The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging
Angeli, Suzanne, Foulger, Anna, Chamoli, Manish, Peiris, Tanuja Harshani, Gerencser, Akos, Shahmirzadi, Azar Asadi, Andersen, Julie, Lithgow, Gordon
Published in eLife (01.09.2021)
Published in eLife (01.09.2021)
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Journal Article
Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis
Matai, Latika, Sarkar, Gautam Chandra, Chamoli, Manish, Malik, Yasir, Kumar, Shashi Shekhar, Rautela, Umanshi, Jana, Nihar Ranjan, Chakraborty, Kausik, Mukhopadhyay, Arnab
Published in Proceedings of the National Academy of Sciences - PNAS (27.08.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (27.08.2019)
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Journal Article
Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function
Anand, Nikhita, Holcom, Angelina, Broussalian, Michael, Schmidt, Minna, Chinta, Shankar J., Lithgow, Gordon J., Andersen, Julie K., Chamoli, Manish
Published in Neurobiology of disease (01.06.2020)
Published in Neurobiology of disease (01.06.2020)
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Journal Article
Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction
Chamoli, Manish, Goyala, Anita, Tabrez, Syed Shamsh, Siddiqui, Atif Ahmed, Singh, Anupama, Antebi, Adam, Lithgow, Gordon J., Watts, Jennifer L., Mukhopadhyay, Arnab
Published in Nature communications (25.09.2020)
Published in Nature communications (25.09.2020)
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Journal Article
Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans
Muthaiyan Shanmugam, Muniesh, Chaudhuri, Jyotiska, Sellegounder, Durai, Sahu, Amit Kumar, Guha, Sanjib, Chamoli, Manish, Hodge, Brian, Bose, Neelanjan, Roberts, Charis, Farrera, Dominique O, Lithgow, Gordon, Sarpong, Richmond, Galligan, James J, Kapahi, Pankaj
Published in eLife (20.09.2023)
Published in eLife (20.09.2023)
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Journal Article
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
Lucanic, Mark, Plummer, W Todd, Chen, Esteban, Harke, Jailynn, Foulger, Anna C, Onken, Brian, Coleman-Hulbert, Anna L, Dumas, Kathleen J, Guo, Suzhen, Johnson, Erik, Bhaumik, Dipa, Xue, Jian, Crist, Anna B, Presley, Michael P, Harinath, Girish, Sedore, Christine A, Chamoli, Manish, Kamat, Shaunak, Chen, Michelle K, Angeli, Suzanne, Chang, Christina, Willis, John H, Edgar, Daniel, Royal, Mary Anne, Chao, Elizabeth A, Patel, Shobhna, Garrett, Theo, Ibanez-Ventoso, Carolina, Hope, June, Kish, Jason L, Guo, Max, Lithgow, Gordon J, Driscoll, Monica, Phillips, Patrick C
Published in Nature communications (21.02.2017)
Published in Nature communications (21.02.2017)
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Journal Article
Amyloid β accelerates age-related proteome-wide protein insolubility
Anderton, Edward, Chamoli, Manish, Bhaumik, Dipa, King, Christina D., Xie, Xueshu, Foulger, Anna, Andersen, Julie K., Schilling, Birgit, Lithgow, Gordon J.
Published in GeroScience (16.05.2024)
Published in GeroScience (16.05.2024)
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Journal Article
Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity
Arputhasamy, Cyrene, Foulger, Anna C., Lucanic, Mark, Rane, Anand, Schmidt, Minna, Garrett, Theo, Broussalian, Michael, Battistoni, Elena, Brem, Rachel B., Lithgow, Gordon J., Chamoli, Manish, Andersen, Julie K.
Published in GeroScience (01.04.2023)
Published in GeroScience (01.04.2023)
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Journal Article
Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes
Banse, Stephen A., Sedore, Christine A., Johnson, Erik, Coleman-Hulbert, Anna L., Onken, Brian, Hall, David, Jackson, E. Grace, Huynh, Phu, Foulger, Anna C., Guo, Suzhen, Garrett, Theo, Xue, Jian, Inman, Delaney, Morshead, Mackenzie L., Plummer, W. Todd, Chen, Esteban, Bhaumik, Dipa, Chen, Michelle K., Harinath, Girish, Chamoli, Manish, Quinn, Rose P., Falkowski, Ron, Edgar, Daniel, Schmidt, Madeline O., Lucanic, Mark, Guo, Max, Driscoll, Monica, Lithgow, Gordon J., Phillips, Patrick C.
Published in GeroScience (01.04.2024)
Published in GeroScience (01.04.2024)
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Journal Article
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy
Tezil, Tugsan, Chamoli, Manish, Ng, Che-Ping, Simon, Roman P, Butler, Victoria J, Jung, Manfred, Andersen, Julie, Kao, Aimee W, Verdin, Eric
Published in npj aging and mechanisms of disease (02.10.2019)
Published in npj aging and mechanisms of disease (02.10.2019)
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Journal Article
A novel kinase regulates dietary restriction‐mediated longevity in Caenorhabditis elegans
Chamoli, Manish, Singh, Anupama, Malik, Yasir, Mukhopadhyay, Arnab
Published in Aging cell (01.08.2014)
Published in Aging cell (01.08.2014)
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Journal Article
DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16
Sarkar, Gautam Chandra, Rautela, Umanshi, Goyala, Anita, Datta, Sudeshna, Anand, Nikhita, Singh, Anupama, Singh, Prachi, Chamoli, Manish, Mukhopadhyay, Arnab
Published in Development (Cambridge) (01.09.2023)
Published in Development (Cambridge) (01.09.2023)
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Journal Article
Taurine deficiency as a driver of aging
Singh, Parminder, Gollapalli, Kishore, Mangiola, Stefano, Schranner, Daniela, Yusuf, Mohd Aslam, Chamoli, Manish, Shi, Sting L, Lopes Bastos, Bruno, Nair, Tripti, Riermeier, Annett, Vayndorf, Elena M, Wu, Judy Z, Nilakhe, Aishwarya, Nguyen, Christina Q, Muir, Michael, Kiflezghi, Michael G, Foulger, Anna, Junker, Alex, Devine, Jack, Sharan, Kunal, Chinta, Shankar J, Rajput, Swati, Rane, Anand, Baumert, Philipp, Schönfelder, Martin, Iavarone, Francescopaolo, di Lorenzo, Giorgia, Kumari, Swati, Gupta, Alka, Sarkar, Rajesh, Khyriem, Costerwell, Chawla, Amanpreet S, Sharma, Ankur, Sarper, Nazan, Chattopadhyay, Naibedya, Biswal, Bichitra K, Settembre, Carmine, Nagarajan, Perumal, Targoff, Kimara L, Picard, Martin, Gupta, Sarika, Velagapudi, Vidya, Papenfuss, Anthony T, Kaya, Alaattin, Ferreira, Miguel Godinho, Kennedy, Brian K, Andersen, Julie K, Lithgow, Gordon J, Ali, Abdullah Mahmood, Mukhopadhyay, Arnab, Palotie, Aarno, Kastenmüller, Gabi, Kaeberlein, Matt, Wackerhage, Henning, Pal, Bhupinder, Yadav, Vijay K
Published in Science (American Association for the Advancement of Science) (09.06.2023)
Published in Science (American Association for the Advancement of Science) (09.06.2023)
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Journal Article
Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment
Nambiar, Dhanya K, Viswanathan, Vignesh, Cao, Hongbin, Zhang, Weiruo, Guan, Li, Chamoli, Manish, Holmes, Brittany, Kong, Christina, Hildebrand, Rachel, Koong, Amanda Jeanette, von Eyben, Rie, Plevritis, Sylvia, Li, Lingyin, Giaccia, Amato, Engleman, Edgar, Le, Quynh Thu
Published in Cancer research (Chicago, Ill.) (02.10.2023)
Published in Cancer research (Chicago, Ill.) (02.10.2023)
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Journal Article
A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification
Chaudhuri, Jyotiska, Bose, Neelanjan, Gong, Jianke, Hall, David, Rifkind, Alexander, Bhaumik, Dipa, Peiris, T. Harshani, Chamoli, Manish, Le, Catherine H., Liu, Jianfeng, Lithgow, Gordon J., Ramanathan, Arvind, Xu, X.Z. Shawn, Kapahi, Pankaj
Published in Current biology (21.11.2016)
Published in Current biology (21.11.2016)
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Journal Article
Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra‐3/daf‐11 signaling in Caenorhabditis elegans
Khanna, Amit, Sellegounder, Durai, Kumar, Jitendra, Chamoli, Manish, Vargas, Miguel, Chinta, Shankar J., Rane, Anand, Nelson, Christopher, Peiris, T. Harshani, Brem, Rachel, Andersen, Julie, Lithgow, Gordon, Kapahi, Pankaj
Published in Aging cell (01.05.2021)
Published in Aging cell (01.05.2021)
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Journal Article