Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties
Kalčic, Filip, Zgarbová, Michala, Hodek, Jan, Chalupský, Karel, Dračínský, Martin, Dvořáková, Alexandra, Strmeň, Timotej, Šebestík, Jaroslav, Baszczyňski, Ondřej, Weber, Jan, Mertlíková-Kaiserová, Helena, Janeba, Zlatko
Published in Journal of medicinal chemistry (25.11.2021)
Published in Journal of medicinal chemistry (25.11.2021)
Get full text
Journal Article
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2‑a]pyridine Structure
Mejdrová, Ivana, Dušek, Jan, Škach, Kryštof, Stefela, Alžbeta, Skoda, Josef, Chalupský, Karel, Dohnalová, Klára, Pavkova, Ivona, Kronenberger, Thales, Rashidian, Azam, Smutná, Lucie, Duchoslav, Vojtěch, Smutny, Tomas, Pávek, Petr, Nencka, Radim
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
Get full text
Journal Article
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2‑b]pyridazine Derivatives Identified by Scaffold Hopping
Břehová, Petra, Řezníčková, Eva, Škach, Kryštof, Jorda, Radek, Dejmek, Milan, Vojáčková, Veronika, Šála, Michal, Kovalová, Markéta, Dračínský, Martin, Dolníková, Alexandra, Strmeň, Timotej, Kinnertová, Monika, Chalupský, Karel, Dvořáková, Alexandra, Gucký, Tomáš, Mertlíková Kaiserová, Helena, Klener, Pavel, Nencka, Radim, Kryštof, Vladimír
Published in Journal of medicinal chemistry (24.08.2023)
Published in Journal of medicinal chemistry (24.08.2023)
Get full text
Journal Article
Triazinium Ligation: Bioorthogonal Reaction of N1‐Alkyl 1,2,4‐Triazinium Salts
Šlachtová, Veronika, Bellová, Simona, La‐Venia, Agustina, Galeta, Juraj, Dračínský, Martin, Chalupský, Karel, Dvořáková, Alexandra, Mertlíková‐Kaiserová, Helena, Rukovanský, Peter, Dzijak, Rastislav, Vrabel, Milan
Published in Angewandte Chemie International Edition (04.09.2023)
Published in Angewandte Chemie International Edition (04.09.2023)
Get full text
Journal Article
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
Skácel, Jan, Djukic, Stefan, Baszczyňski, Ondřej, Kalčic, Filip, Bílek, Tadeáš, Chalupský, Karel, Kozák, Jaroslav, Dvořáková, Alexandra, Tloušt’ová, Eva, Král’ová, Zuzana, Šmídková, Markéta, Voldřich, Jan, Rumlová, Michaela, Pachl, Petr, Brynda, Jiří, Vučková, Tereza, Fábry, Milan, Snášel, Jan, Pichová, Iva, Řezáčová, Pavlína, Mertlíková-Kaiserová, Helena, Janeba, Zlatko
Published in Journal of medicinal chemistry (25.05.2023)
Published in Journal of medicinal chemistry (25.05.2023)
Get full text
Journal Article
Simultaneous detection of chicken cytokines in plasma samples using the Bio-Plex assay
Mucksová, Jitka, Chalupský, Karel, Plachý, Jiří, Kalina, Jiří, Rachačová, Pavla, Staněk, Ondřej, Trefil, Pavel
Published in Poultry science (01.04.2018)
Published in Poultry science (01.04.2018)
Get full text
Journal Article
Simvastatin and dehydroepiandrosterone sulfate effects against hypoxic pulmonary hypertension are not additive
Krása, K, Vajnerova, O, D Uris Ova, J, Minaříkova, M, Miková, D, Srbová, M, Chalupský, K, Kaftanová, B, Hampl, V
Published in Physiological research (16.12.2022)
Published in Physiological research (16.12.2022)
Get full text
Journal Article
Rational Design of Highly Potent SARS-CoV‑2 nsp14 Methyltransferase Inhibitors
Štefek, Milan, Chalupská, Dominika, Chalupský, Karel, Zgarbová, Michala, Dvořáková, Alexandra, Krafčíková, Petra, Li, Alice Shi Ming, Šála, Michal, Dejmek, Milan, Otava, Tomáš, Chaloupecká, Ema, Kozák, Jaroslav, Kozic, Ján, Vedadi, Masoud, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim
Published in ACS omega (01.08.2023)
Published in ACS omega (01.08.2023)
Get full text
Journal Article
Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides
Kocek, Hugo, Chalupská, Dominika, Dejmek, Milan, Dvořáková, Alexandra, Zgarbová, Michala, Šála, Michal, Chalupský, Karel, Krafčíková, Petra, Otava, Tomáš, Drexler, Matúš, Procházková, Eliška, Klepetářová, Blanka, Štefek, Milan, Kozic, Ján, Mertlíková-Kaiserová, Helena, Boura, Evzen, Weber, Jan, Nencka, Radim
Published in RSC medicinal chemistry (01.08.2024)
Published in RSC medicinal chemistry (01.08.2024)
Get full text
Journal Article
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase
Silhan, Jan, Klima, Martin, Otava, Tomas, Skvara, Petr, Chalupska, Dominika, Chalupsky, Karel, Kozic, Jan, Nencka, Radim, Boura, Evzen
Published in Nature communications (20.04.2023)
Published in Nature communications (20.04.2023)
Get full text
Journal Article
Endothelial Dihydrofolate Reductase: Critical for Nitric Oxide Bioavailability and Role in Angiotensin II Uncoupling of Endothelial Nitric Oxide Synthase
Chalupsky, Karel, Cai, Hua, Moncada, Salvador
Published in Proceedings of the National Academy of Sciences - PNAS (21.06.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (21.06.2005)
Get full text
Journal Article
Vasorelaxant activity of some oxime derivatives
Jaroš, Filip, Straka, Tomáš, Dobešová, Zdenka, Pintérová, Mária, Chalupský, Karel, Kuneš, Jaroslav, Entlicher, Gustav, Zicha, Josef
Published in European journal of pharmacology (01.12.2007)
Published in European journal of pharmacology (01.12.2007)
Get full text
Journal Article
KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype
Kasparek, Petr, Ileninova, Zuzana, Zbodakova, Olga, Kanchev, Ivan, Benada, Oldrich, Chalupsky, Karel, Brattsand, Maria, Beck, Inken M, Sedlacek, Radislav
Published in PLoS genetics (01.01.2017)
Published in PLoS genetics (01.01.2017)
Get full text
Journal Article
Plectin controls biliary tree architecture and stability in cholestasis
Jirouskova, Marketa, Nepomucka, Katerina, Oyman-Eyrilmez, Gizem, Kalendova, Alzbeta, Havelkova, Helena, Sarnova, Lenka, Chalupsky, Karel, Schuster, Bjoern, Benada, Oldrich, Miksatkova, Petra, Kuchar, Martin, Fabian, Ondrej, Sedlacek, Radislav, Wiche, Gerhard, Gregor, Martin
Published in Journal of hepatology (01.05.2018)
Published in Journal of hepatology (01.05.2018)
Get full text
Journal Article
Localization of SARS-CoV-2 Capping Enzymes Revealed by an Antibody against the nsp10 Subunit
Horova, Vladimira, Landova, Barbora, Hodek, Jan, Chalupsky, Karel, Krafcikova, Petra, Chalupska, Dominika, Duchoslav, Vojtech, Weber, Jan, Boura, Evzen, Klima, Martin
Published in Viruses (29.07.2021)
Published in Viruses (29.07.2021)
Get full text
Journal Article
NADPH oxidases and HIF1 promote cardiac dysfunction and pulmonary hypertension in response to glucocorticoid excess
Kračun, Damir, Klop, Mathieu, Knirsch, Anna, Petry, Andreas, Kanchev, Ivan, Chalupsky, Karel, Wolf, Cordula M., Görlach, Agnes
Published in Redox biology (01.07.2020)
Published in Redox biology (01.07.2020)
Get full text
Journal Article
Sulfonothioated meso-Methyl BODIPY Shows Enhanced Uncaging Efficiency and Releases H2Sn
Wohlrábová, Lucie, Okoročenkova, Jana, Palao, Eduardo, Kužmová, Erika, Chalupský, Karel, Klán, Petr, Slanina, Tomáš
Published in Organic letters (15.09.2023)
Published in Organic letters (15.09.2023)
Get full text
Journal Article
Sulfonothioated meso -Methyl BODIPY Shows Enhanced Uncaging Efficiency and Releases H 2 S n
Wohlrábová, Lucie, Okoročenkova, Jana, Palao, Eduardo, Kužmová, Erika, Chalupský, Karel, Klán, Petr, Slanina, Tomáš
Published in Organic letters (15.09.2023)
Published in Organic letters (15.09.2023)
Get full text
Journal Article