High-resolution characterization of gene function using single-cell CRISPR tiling screen
Yang, Lu, Chan, Anthony K. N., Miyashita, Kazuya, Delaney, Christopher D., Wang, Xi, Li, Hongzhi, Pokharel, Sheela Pangeni, Li, Sandra, Li, Mingli, Xu, Xiaobao, Lu, Wei, Liu, Qiao, Mattson, Nicole, Chen, Kevin Yining, Wang, Jinhui, Yuan, Yate-Ching, Horne, David, Rosen, Steven T., Soto-Feliciano, Yadira, Feng, Zhaohui, Hoshii, Takayuki, Xiao, Gang, Müschen, Markus, Chen, Jianjun, Armstrong, Scott A., Chen, Chun-Wei
Published in Nature communications (01.07.2021)
Published in Nature communications (01.07.2021)
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METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation
Xue, Meilin, Dong, Lei, Zhang, Honghai, Li, Yangchan, Qiu, Kangqiang, Zhao, Zhicong, Gao, Min, Han, Li, Chan, Anthony K N, Li, Wei, Leung, Keith, Wang, Kitty, Pokharel, Sheela Pangeni, Qing, Ying, Liu, Wei, Wang, Xueer, Ren, Lili, Bi, Hongjie, Yang, Lu, Shen, Chao, Chen, Zhenhua, Melstrom, Laleh, Li, Hongzhi, Timchenko, Nikolai, Deng, Xiaolan, Huang, Wendong, Rosen, Steven T, Tian, Jingyan, Xu, Lin, Diao, Jiajie, Chen, Chun-Wei, Chen, Jianjun, Shen, Baiyong, Chen, Hao, Su, Rui
Published in Journal of hematology and oncology (01.02.2024)
Published in Journal of hematology and oncology (01.02.2024)
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3-Ketodihydrosphingosine reductase maintains ER homeostasis and unfolded protein response in leukemia
Liu, Qiao, Chan, Anthony K. N., Chang, Wen-Han, Yang, Lu, Pokharel, Sheela Pangeni, Miyashita, Kazuya, Mattson, Nicole, Xu, Xiaobao, Li, Mingli, Lu, Wei, Lin, Ren-Jang, Wang, Shao-Yuan, Chen, Chun-Wei
Published in Leukemia (01.01.2022)
Published in Leukemia (01.01.2022)
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A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens
Mattson, Nicole M., Chan, Anthony K. N., Miyashita, Kazuya, Mukhaleva, Elizaveta, Chang, Wen-Han, Yang, Lu, Ma, Ning, Wang, Yingyu, Pokharel, Sheela Pangeni, Li, Mingli, Liu, Qiao, Xu, Xiaobao, Chen, Renee, Singh, Priyanka, Zhang, Leisi, Elsayed, Zeinab, Chen, Bryan, Keen, Denise, Pirrotte, Patrick, Rosen, Steven. T., Chen, Jianjun, LaBarge, Mark A., Shively, John E., Vaidehi, Nagarajan, Rockne, Russell C., Feng, Mingye, Chen, Chun-Wei
Published in Nature structural & molecular biology (01.03.2024)
Published in Nature structural & molecular biology (01.03.2024)
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Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System
Pliotas, Christos, Grayer, Samuel C, Ekkerman, Silvia, Chan, Anthony K. N, Healy, Jess, Marius, Phedra, Bartlett, Wendy, Khan, Amjad, Cortopassi, Wilian A, Chandler, Shane A, Rasmussen, Tim, Benesch, Justin L. P, Paton, Robert S, Claridge, Timothy D. W, Miller, Samantha, Booth, Ian R, Naismith, James H, Conway, Stuart J
Published in Biochemistry (Easton) (15.08.2017)
Published in Biochemistry (Easton) (15.08.2017)
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Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition
Ng, Wai-Lung, Li, Ho-Chuen, Lau, Kit-Man, Chan, Anthony K. N., Lau, Clara Bik-San, Shing, Tony K. M.
Published in Scientific reports (17.07.2017)
Published in Scientific reports (17.07.2017)
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Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi
Laurin, Corentine M. C, Bluck, Joseph P, Chan, Anthony K. N, Keller, Michelle, Boczek, Andrew, Scorah, Amy R, See, K. F. Larissa, Jennings, Laura E, Hewings, David S, Woodhouse, Fern, Reynolds, Jessica K, Schiedel, Matthias, Humphreys, Philip G, Biggin, Philip C, Conway, Stuart J
Published in ACS infectious diseases (13.08.2021)
Published in ACS infectious diseases (13.08.2021)
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Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1‐EEF1A1 Axis
Li, Mingli, Yang, Lu, Chan, Anthony K. N., Pokharel, Sheela Pangeni, Liu, Qiao, Mattson, Nicole, Xu, Xiaobao, Chang, Wen‐Han, Miyashita, Kazuya, Singh, Priyanka, Zhang, Leisi, Li, Maggie, Wu, Jun, Wang, Jinhui, Chen, Bryan, Chan, Lai N., Lee, Jaewoong, Zhang, Xu Hannah, Rosen, Steven T., Müschen, Markus, Qi, Jun, Chen, Jianjun, Hiom, Kevin, Bishop, Alexander J. R., Chen, Chun‐Wei
Published in Advanced science (01.06.2023)
Published in Advanced science (01.06.2023)
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Small Molecule Ligands of the BET-like Bromodomain, SmBRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development
Schiedel, Matthias, McArdle, Darius J. B., Padalino, Gilda, Chan, Anthony K. N., Forde-Thomas, Josephine, McDonough, Michael, Whiteland, Helen, Beckmann, Manfred, Cookson, Rosa, Hoffmann, Karl F., Conway, Stuart J.
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Journal Article
Small Molecule Ligands of the BET-like Bromodomain, Sm BRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development
Schiedel, Matthias, McArdle, Darius J B, Padalino, Gilda, Chan, Anthony K N, Forde-Thomas, Josephine, McDonough, Michael, Whiteland, Helen, Beckmann, Manfred, Cookson, Rosa, Hoffmann, Karl F, Conway, Stuart J
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Simeprevir Potently Suppresses SARS-CoV‑2 Replication and Synergizes with Remdesivir
Lo, Ho Sing, Hui, Kenrie Pui Yan, Lai, Hei-Ming, He, Xu, Khan, Khadija Shahed, Kaur, Simranjeet, Huang, Junzhe, Li, Zhongqi, Chan, Anthony K. N, Cheung, Hayley Hei-Yin, Ng, Ka-Chun, Ho, John Chi Wang, Chen, Yu Wai, Ma, Bowen, Cheung, Peter Man-Hin, Shin, Donghyuk, Wang, Kaidao, Lee, Meng-Hsuan, Selisko, Barbara, Eydoux, Cecilia, Guillemot, Jean-Claude, Canard, Bruno, Wu, Kuen-Phon, Liang, Po-Huang, Dikic, Ivan, Zuo, Zhong, Chan, Francis K. L, Hui, David S. C, Mok, Vincent C. T, Wong, Kam-Bo, Mok, Chris Ka Pun, Ko, Ho, Aik, Wei Shen, Chan, Michael Chi Wai, Ng, Wai-Lung
Published in ACS central science (26.05.2021)
Published in ACS central science (26.05.2021)
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ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner
Xu, Xiaobao, Chan, Anthony K N, Li, Mingli, Liu, Qiao, Mattson, Nicole, Pangeni Pokharel, Sheela, Chang, Wen-Han, Yuan, Yate-Ching, Wang, Jinhui, Moore, Roger E, Pirrotte, Patrick, Wu, Jun, Su, Rui, Müschen, Markus, Rosen, Steven T, Chen, Jianjun, Yang, Lu, Chen, Chun-Wei
Published in Science advances (23.12.2022)
Published in Science advances (23.12.2022)
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Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery
Chan, Anthony K N, Han, Li, Delaney, Christopher D, Wang, Xueer, Mukhaleva, Elizaveta, Li, Mingli, Yang, Lu, Pokharel, Sheela Pangeni, Mattson, Nicole, Garcia, Michelle, Wang, Bintao, Xu, Xiaobao, Zhang, Leisi, Singh, Priyanka, Elsayed, Zeinab, Chen, Renee, Kuang, Benjamin, Wang, Jinhui, Yuan, Yate-Ching, Chen, Bryan, Chan, Lai N, Rosen, Steven T, Horne, David, Müschen, Markus, Chen, Jianjun, Vaidehi, Nagarajan, Armstrong, Scott A, Su, Rui, Chen, Chun-Wei
Published in Science advances (23.02.2024)
Published in Science advances (23.02.2024)
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Generation and validation of CRISPR-engineered human natural killer cell lines for research and therapeutic applications
Kumar, Anil, Lee, Sung June, Liu, Qiao, Chan, Anthony K.N., Pokharel, Sheela Pangeni, Yu, Jianhua, Chen, Chun-Wei, Swaminathan, Srividya
Published in STAR protocols (17.12.2021)
Published in STAR protocols (17.12.2021)
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Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening
Qin, Xi, Su, Rui, Yang, Lu, Chan, Anthony K.N., Deng, Xiaolan, Qing, Ying, Klemm, Lars, Müschen, Markus, Chen, Chun-Wei David, Chen, Jianjun
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain
Brand, Michael, Clayton, James, Moroglu, Mustafa, Schiedel, Matthias, Picaud, Sarah, Bluck, Joseph P, Skwarska, Anna, Bolland, Hannah, Chan, Anthony K. N, Laurin, Corentine M. C, Scorah, Amy R, See, Larissa, Rooney, Timothy P. C, Andrews, Katrina H, Fedorov, Oleg, Perell, Gabriella, Kalra, Prakriti, Vinh, Kayla B, Cortopassi, Wilian A, Heitel, Pascal, Christensen, Kirsten E, Cooper, Richard I, Paton, Robert S, Pomerantz, William C. K, Biggin, Philip C, Hammond, Ester M, Filippakopoulos, Panagis, Conway, Stuart J
Published in Journal of medicinal chemistry (22.07.2021)
Published in Journal of medicinal chemistry (22.07.2021)
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Journal Article
Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL-Rearranged Leukemias
Chan, Anthony K.N., Delaney, Christopher D., Yang, Lu, Chang, Wen-Han, Miyashita, Kazuya, Liu, Qiao, Pokharel, Sheela Pangeni, Armstrong, Scott A., Chen, Chun-Wei David
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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