An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
Freedman, Joshua D, Duffy, Margaret R, Lei-Rossmann, Janet, Muntzer, Alice, Scott, Eleanor M, Hagel, Joachim, Campo, Leticia, Bryant, Richard J, Verrill, Clare, Lambert, Adam, Miller, Paul, Champion, Brian R, Seymour, Leonard W, Fisher, Kerry D
Published in Cancer research (Chicago, Ill.) (15.12.2018)
Published in Cancer research (Chicago, Ill.) (15.12.2018)
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Development of a versatile oncolytic virus platform for local intra-tumoural expression of therapeutic transgenes
Marino, Nalini, Illingworth, Sam, Kodialbail, Prithvi, Patel, Ashvin, Calderon, Hugo, Lear, Rochelle, Fisher, Kerry D, Champion, Brian R, Brown, Alice C N
Published in PloS one (18.05.2017)
Published in PloS one (18.05.2017)
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Phase 1 study of intravenous administration of the chimeric adenovirus enadenotucirev in patients undergoing primary tumor resection
Garcia-Carbonero, Rocio, Salazar, Ramon, Duran, Ignacio, Osman-Garcia, Ignacio, Paz-Ares, Luis, Bozada, Juan M, Boni, Valentina, Blanc, Christine, Seymour, Len, Beadle, John, Alvis, Simon, Champion, Brian, Calvo, Emiliano, Fisher, Kerry
Published in Journal for immunotherapy of cancer (19.09.2017)
Published in Journal for immunotherapy of cancer (19.09.2017)
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Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples
Scott, Eleanor M., Jacobus, Egon J., Lyons, Brian, Frost, Sally, Freedman, Joshua D., Dyer, Arthur, Khalique, Hena, Taverner, William K., Carr, Alison, Champion, Brian R., Fisher, Kerry D., Seymour, Len W., Duffy, Margaret R.
Published in Journal for immunotherapy of cancer (21.11.2019)
Published in Journal for immunotherapy of cancer (21.11.2019)
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External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase
Pokrovska, Tzveta D, Jacobus, Egon J, Puliyadi, Rathi, Prevo, Remko, Frost, Sally, Dyer, Arthur, Baugh, Richard, Rodriguez-Berriguete, Gonzalo, Fisher, Kerry, Granata, Giovanna, Herbert, Katharine, Taverner, William K, Champion, Brian R, Higgins, Geoff S, Seymour, Len W, Lei-Rossmann, Janet
Published in Cancers (26.03.2020)
Published in Cancers (26.03.2020)
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Localization of the Delta-like-1-binding Site in Human Notch-1 and Its Modulation by Calcium Affinity
Cordle, Jemima, RedfieldZ, Christina, Stacey, Martin, van der Merwe, P. Anton, Willis, Antony C., Champion, Brian R., Hambleton, Sophie, Handford, Penny A.
Published in The Journal of biological chemistry (25.04.2008)
Published in The Journal of biological chemistry (25.04.2008)
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Abstract 4875: Developing tumor-localized, combination immunotherapies
Champion, Brian R., Rasiah, Nalini, Illingworth, Sam, Besneux, Matthieu, Lear, Rochelle, Plumb, Darren, Kodialbail, Prithvi, Brown, Alice C.N.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus
Illingworth, Sam, Di, Ying, Bauzon, Maxine, Lei, Janet, Duffy, Margaret R., Alvis, Simon, Champion, Brian, Lieber, André, Hermiston, Terry, Seymour, Len W., Beadle, John, Fisher, Kerry
Published in Molecular therapy. Oncolytics (16.06.2017)
Published in Molecular therapy. Oncolytics (16.06.2017)
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Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators
Dyer, Arthur, Di, Ying, Calderon, Hugo, Illingworth, Sam, Kueberuwa, Gray, Tedcastle, Alison, Jakeman, Phil, Chia, Suet Lin, Brown, Alice, Silva, Michael A., Barlow, David, Beadle, John, Hermiston, Terry, Ferguson, David J.P., Champion, Brian, Fisher, Kerry D., Seymour, Leonard W.
Published in Molecular therapy. Oncolytics (17.03.2017)
Published in Molecular therapy. Oncolytics (17.03.2017)
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Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα Activation
Taverner, William K., Jacobus, Egon J., Christianson, John, Champion, Brian, Paton, Adrienne W., Paton, James C., Su, Weiheng, Cawood, Ryan, Seymour, Len W., Lei-Rossmann, Janet
Published in Molecular therapy. Oncolytics (20.12.2019)
Published in Molecular therapy. Oncolytics (20.12.2019)
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A Phase 1 First-in-Human Study (B4901001) Evaluating a Novel Anti-IgE Vaccine in Adult Subjects with Allergic Rhinitis
Wong, Gilbert Y., MD, Elfassi, Emile, MD, Girard, Ginette, MD, Yang, William H., MD, Hebert, Jacques, MD, Bugarini, Roberto, PhD, O'Connell, Michael A., MD, Champion, Brian, PhD, Merson, James, PhD, Davis, Heather, PhD
Published in Journal of allergy and clinical immunology (01.02.2016)
Published in Journal of allergy and clinical immunology (01.02.2016)
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Expression of human CD46 and trans-complementation by murine adenovirus 1 fails to allow productive infection by a group B oncolytic adenovirus in murine cancer cells
Lei, Janet, Jacobus, Egon J, Taverner, William K, Fisher, Kerry D, Hemmi, Silvio, West, Katy, Slater, Lorna, Lilley, Fred, Brown, Alice, Champion, Brian, Duffy, Margaret R, Seymour, Len W
Published in Journal for immunotherapy of cancer (13.06.2018)
Published in Journal for immunotherapy of cancer (13.06.2018)
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Journal Article
Anti-IgE Qb-VLP Conjugate Vaccine Self-Adjuvants through Activation of TLR7
Akache, Bassel, Weeratna, Risini D, Deora, Aparna, Thorn, Jennifer M, Champion, Brian, Merson, James R, Davis, Heather L, McCluskie, Michael J
Published in Vaccines (Basel) (21.01.2016)
Published in Vaccines (Basel) (21.01.2016)
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Journal Article
Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism
Wong, Kenneth K, Carpenter, Matthew J, Young, Lesley L, Walker, Susan J, McKenzie, Grahame, Rust, Alyson J, Ward, George, Packwood, Laura, Wahl, Karen, Delriviere, Luc, Hoyne, Gerard, Gibbs, Paul, Champion, Brian R, Lamb, Jonathan R, Dallman, Margaret J
Published in The Journal of clinical investigation (01.12.2003)
Published in The Journal of clinical investigation (01.12.2003)
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Small Interfering RNA-Mediated Knockdown of Notch Ligands in Primary CD4+ T Cells and Dendritic Cells Enhances Cytokine Production
Stallwood, Yvette, Briend, Emmanuel, Ray, Katrina M, Ward, George A, Smith, Beverley J, Nye, Emma, Champion, Brian R, McKenzie, Grahame J
Published in The Journal of immunology (1950) (15.07.2006)
Published in The Journal of immunology (1950) (15.07.2006)
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Immunogenicity of a peptide‐based anti‐IgE conjugate vaccine in non‐human primates
Weeratna, Risini D., Chikh, Ghania, Zhang, Lu, Fraser, James D., Thorn, Jennifer M., Merson, James R., McCluskie, Michael J., Champion, Brian R., Davis, Heather L.
Published in Immunity, Inflammation and Disease (01.06.2016)
Published in Immunity, Inflammation and Disease (01.06.2016)
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"Arming" the chimeric oncolytic adenovirus enadenotucirev to deliver checkpoint inhibitors and other therapeutics directly to tumours
Champion, Brian R, Kodialbail, Prithvi, Illingworth, Sam, Rasiah, Nalini, Cochrane, Dan, Beadle, John, Fisher, Kerry, Brown, Alice CN
Published in Journal for immunotherapy of cancer (06.11.2014)
Published in Journal for immunotherapy of cancer (06.11.2014)
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RFP represses transcriptional activation by bHLH transcription factors
BLOOR, Adrian J. C, KOTSOPOULOU, Ekaterina, HAYWARD, Penny, CHAMPION, Brian R, GREEN, Anthony R
Published in Oncogene (13.10.2005)
Published in Oncogene (13.10.2005)
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