Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens
Scarff, Jennifer M., Waidyarachchi, Samanthi L., Meyer, Christopher J., Lane, Douglas J., Chai, Weirui, Lemmon, Margaret M., Liu, Jiuyu, Butler, Michelle M., Bowlin, Terry L., Lee, Richard E., Panchal, Rekha G.
Published in Journal of antibiotics (01.09.2019)
Published in Journal of antibiotics (01.09.2019)
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C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation
Stewart, Nichole K, Toth, Marta, Alqurafi, Maha A, Chai, Weirui, Nguyen, Thu Q, Quan, Pojun, Lee, Mijoon, Buynak, John D, Smith, Clyde A, Vakulenko, Sergei B
Published in mBio (14.04.2022)
Published in mBio (14.04.2022)
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Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3
Papp-Wallace, Krisztina M, Senkfor, Baui, Gatta, Julian, Chai, Weirui, Taracila, Magdalena A, Shanmugasundaram, Veerabahu, Han, Seungil, Zaniewski, Richard P, Lacey, Brian M, Tomaras, Andrew P, Skalweit, Marion J, Harris, Michael E, Rice, Louis B, Buynak, John D, Bonomo, Robert A
Published in Antimicrobial Agents and Chemotherapy (01.11.2012)
Published in Antimicrobial Agents and Chemotherapy (01.11.2012)
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Triethysilyl enol ethers in the synthesis of carbapenem precursors
Nguyen, Thu Q., Chai, Weirui, Gu, Jane, Cook, Katie, Kim, Eugene, Goetz, Sam, Farni, Zach, Chepuru, Monica, Cox, Melina, Nguyen, Pauline, Raja, Hashim, Magistrado, Patrick, Michael, Faith, Oelschlaeger, Peter, Buynak, John D.
Published in Tetrahedron letters (03.06.2015)
Published in Tetrahedron letters (03.06.2015)
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Journal Article
Aminomethyl Spectinomycins as Therapeutics for Drug-Resistant Gonorrhea and Chlamydia Coinfections
Butler, Michelle M, Waidyarachchi, Samanthi L, Connolly, Kristie L, Jerse, Ann E, Chai, Weirui, Lee, Richard E, Kohlhoff, Stephan A, Shinabarger, Dean L, Bowlin, Terry L
Published in Antimicrobial agents and chemotherapy (01.05.2018)
Published in Antimicrobial agents and chemotherapy (01.05.2018)
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Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β‑Lactamase Inhibitors
Gupta, Rashmi, Al-Kharji, Noora M. S. A, Alqurafi, Maha A, Nguyen, Thu Q, Chai, Weirui, Quan, Pojun, Malhotra, Riya, Simcox, Breven S, Mortimer, Phil, Brammer Basta, Leighanne A, Rohde, Kyle H, Buynak, John D
Published in ACS infectious diseases (13.08.2021)
Published in ACS infectious diseases (13.08.2021)
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β‑Lactamase Inhibition by 7‑Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-Enzyme
Rodkey, Elizabeth A, McLeod, David C, Bethel, Christopher R, Smith, Kerri M, Xu, Yan, Chai, Weirui, Che, Tao, Carey, Paul R, Bonomo, Robert A, van den Akker, Focco, Buynak, John D
Published in Journal of the American Chemical Society (11.12.2013)
Published in Journal of the American Chemical Society (11.12.2013)
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Journal Article
Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV‑1 β‑Lactamase and 6β-(Hydroxymethyl)penicillanic Acid Sulfone
Che, Tao, Rodkey, Elizabeth A, Bethel, Christopher R, Shanmugam, Sivaprakash, Ding, Zhe, Pusztai-Carey, Marianne, Nottingham, Michael, Chai, Weirui, Buynak, John D, Bonomo, Robert A, van den Akker, Focco, Carey, Paul R
Published in Biochemistry (Easton) (27.01.2015)
Published in Biochemistry (Easton) (27.01.2015)
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Urazole synthesis. Part 2: facilitating N-4 substitution
Chai, Weirui, Nguyen, Emily, Doran, Jennifer, Han, Katie, Weatherbie, Alexander, Fernandez, Daniel, Karimi, Sarah, Mynam, Ritwick, Humphrey, Caroline, Rana, Sara, Buynak, John D.
Published in Tetrahedron letters (08.05.2013)
Published in Tetrahedron letters (08.05.2013)
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Journal Article
Urazole synthesis. Part 2: facilitating N4 substitution
Chai, Weirui, Nguyen, Emily, Doran, Jennifer, Han, Katie, Weatherbie, Alexander, Fernandez, Daniel, Karimi, Sarah, Mynam, Ritwick, Humphrey, Caroline, Rana, Sara, Buynak, John D.
Published in Tetrahedron letters (08.05.2013)
Published in Tetrahedron letters (08.05.2013)
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Journal Article
Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBPla and Acinetobacter sp. PBP3
PAPP-WALLACE, Krisztina M, SENKFOR, Baui, SKALWEIT, Marion J, HARRIS, Michael E, RICE, Louis B, BUYNAK, John D, BONOMO, Robert A, GATTA, Julian, CHAI, Weirui, TARACILA, Magdalena A, SHANMUGASUNDARAM, Veerabahu, HAN, Seungil, ZANIEWSKI, Richard P, LACEY, Brian M, TOMARAS, Andrew P
Published in Antimicrobial agents and chemotherapy (2012)
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Published in Antimicrobial agents and chemotherapy (2012)
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C5-substituted carbapenem antibiotics, compositions containing such compounds, and methods of use in treatment of Mycobacterium tuberculosis and non-tubercular mycobacteria
Al-Kharji, Noora M. S. A, Nguyen, Thu Q, Alqurafi, Maha, Gupta, Rashmi, Chai, Weirui, Rohde, Kyle, Buynak, John D
Year of Publication 07.07.2020
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Year of Publication 07.07.2020
Patent
C5-SUBSTITUTED CARBAPENEM ANTIBIOTICS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF USE IN TREATMENT OF MYCOBACTERIUM TUBERCULOSIS AND NON-TUBERCULAR MYCOBACTERIA
Al-Kharji, Noora M. S. A, Nguyen, Thu Q, Alqurafi, Maha, Gupta, Rashmi, Chai, Weirui, Rohde, Kyle, Buynak, John D
Year of Publication 13.12.2018
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Year of Publication 13.12.2018
Patent