Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes
Xia, Yan, Chackalamannil, Samuel, Greenlee, William J., Jayne, Charles, Neustadt, Bernard, Stamford, Andrew, Vaccaro, Henry, Xu, Xiaoying (Lucy), Baker, Hana, O’Neill, Kim, Woods, Morgan, Hawes, Brian, Kowalski, Tim
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Journal Article
Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents
Chackalamannil, Samuel, Xia, Yan, Greenlee, William J, Clasby, Martin, Doller, Darìo, Tsai, Hsingan, Asberom, Theodros, Czarniecki, Michael, Ahn, Ho-Sam, Boykow, George, Foster, Carolyn, Agans-Fantuzzi, Jacqueline, Bryant, Matthew, Lau, Janice, Chintala, Madhu
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
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Journal Article
Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist
Clasby, Martin C, Chackalamannil, Samuel, Czarniecki, Michael, Doller, Dario, Eagen, Keith, Greenlee, William, Kao, Grace, Lin, Yan, Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Foster, Carolyn, Smith-Torhan, April, Alton, Kevin, Bryant, Matthew, Hsieh, Yunsheng, Lau, Janice, Palamanda, Jairam
Published in Journal of medicinal chemistry (11.01.2007)
Published in Journal of medicinal chemistry (11.01.2007)
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Journal Article
The role of exploratory drug metabolism and pharmacokinetics in new drug research: case study-selection of a thrombin receptor antagonist for development
Hsieh, Yunsheng, Cheng, K-C, Wang, Yuguang, Chackalamannil, Samuel, Xia, Yan, Korfmacher, Walter A, White, Ronald E
Published in Current pharmaceutical design (01.07.2009)
Published in Current pharmaceutical design (01.07.2009)
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Journal Article
Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core
Clasby, Martin C., Chackalamannil, Samuel, Czarniecki, Michael, Doller, Darío, Eagen, Keith, Greenlee, William J., Lin, Yan, Tagat, Jayaram R., Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Hsieh, Yunsheng, McPhail, Andrew T.
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Journal Article
Total Synthesis of (+)-Himbacine and (+)-Himbeline
Chackalamannil, Samuel, Davies, Robert J, Wang, Yuguang, Asberom, Theodros, Doller, Darío, Wong, Jesse, Leone, Daria, McPhail, Andrew T
Published in Journal of organic chemistry (19.03.1999)
Published in Journal of organic chemistry (19.03.1999)
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Journal Article
A Highly Efficient Total Synthesis of (+)-Himbacine
Chackalamannil, Samuel, Davies, Robert J, Asberom, Theodros, Doller, Darío, Leone, Daria
Published in Journal of the American Chemical Society (09.10.1996)
Published in Journal of the American Chemical Society (09.10.1996)
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Journal Article
Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists
Doller, Darío, Chackalamannil, Samuel, Czarniecki, Michael, McQuade, Robert, Ruperto, Vilma
Published in Bioorganic & medicinal chemistry letters (22.03.1999)
Published in Bioorganic & medicinal chemistry letters (22.03.1999)
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Journal Article
Synthesis of Mono- and Difluoronaphthoic Acids
Tagat, Jayaram R, McCombie, Stuart W, Nazareno, Dennis V, Boyle, Craig D, Kozlowski, Joseph A, Chackalamannil, Samuel, Josien, Hubert, Wang, Yuguang, Zhou, Guowei
Published in Journal of organic chemistry (22.02.2002)
Published in Journal of organic chemistry (22.02.2002)
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Journal Article
Synthesis and Evaluation of Polycyclic Pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP Phosphodiesterase Inhibitors
Xia, Yan, Chackalamannil, Samuel, Czarniecki, Michael, Tsai, Hsingan, Vaccaro, Henry, Cleven, Renee, Cook, John, Fawzi, Ahmad, Watkins, Robert, Zhang, Hongtao
Published in Journal of medicinal chemistry (19.12.1997)
Published in Journal of medicinal chemistry (19.12.1997)
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Journal Article
Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity
Chackalamannil, Samuel, Wang, Yuguang, Greenlee, William J, Hu, Zhiyong, Xia, Yan, Ahn, Ho-Sam, Boykow, George, Hsieh, Yunsheng, Palamanda, Jairam, Agans-Fantuzzi, Jacqueline, Kurowski, Stan, Graziano, Michael, Chintala, Madhu
Published in Journal of medicinal chemistry (12.06.2008)
Published in Journal of medicinal chemistry (12.06.2008)
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Journal Article
Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists
SHAH, Unmesh, LANKIN, Claire M, HONGTAO ZHANG, LACHOWICZ, Jean E, BOYLE, Craig D, CHACKALAMANNIL, Samuel, GREENLEE, William J, NEUSTADT, Bernard R, COHEN-WILLIAMS, Mary E, HIGGINS, Guy A, NG, Kwokei, VARTY, Geoffrey B
Published in Bioorganic & medicinal chemistry letters (01.07.2008)
Published in Bioorganic & medicinal chemistry letters (01.07.2008)
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Journal Article
Discovery of hydroxy pyrimidine Factor IXa inhibitors
Jayne, Charles L., Andreani, Teresa, Chan, Tin-Yau, Chelliah, Mariappan V., Clasby, Martin C., Dwyer, Michael, Eagen, Keith A., Fried, Steve, Greenlee, William J., Guo, Zhuyan, Hawes, Brian, Hruza, Alan, Ingram, Richard, Keertikar, Kartik M., Neelamkavil, Santhosh, Reichert, Paul, Xia, Yan, Chackalamannil, Samuel
Published in Bioorganic & medicinal chemistry letters (01.08.2020)
Published in Bioorganic & medicinal chemistry letters (01.08.2020)
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Journal Article
Design and Synthesis of P2–P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors
Velázquez, Francisco, Chelliah, Mariappan, Clasby, Martin, Guo, Zhuyan, Howe, John, Miller, Randy, Neelamkavil, Santhosh, Shah, Unmesh, Soriano, Aileen, Xia, Yan, Venkatraman, Srikanth, Chackalamannil, Samuel, Davies, Ian W
Published in ACS medicinal chemistry letters (08.12.2016)
Published in ACS medicinal chemistry letters (08.12.2016)
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Journal Article
Discovery of MK-8282 as a Potent G‑Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes
Neelamkavil, Santhosh F, Stamford, Andrew W, Kowalski, Timothy, Biswas, Dipshikha, Boyle, Craig, Chackalamannil, Samuel, Xia, Yan, Jayne, Charles, Neustadt, Bernard, Hao, Jinsong, Liu, Hong, Dai, Xing, Baker, Hana, Hawes, Brian, O’Neill, Kim, Tang, Huadong, Greenlee, William J
Published in ACS medicinal chemistry letters (10.05.2018)
Published in ACS medicinal chemistry letters (10.05.2018)
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Journal Article
Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor
Neelamkavil, Santhosh F, Agrawal, Sony, Bara, Thomas, Bennett, Chad, Bhat, Sathesh, Biswas, Dipshikha, Brockunier, Linda, Buist, Nicole, Burnette, Duane, Cartwright, Mark, Chackalamannil, Samuel, Chase, Robert, Chelliah, Mariappan, Chen, Austin, Clasby, Martin, Colandrea, Vincent J, Davies, Ian W, Eagen, Keith, Guo, Zhuyan, Han, Yongxin, Howe, John, Jayne, Charles, Josien, Hubert, Kargman, Stacia, Marcantonio, Karen, Miao, Shouwu, Miller, Randy, Nolting, Andrew, Pinto, Patrick, Rajagopalan, Murali, Ruck, Rebecca T, Shah, Unmesh, Soriano, Aileen, Sperbeck, Donald, Velazquez, Francisco, Wu, Jin, Xia, Yan, Venkatraman, Srikanth
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
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Journal Article