Mining microbial genomes for new natural products and biosynthetic pathways
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Strategies for the Discovery of New Natural Products by Genome Mining
Zerikly, Malek, Challis, Gregory L
Published in Chembiochem : a European journal of chemical biology (02.03.2009)
Published in Chembiochem : a European journal of chemical biology (02.03.2009)
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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
Laureti, Luisa, Song, Lijiang, Huang, Sheng, Corre, Christophe, Leblond, Pierre, Challis, Gregory L, Aigle, Bertrand
Published in Proceedings of the National Academy of Sciences - PNAS (12.04.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (12.04.2011)
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Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate
Louka, Savvas, Barry, Sarah M, Heyes, Derren J, Mubarak, M. Qadri E, Ali, Hafiz Saqib, Alkhalaf, Lona M, Munro, Andrew W, Scrutton, Nigel S, Challis, Gregory L, de Visser, Sam P
Published in Journal of the American Chemical Society (16.09.2020)
Published in Journal of the American Chemical Society (16.09.2020)
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Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
Izoré, Thierry, Candace Ho, Y T, Kaczmarski, Joe A, Gavriilidou, Athina, Chow, Ka Ho, Steer, David L, Goode, Robert J A, Schittenhelm, Ralf B, Tailhades, Julien, Tosin, Manuela, Challis, Gregory L, Krenske, Elizabeth H, Ziemert, Nadine, Jackson, Colin J, Cryle, Max J
Published in Nature communications (04.05.2021)
Published in Nature communications (04.05.2021)
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Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis
Huang, Chuan, Zabala, Daniel, de Los Santos, Emmanuel L C, Song, Lijiang, Corre, Christophe, Alkhalaf, Lona M, Challis, Gregory L
Published in Nucleic acids research (22.02.2023)
Published in Nucleic acids research (22.02.2023)
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A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis
Masschelein, Joleen, Sydor, Paulina K, Hobson, Christian, Howe, Rhiannon, Jones, Cerith, Roberts, Douglas M, Ling Yap, Zhong, Parkhill, Julian, Mahenthiralingam, Eshwar, Challis, Gregory L
Published in Nature chemistry (01.10.2019)
Published in Nature chemistry (01.10.2019)
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Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC
Alkhalaf, Lona M, Barry, Sarah M, Rea, Dean, Gallo, Angelo, Griffiths, Daniel, Lewandowski, Józef R, Fulop, Vilmos, Challis, Gregory L
Published in Journal of the American Chemical Society (09.01.2019)
Published in Journal of the American Chemical Society (09.01.2019)
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Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism
Nakou, Ioanna T., Jenner, Matthew, Dashti, Yousef, Romero‐Canelón, Isolda, Masschelein, Joleen, Mahenthiralingam, Eshwar, Challis, Gregory L.
Published in Angewandte Chemie International Edition (14.12.2020)
Published in Angewandte Chemie International Edition (14.12.2020)
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Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis
Barry, Sarah M, Kers, Johan A, Johnson, Evan G, Song, Lijiang, Aston, Philip R, Patel, Bhumit, Krasnoff, Stuart B, Crane, Brian R, Gibson, Donna M, Loria, Rosemary, Challis, Gregory L
Published in Nature chemical biology (01.10.2012)
Published in Nature chemical biology (01.10.2012)
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Antimalarial Activity of Natural and Synthetic Prodiginines
Papireddy, Kancharla, Smilkstein, Martin, Kelly, Jane Xu, Shweta, Salem, Shaimaa M, Alhamadsheh, Mamoun, Haynes, Stuart W, Challis, Gregory L, Reynolds, Kevin A
Published in Journal of medicinal chemistry (11.08.2011)
Published in Journal of medicinal chemistry (11.08.2011)
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