The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors
Graham, Thomas H., Shen, Hong C., Liu, Wensheng, Xiong, Yusheng, Verras, Andreas, Bleasby, Kelly, Bhatt, Urmi R., Chabin, Renee M., Chen, Dunlu, Chen, Qing, Garcia-Calvo, Margarita, Geissler, Wayne M., He, Huaibing, Lassman, Michael E., Shen, Zhu, Tong, Xinchun, Tung, Elaine C., Xie, Dan, Xu, Suoyu, Colletti, Steven L., Tata, James R., Hale, Jeffrey J., Pinto, Shirly, Shen, Dong-Ming
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Design and Synthesis of Prolylcarboxypeptidase (PrCP) Inhibitors To Validate PrCP As A Potential Target for Obesity
Zhou, Changyou, Garcia-Calvo, Margareta, Pinto, Shirly, Lombardo, Matthew, Feng, Zhe, Bender, Kate, Pryor, KellyAnn D, Bhatt, Urmi R, Chabin, Renee M, Geissler, Wayne M, Shen, Zhu, Tong, Xinchun, Zhang, Zhoupeng, Wong, Kenny K, Roy, Ranabir Sinha, Chapman, Kevin T, Yang, Lihu, Xiong, Yusheng
Published in Journal of medicinal chemistry (14.10.2010)
Published in Journal of medicinal chemistry (14.10.2010)
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Journal Article
Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors
Shen, Hong C., Ding, Fa-Xiang, Zhou, Changyou, Xiong, Yusheng, Verras, Andreas, Chabin, Renee M., Xu, Suoyu, Tong, Xinchun, Xie, Dan, Lassman, Michael E., Bhatt, Urmi R., Garcia-Calvo, Margarita M., Geissler, Wayne, Shen, Zhu, Chen, Dunlu, SinhaRoy, Ranabir, Hale, Jeffery J., Tata, James R., Pinto, Shirly, Shen, Dong-Ming, Colletti, Steven L.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Journal Article
Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine
Wu, Zhicai, Yang, Cangming, Xiong, Yusheng, Feng, Zhe, Lombardo, Matthew, Verras, Andreas, Chabin, Renee M., Xu, Suoyu, Tong, Xinchun, Xie, Dan, Lassman, Mike E., Bhatt, Urmi R., Garcia-Calvo, Margarita M., Geissler, Wayne, Shen, Zhu, Chen, Qing, Sinharoy, Ranabir, Hale, Jeffrey J., Tata, James R., Pinto, Shirly, Shen, Dong-Ming, Colletti, Steven L.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors
Shen, Hong C., Ding, Fa-Xiang, Jiang, Jinlong, Verras, Andreas, Chabin, Renee M., Xu, Suoyu, Tong, Xinchun, Chen, Qing, Xie, Dan, Lassman, Mike E., Bhatt, Urmi R., Garcia-Calvo, Margarita M., Geissler, Wayne, Shen, Zhu, Murphy, Beth Ann, Gorski, Judith N., Wiltsie, Judyann, SinhaRoy, Ranabir, Hale, Jeffrey J., Pinto, Shirly, Shen, Dong-Ming
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors
Wu, Zhicai, Yang, Cangming, Graham, Thomas H., Verras, Andreas, Chabin, Renee M., Xu, Suoyu, Tong, Xinchun, Xie, Dan, Lassman, Mike E., Bhatt, Urmi R., Garcia-Calvo, Margarita M., Shen, Zhu, Chen, Qing, Bleasby, Kelly, Sinharoy, Ranabir, Hale, Jeffrey J., Tata, James R., Pinto, Shirly, Colletti, Steven L., Shen, Dong-Ming
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase
Guthikonda, Ravindra N., Shah, Shrenik K., Pacholok, Stephen G., Humes, John L., Mumford, Richard A., Grant, Stephan K., Chabin, Renee M., Green, Barbara G., Tsou, Nancy, Ball, Richard, Fletcher, Daniel S., Luell, Silvi, Euan MacIntyre, D., MacCoss, Malcolm
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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Journal Article
Inhibitors of the bacterial cell wall biosynthesis enzyme Mur D
Gegnas, Laura D., Waddell, Sherman T., Chabin, Renee M., Reddy, Sreelatha, Wong, Kenny K.
Published in Bioorganic & medicinal chemistry letters (01.07.1998)
Published in Bioorganic & medicinal chemistry letters (01.07.1998)
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Journal Article
Engineering a Cell-Free Murein Biosynthetic Pathway: Combinatorial Enzymology in Drug Discovery
Wong, Kenny K, Kuo, David W, Chabin, Renee M, Fournier, Carole, Gegnas, Laura D, Waddell, Sherman T, Marsilio, Frank, Leiting, Barbara, Pompliano, David L
Published in Journal of the American Chemical Society (30.12.1998)
Published in Journal of the American Chemical Society (30.12.1998)
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Journal Article
Active-Site Structure Analysis of Recombinant Human Inducible Nitric Oxide Synthase Using Imidazole
Chabin, Renee M, McCauley, Ermenegilda, Calaycay, Jimmy R, Kelly, Theresa M, MacNaul, Karen L, Wolfe, Gloria C, Hutchinson, Nancy I, Madhusudanaraju, Sayyaparaju, Schmidt, John A, Kozarich, John W, Wong, Kenny K
Published in Biochemistry (Easton) (23.07.1996)
Published in Biochemistry (Easton) (23.07.1996)
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Journal Article
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases
Hagmann, William K, Caldwell, Charles G, Chen, Ping, Durette, Philippe L, Esser, Craig K, Lanza, Thomas J, Kopka, Ihor E, Guthikonda, Ravi, Shah, Shrenik K, MacCoss, Malcolm, Chabin, Renee M, Fletcher, Daniel, Grant, Stephan K, Green, Barbara G, Humes, John L, Kelly, Theresa M, Luell, Sylvie, Meurer, Roger, Moore, Vernon, Pacholok, Stephen G, Pavia, Tony, Williams, Hollis R, Wong, Kenny K
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
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Journal Article
Phosphorous acid analogs of L-680,833, a potent monocyclic β-lactam inhibitor of human leukocyte elastase
Durette, Philippe L., Chabin, Renee M., Fletcher, Daniel S., Green, Barbara G., Hanlon, William A., Humes, John L., Knight, Wilson B., Lanza, Thomas J., Mumford, Richard A., Pacholok, Stephen, MacCoss, Malcolm
Published in Bioorganic & medicinal chemistry letters (02.02.1995)
Published in Bioorganic & medicinal chemistry letters (02.02.1995)
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Journal Article
Metabolic pathway assay
WONG; KENNY K, KUO; DAVID W, POMPLIANO; DAVID L, CHABIN; RENEE M, O'CONNELL; JOHN F
Year of Publication 06.04.1999
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Year of Publication 06.04.1999
Patent
Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
WILLIAM F. HOFFMAN, PHILIPPE L. DURETTE, RAVINDRA K GUTHIKONDA, CRAIG K ESSER, SHRENIK K. SHAH, WILLIAM K. HAGMANN, KENNY K WONG, CHARLES G CALDWELL, RENEE M CHABIN, MALCOLM MACCOSS
Year of Publication 03.07.1996
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Year of Publication 03.07.1996
Patent
SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE
SHAH, SHRENIK, K, HOFFMAN, WILLIAM, F, CHABIN, RENEE, M, GUTHIKONDA, RAVINDRA, K, HAGMANN, WILLIAM, K, CALDWELL, CHARLES, G, MACCOSS, MALCOLM, WONG, KENNY, K, DURETTE, PHILIPPE, L, ESSER, CRAIG, K
Year of Publication 20.06.1996
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Year of Publication 20.06.1996
Patent