Zhiwei
Published in Cell host & microbe (14.04.2021)
Published in Cell host & microbe (14.04.2021)
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Journal Article
Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters
Chan, Jasper Fuk Woo, Poon, Vincent Kwok Man, Chan, Chris Chung Sing, Chik, Kenn Ka Heng, Tsang, Jessica Oi Ling, Zou, Zijiao, Chan, Chris Chun Yiu, Lee, Andrew Chak Yiu, Li, Can, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Yuen, Terrence Tsz Tai, Hu, Bingjie, Huang, Xiner, Chai, Yue, Shuai, Huiping, Luo, Cuiting, Cai, Jian Piao, Chan, Kwok Hung, Sridhar, Siddharth, Yin, Feifei, Kok, Kin Hang, Chu, Hin, Zhang, Anna Jinxia, Yuan, Shuofeng, Yuen, Kwok Yung
Published in Clinical infectious diseases (24.08.2022)
Published in Clinical infectious diseases (24.08.2022)
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Journal Article
Targeting papain-like protease for broad-spectrum coronavirus inhibition
Yuan, Shuofeng, Gao, Xiaopan, Tang, Kaiming, Cai, Jian-Piao, Hu, Menglong, Luo, Peng, Wen, Lei, Ye, Zi-Wei, Luo, Cuiting, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Huang, Yaoqiang, Cao, Jianli, Liang, Ronghui, Qin, Zhenzhi, Qin, Bo, Yin, Feifei, Chu, Hin, Jin, Dong-Yan, Sun, Ren, Chan, Jasper Fuk-Woo, Cui, Sheng, Yuen, Kwok-Yung
Published in Protein & cell (01.12.2022)
Published in Protein & cell (01.12.2022)
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Journal Article
Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Qiao, Wei, Lau, Hui En, Xie, Huizhi, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Chu, Hin, Yuan, Shuofeng, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Yuen, Kwok-Yung, Cheung, Kenneth Man-Chee, Chan, Jasper Fuk-Woo, Yeung, Kelvin Wai-Kwok
Published in Nature communications (31.05.2022)
Published in Nature communications (31.05.2022)
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Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics
Chan, Chris Chun-Yiu, Guo, Qian, Chan, Jasper Fuk-Woo, Tang, Kaiming, Cai, Jian-Piao, Chik, Kenn Ka-Heng, Huang, Yixin, Dai, Mei, Qin, Bo, Ong, Chon Phin, Chu, Allen Wing-Ho, Chan, Wan-Mui, Ip, Jonathan Daniel, Wen, Lei, Tsang, Jessica Oi-Ling, Wang, Tong-Yun, Xie, Yubin, Qin, Zhenzhi, Cao, Jianli, Ye, Zi-Wei, Chu, Hin, To, Kelvin Kai-Wang, Ge, Xing-Yi, Ni, Tao, Jin, Dong-Yan, Cui, Sheng, Yuen, Kwok-Yung, Yuan, Shuofeng
Published in Acta pharmaceutica Sinica. B (01.09.2024)
Published in Acta pharmaceutica Sinica. B (01.09.2024)
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SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters1
Zhou, Biao, Zhou, Runhong, Jasper Fuk-Woo Chan, Zeng, Jianwei, Zhang, Qi, Yuan, Shuofeng, Liu, Li, Robinot, Rémy, Shan, Sisi, Liu, Na, Ge, Jiwan, Kwong, Hugo Yat-Hei, Zhou, Dongyan, Xu, Haoran, Chris Chung-Sing Chan, Poon, Vincent Kwok-Man, Chu, Hin, Yue, Ming, Ka-Yi, Kwan, Chun-Yin, Chan, Chris Chun-Yiu Chan, Kenn Ka-Heng Chik, Du, Zhenglong, Ka-Kit Au, Huang, Haode, Man, Hiu-On, Cao, Jianli, Li, Cun, Wang, Ziyi, Zhou, Jie, Song, Youqiang, Man-Lung Yeung, Kelvin Kai-Wang To, Ho, David D, Chakrabarti, Lisa A, Wang, Xinquan, Zhang, Linqi, Kwok-Yung, Yuen, Chen, Zhiwei
Published in Emerging microbes & infections (01.12.2023)
Published in Emerging microbes & infections (01.12.2023)
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Tailoring combinational therapy with Monte Carlo method-based regression modeling
Wang, Boqian, Yuan, Shuofeng, Chan, Chris Chun-Yiu, Tsang, Jessica Oi-Ling, He, Yiwu, Yuen, Kwok-Yung, Ding, Xianting, Chan, Jasper Fuk-Woo
Published in Fundamental research (Beijing) (01.04.2023)
Published in Fundamental research (Beijing) (01.04.2023)
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