Development of a versatile oncolytic virus platform for local intra-tumoural expression of therapeutic transgenes
Marino, Nalini, Illingworth, Sam, Kodialbail, Prithvi, Patel, Ashvin, Calderon, Hugo, Lear, Rochelle, Fisher, Kerry D, Champion, Brian R, Brown, Alice C N
Published in PloS one (18.05.2017)
Published in PloS one (18.05.2017)
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Journal Article
Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples
Scott, Eleanor M., Jacobus, Egon J., Lyons, Brian, Frost, Sally, Freedman, Joshua D., Dyer, Arthur, Khalique, Hena, Taverner, William K., Carr, Alison, Champion, Brian R., Fisher, Kerry D., Seymour, Len W., Duffy, Margaret R.
Published in Journal for immunotherapy of cancer (21.11.2019)
Published in Journal for immunotherapy of cancer (21.11.2019)
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Journal Article
External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase
Pokrovska, Tzveta D, Jacobus, Egon J, Puliyadi, Rathi, Prevo, Remko, Frost, Sally, Dyer, Arthur, Baugh, Richard, Rodriguez-Berriguete, Gonzalo, Fisher, Kerry, Granata, Giovanna, Herbert, Katharine, Taverner, William K, Champion, Brian R, Higgins, Geoff S, Seymour, Len W, Lei-Rossmann, Janet
Published in Cancers (26.03.2020)
Published in Cancers (26.03.2020)
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Journal Article
Localization of the Delta-like-1-binding Site in Human Notch-1 and Its Modulation by Calcium Affinity
Cordle, Jemima, RedfieldZ, Christina, Stacey, Martin, van der Merwe, P. Anton, Willis, Antony C., Champion, Brian R., Hambleton, Sophie, Handford, Penny A.
Published in The Journal of biological chemistry (25.04.2008)
Published in The Journal of biological chemistry (25.04.2008)
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Journal Article
An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
Freedman, Joshua D, Duffy, Margaret R, Lei-Rossmann, Janet, Muntzer, Alice, Scott, Eleanor M, Hagel, Joachim, Campo, Leticia, Bryant, Richard J, Verrill, Clare, Lambert, Adam, Miller, Paul, Champion, Brian R, Seymour, Leonard W, Fisher, Kerry D
Published in Cancer research (Chicago, Ill.) (15.12.2018)
Published in Cancer research (Chicago, Ill.) (15.12.2018)
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Journal Article
Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism
Wong, Kenneth K, Carpenter, Matthew J, Young, Lesley L, Walker, Susan J, McKenzie, Grahame, Rust, Alyson J, Ward, George, Packwood, Laura, Wahl, Karen, Delriviere, Luc, Hoyne, Gerard, Gibbs, Paul, Champion, Brian R, Lamb, Jonathan R, Dallman, Margaret J
Published in The Journal of clinical investigation (01.12.2003)
Published in The Journal of clinical investigation (01.12.2003)
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Journal Article
Abstract 4875: Developing tumor-localized, combination immunotherapies
Champion, Brian R., Rasiah, Nalini, Illingworth, Sam, Besneux, Matthieu, Lear, Rochelle, Plumb, Darren, Kodialbail, Prithvi, Brown, Alice C.N.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Small Interfering RNA-Mediated Knockdown of Notch Ligands in Primary CD4+ T Cells and Dendritic Cells Enhances Cytokine Production
Stallwood, Yvette, Briend, Emmanuel, Ray, Katrina M, Ward, George A, Smith, Beverley J, Nye, Emma, Champion, Brian R, McKenzie, Grahame J
Published in The Journal of immunology (1950) (15.07.2006)
Published in The Journal of immunology (1950) (15.07.2006)
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Journal Article
Immunogenicity of a peptide‐based anti‐IgE conjugate vaccine in non‐human primates
Weeratna, Risini D., Chikh, Ghania, Zhang, Lu, Fraser, James D., Thorn, Jennifer M., Merson, James R., McCluskie, Michael J., Champion, Brian R., Davis, Heather L.
Published in Immunity, Inflammation and Disease (01.06.2016)
Published in Immunity, Inflammation and Disease (01.06.2016)
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Journal Article
Identification and characterization of SKAT‐2, a novel Th2‐specific zinc finger gene
Blanchard, Andy D., Page, Kevin R., Watkin, Harriet, Hayward, Penny, Wong, Tony, Bartholomew, Michelle, Quint, Diana J., Daly, Maria, Garcia‐Lopez, Jorge, Champion, Brian R.
Published in European journal of immunology (01.11.2000)
Published in European journal of immunology (01.11.2000)
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Journal Article
RFP represses transcriptional activation by bHLH transcription factors
BLOOR, Adrian J. C, KOTSOPOULOU, Ekaterina, HAYWARD, Penny, CHAMPION, Brian R, GREEN, Anthony R
Published in Oncogene (13.10.2005)
Published in Oncogene (13.10.2005)
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Journal Article
Notch: a unique therapeutic target for immunomodulation
McKenzie, Grahame J, Khan, Mamnunur, Briend, Emmanuel, Stallwood, Yvette, Champion, Brian R
Published in Expert opinion on therapeutic targets (01.04.2005)
Published in Expert opinion on therapeutic targets (01.04.2005)
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Journal Article
Abstract 1582: T-SIGn cancer gene therapy and anti-EGFR CAR-T cells synergize in combination therapy to clear A549 lung tumor xenografts and lung metastases in NSG mice
Sonzogni, Olmo, Zak, Daniel, West, Katy, Lear, Rochelle, Muntzer, Alice, Champion, Brian R., Rottman, James B.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 1710: A T-SIGn cancer gene therapy virus expressing an EpCAM-targeted bispecific T-cell activator stimulates T-cells and induces tumor cell death in patient-derived organotypic non-small cell lung cancer (NSCLC) spheroids ex vivo
Noureddine, Moataz, West, Katy, Isaacson, Elizabeth, Alarcon, Sylvia, Lathan, Christopher S., Wain, John, Barbie, David A., Paweletz, Cloud P., Ivanova, Elena, Champion, Brian R.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 5098: NG-348: a novel oncolytic virus designed to mediate anti-tumour activity via the potent and selective polyclonal activation of tumor-infiltrating T-cells
Champion, Brian R., Besneux, Matthieu, Marino, Nalini, Plumb, Darren, Kodialbail, Prithvi, Illingworth, Sam, Lear, Rochelle, Brown, Alice C.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 5013: NG-641: An oncolytic T-SIGn virus targeting cancer-associated fibroblasts in the stromal microenvironment of human carcinomas
Champion, Brian R., Besneux, Matthieu, Patsalidou, Marilena, Silva, Ana, Zonca, Manuela, Marino, Nalini, Genova, Gianfranco di, Illingworth, Sam, Fedele, Stefania, Slater, Lorna, Lilley, Fred, Plumb, Darren, West, Katy, Cockle, Paul, Brown, Alice
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 295: Delivery of checkpoint inhibitor antibodies and other therapeutics directly to tumors by encoding them within the oncolytic adenovirus enadenotucirev
Champion, Brian R., Kodialbail, Prithvi, Illingworth, Sam, Rasiah, Nalini, Cochrane, Daniel, Beadle, John, Fisher, Kerry, Brown, Alice
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 5746: Flexible tumor-specific cytokine and antigen delivery through the T-SIGn vector platform enables effective CAR-T cell therapy against solid tumors
Sasso, Maria Stella, Bergin, Rachel, Lear, Rochelle, Plumb, Darren, Zonca, Manuela, Vainiute, Eva, Snowden, Meg, Jang, Tae Hyun, Muntzer, Alice, Cerqueira, Carla C., West, Katy, Bucktrout, Samantha, Champion, Brian R.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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