A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
Talukdar, Saswata, Zhou, Yingjiang, Li, Dongmei, Rossulek, Michelle, Dong, Jennifer, Somayaji, Veena, Weng, Yan, Clark, Ronald, Lanba, Adhiraj, Owen, Bryn M., Brenner, Martin B., Trimmer, Jeffrey K., Gropp, Kathryn E., Chabot, Jeffrey R., Erion, Derek M., Rolph, Timothy P., Goodwin, Bryan, Calle, Roberto A.
Published in Cell metabolism (08.03.2016)
Published in Cell metabolism (08.03.2016)
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Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury
Xu, Jinghai J., Henstock, Peter V., Dunn, Margaret C., Smith, Arthur R., Chabot, Jeffrey R., de Graaf, David
Published in Toxicological sciences (01.09.2008)
Published in Toxicological sciences (01.09.2008)
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Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice
Weng, Yan, Chabot, Jeffrey R, Bernardo, Barbara, Yan, Qingyun, Zhu, Yimin, Brenner, Martin B, Vage, Chandra, Logan, Alison, Calle, Roberto, Talukdar, Saswata
Published in PloS one (19.03.2015)
Published in PloS one (19.03.2015)
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Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation
Fung, Ella, Kang, Liya, Sapashnik, Diana, Benard, Susan, Sievers, Annette, Liu, Yan, Yan, Guoying, Zhou, Jing, Rodriguez, Linette, Ma, Weijun, Stochaj, Wayne R, LaVallie, Edward, Wroblewska, Liliana, Kelleher, Kerry, Tam, Amy, Bezy, Olivier, Breen, Danna, Chabot, Jeffrey R, He, Tao, Lin, Laura, Wu, Zhidan, Mosyak, Lidia
Published in Scientific reports (26.04.2021)
Published in Scientific reports (26.04.2021)
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Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock
van Oudenaarden, Alexander, Chabot, Jeffrey R, Pedraza, Juan M, Luitel, Prashant
Published in Nature (20.12.2007)
Published in Nature (20.12.2007)
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Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome
Dong, Jennifer Q, Gosset, James R, Fahmi, Odette A, Lin, Zhiwu, Chabot, Jeffrey R, Terra, Steven G, Le, Vu, Chidsey, Kristin, Nouri, Parya, Kim, Albert, Buckbinder, Leonard, Kalgutkar, Amit S
Published in Drug metabolism and disposition (01.05.2017)
Published in Drug metabolism and disposition (01.05.2017)
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A Mechanistic Site-Of-Action Model: A Tool for Informing Right Target, Right Compound, And Right Dose for Therapeutic Antagonistic Antibody Programs
Kapitanov, Georgi I., Chabot, Jeffrey R., Narula, Jatin, Roy, Mahua, Neubert, Hendrik, Palandra, Joe, Farrokhi, Vahid, Johnson, Jay S., Webster, Robert, Jones, Hannah M.
Published in Frontiers in bioinformatics (03.09.2021)
Published in Frontiers in bioinformatics (03.09.2021)
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Assessing the Feasibility of Neutralizing Osteopontin with Various Therapeutic Antibody Modalities
Farrokhi, Vahid, Chabot, Jeffrey R, Neubert, Hendrik, Yang, Zhiyong
Published in Scientific reports (17.05.2018)
Published in Scientific reports (17.05.2018)
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Journal Article
Once‐weekly administration of a long‐acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non‐human primates
Kim, Albert M., Somayaji, Veena R., Dong, Jennifer Q., Rolph, Timothy P., Weng, Yan, Chabot, Jeffrey R., Gropp, Kathryn E., Talukdar, Saswata, Calle, Roberto A.
Published in Diabetes, obesity & metabolism (01.12.2017)
Published in Diabetes, obesity & metabolism (01.12.2017)
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Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents
Londregan, Allyn T, Wei, Liuqing, Xiao, Jun, Lintner, Nathanael G, Petersen, Donna, Dullea, Robert G, McClure, Kim F, Bolt, Michael W, Warmus, Joseph S, Coffey, Steven B, Limberakis, Chris, Genovino, Julien, Thuma, Benjamin A, Hesp, Kevin D, Aspnes, Gary E, Reidich, Benjamin, Salatto, Christopher T, Chabot, Jeffrey R, Cate, Jamie H. D, Liras, Spiros, Piotrowski, David W
Published in Journal of medicinal chemistry (12.07.2018)
Published in Journal of medicinal chemistry (12.07.2018)
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Liver‐Targeted Small‐Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis
McClure, Kim F., Piotrowski, David W., Petersen, Donna, Wei, Liuqing, Xiao, Jun, Londregan, Allyn T., Kamlet, Adam S., Dechert‐Schmitt, Anne‐Marie, Raymer, Brian, Ruggeri, Roger B., Canterbury, Daniel, Limberakis, Chris, Liras, Spiros, DaSilva‐Jardine, Paul, Dullea, Robert G., Loria, Paula M., Reidich, Benjamin, Salatto, Christopher T., Eng, Heather, Kimoto, Emi, Atkinson, Karen, King‐Ahmad, Amanda, Scott, Dennis, Beaumont, Kevin, Chabot, Jeffrey R., Bolt, Michael W., Maresca, Kevin, Dahl, Kenneth, Arakawa, Ryosuke, Takano, Akihiro, Halldin, Christer
Published in Angewandte Chemie International Edition (18.12.2017)
Published in Angewandte Chemie International Edition (18.12.2017)
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Physiologically relevant binding affinity quantification of monoclonal antibody PF‐00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation
Wang, Mengmeng, Kussrow, Amanda K, Ocana, Mireia Fernandez, Chabot, Jeffrey R, Lepsy, Christopher S, Bornhop, Darryl J, O'Hara, Denise M
Published in British journal of pharmacology (01.01.2017)
Published in British journal of pharmacology (01.01.2017)
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Journal Article
Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing
Weng, Yan, Ishino, Tetsuya, Sievers, Annette, Talukdar, Saswata, Chabot, Jeffrey R, Tam, Amy, Duan, Weili, Kerns, Kelvin, Sousa, Eric, He, Tao, Logan, Alison, Lee, Darwin, Li, Dongmei, Zhou, Yingjiang, Bernardo, Barbara, Joyce, Alison, Kavosi, Mania, O'Hara, Denise M, Clark, Tracey, Guo, Jie, Giragossian, Craig, Stahl, Mark, Calle, Roberto A, Kriz, Ron, Somers, Will, Lin, Laura
Published in Scientific reports (09.03.2018)
Published in Scientific reports (09.03.2018)
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Journal Article
Liver‐Targeted Small‐Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis
McClure, Kim F., Piotrowski, David W., Petersen, Donna, Wei, Liuqing, Xiao, Jun, Londregan, Allyn T., Kamlet, Adam S., Dechert‐Schmitt, Anne‐Marie, Raymer, Brian, Ruggeri, Roger B., Canterbury, Daniel, Limberakis, Chris, Liras, Spiros, DaSilva‐Jardine, Paul, Dullea, Robert G., Loria, Paula M., Reidich, Benjamin, Salatto, Christopher T., Eng, Heather, Kimoto, Emi, Atkinson, Karen, King‐Ahmad, Amanda, Scott, Dennis, Beaumont, Kevin, Chabot, Jeffrey R., Bolt, Michael W., Maresca, Kevin, Dahl, Kenneth, Arakawa, Ryosuke, Takano, Akihiro, Halldin, Christer
Published in Angewandte Chemie (18.12.2017)
Published in Angewandte Chemie (18.12.2017)
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Pendent polyimides using mellitic acid dianhydride. III. The effect of pendent group functionality on polymer properties
Illingsworth, Marvin L, Wang, Wei, McCarney, Jonathan P, Hughes, Kenneth A, Trotter, Kari J, Stapleton, Russell A, Chabot, Jeffrey R, Siochi, Emilie J, Kotlarchyk, Michael
Published in Journal of applied polymer science (15.07.2009)
Published in Journal of applied polymer science (15.07.2009)
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Abstract 3056: Growth differentiation factor 15 (GDF-15) inhibition attenuates platinum-based chemotherapy-induced emesis, anorexia and weight loss and increases survival
Breen, Danna M., Beaumont, Kevin, Bennett, Donald, Brosnan, Julia, Calle, Roberto, Chabot, Jeffrey R., Collins, Susie, Cunio, Teresa, Esquejo, Ryan M., Joaquim, Stephanie, Joyce, Alison, Kim, Hanna, Lin, Laura, Pettersen, Betty, Qiao, Shuxi, Rossulek, Michelle, Tierney, Brendan, Walters, Karen M., Weber, Gregory, Wu, Zhidan, Zhang, Bei B., Birnbaum, Morris J.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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