An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies
O'Neil, Jennifer, Benita, Yair, Feldman, Igor, Chenard, Melissa, Roberts, Brian, Liu, Yaping, Li, Jing, Kral, Astrid, Lejnine, Serguei, Loboda, Andrey, Arthur, William, Cristescu, Razvan, Haines, Brian B, Winter, Christopher, Zhang, Theresa, Bloecher, Andrew, Shumway, Stuart D
Published in Molecular cancer therapeutics (01.06.2016)
Published in Molecular cancer therapeutics (01.06.2016)
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A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors
Loboda, Andrey, Nebozhyn, Michael, Klinghoffer, Rich, Frazier, Jason, Chastain, Michael, Arthur, William, Roberts, Brian, Zhang, Theresa, Chenard, Melissa, Haines, Brian, Andersen, Jannik, Nagashima, Kumiko, Paweletz, Cloud, Lynch, Bethany, Feldman, Igor, Dai, Hongyue, Huang, Pearl, Watters, James
Published in BMC genomics (30.06.2010)
Published in BMC genomics (30.06.2010)
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Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2)
Witter, David J., Harrington, Paul, Wilson, Kevin J., Chenard, Melissa, Fleming, Judith C., Haines, Brian, Kral, Astrid M., Secrist, J. Paul, Miller, Thomas A.
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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A Quantitative Volumetric Micro-Computed Tomography Method to Analyze Lung Tumors in Genetically Engineered Mouse Models
Haines, Brian B., Bettano, Kimberly A., Chenard, Melissa, Sevilla, Raquel S., Ware, Christopher, Angagaw, Minilik H., Winkelmann, Christopher T., Tong, Christopher, Reilly, John F., Sur, Cyrille, Zhang, Weisheng
Published in Neoplasia (New York, N.Y.) (01.01.2009)
Published in Neoplasia (New York, N.Y.) (01.01.2009)
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Gastric cancer cell lines as models to study human digestive functions
Basque, Jean-René, Chénard, Mélissa, Chailler, Pierre, Ménard, Daniel
Published in Journal of cellular biochemistry (01.05.2001)
Published in Journal of cellular biochemistry (01.05.2001)
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SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2)
METHOT, Joey L, HAMBLETT, Christopher L, HONGMEI WANG, KRAL, Astrid M, OZEROVA, Nicole, CRUZ, Jonathan C, HAINES, Brian, CHENARD, Melissa, KENIFIC, Candia M, SECRIST, J. Paul, MILLER, Thomas A, MAMPREIAN, Dawn M, JUNG, Joon, HARSCH, Andreas, SZEWCZAK, Alexander A, DAHLBERG, William K, MIDDLETON, Richard E, HUGHES, Bethany, FLEMING, Judith C
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors
Hamblett, Christopher L., Methot, Joey L., Mampreian, Dawn M., Sloman, David L., Stanton, Matthew G., Kral, Astrid M., Fleming, Judith C., Cruz, Jonathan C., Chenard, Melissa, Ozerova, Nicole, Hitz, Anna M., Wang, Hongmei, Deshmukh, Sujal V., Nazef, Naim, Harsch, Andreas, Hughes, Bethany, Dahlberg, William K., Szewczak, Alex A., Middleton, Richard E., Mosley, Ralph T., Secrist, J. Paul, Miller, Thomas A.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2)
HEIDEBRECHT, Richard W, CHENARD, Melissa, KRAL, Astrid M, MIDDLETON, Richard E, MUSHTI, Chandrasekhar, OZEROVA, Nicole, SZEWCZAK, Alexander A, HONGMEI WANG, WILSON, Kevin, WITTER, David J, SECRIST, J. Paul, MILLER, Thomas A, CLOSE, Joshua, DAHLBERG, William K, FLEMING, Judith, GRIMM, Jonathan B, HAMILL, Julie E, HARSCH, Andreas, HAINES, Brian B, HUGHES, Bethany
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells
Bouley, Richard, Sun, Tian-Xiao, Chenard, Melissa, McLaughlin, Margaret, McKee, Mary, Lin, Herbert Y, Brown, Dennis, Ausiello, Dennis A
Published in American Journal of Physiology: Cell Physiology (01.10.2003)
Published in American Journal of Physiology: Cell Physiology (01.10.2003)
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Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression
Hayes, Tikvah K., Neel, Nicole F., Hu, Chaoxin, Gautam, Prson, Chenard, Melissa, Long, Brian, Aziz, Meraj, Kassner, Michelle, Bryant, Kirsten L., Pierobon, Mariaelena, Marayati, Raoud, Kher, Swapnil, George, Samuel D., Xu, Mai, Wang-Gillam, Andrea, Samatar, Ahmed A., Maitra, Anirban, Wennerberg, Krister, Petricoin, Emanuel F., Yin, Hongwei H., Nelkin, Barry, Cox, Adrienne D., Yeh, Jen Jen, Der, Channing J.
Published in Cancer cell (11.01.2016)
Published in Cancer cell (11.01.2016)
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Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1)
WILSON, Kevin J, WITTER, David J, CHENARD, Melissa, SZEWCZAK, Alexander A, MIDDLETON, Richard E, HUGHES, Bethany L, DAHLBERG, William K, SECRIST, J. Paul, MILLER, Thomas A, GRIMM, Jonathan B, SILIPHAIVANH, Phieng, OTTE, Karin M, KRAL, Astrid M, FLEMING, Judith C, HARSCH, Andreas, HAMILL, Julie E, CRUZ, Jonathan C
Published in Bioorganic & medicinal chemistry letters (01.03.2008)
Published in Bioorganic & medicinal chemistry letters (01.03.2008)
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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)
Methot, Joey L., Chakravarty, Prasun K., Chenard, Melissa, Close, Joshua, Cruz, Jonathan C., Dahlberg, William K., Fleming, Judith, Hamblett, Christopher L., Hamill, Julie E., Harrington, Paul, Harsch, Andreas, Heidebrecht, Richard, Hughes, Bethany, Jung, Joon, Kenific, Candia M., Kral, Astrid M., Meinke, Peter T., Middleton, Richard E., Ozerova, Nicole, Sloman, David L., Stanton, Matthew G., Szewczak, Alexander A., Tyagarajan, Sriram, Witter, David J., Paul Secrist, J., Miller, Thomas A.
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Divergent Kinetics Differentiate the Mechanism of Action of Two HDAC Inhibitors
Kral, Astrid M, Ozerova, Nicole, Close, Joshua, Jung, Joon, Chenard, Melissa, Fleming, Judith, Haines, Brian B, Harrington, Paul, Maclean, John, Miller, Thomas A, Secrist, Paul, Wang, Hongmei, Heidebrecht, Richard W
Published in Biochemistry (Easton) (04.02.2014)
Published in Biochemistry (Easton) (04.02.2014)
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MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
PAN, Bo-Sheng, CHAN, Grace K. Y, JEWELL, James P, KARIV, Ilona, KATZ, Jason D, KUNII, Kaiko, WEI LU, LUTTERBACH, Bart A, PAWELETZ, Cloud P, XIANLU QU, REILLY, John F, SZEWCZAK, Alexander A, CHENARD, Melissa, QINWEN ZENG, KOHL, Nancy E, DINSMORE, Christopher J, CHI, An, DAVIS, Lenora J, DESHMUKH, Sujal V, GIBBS, Jackson B, GIL, Susana, GAOZHEN HANG, HATCH, Harold
Published in Cancer research (Chicago, Ill.) (15.02.2010)
Published in Cancer research (Chicago, Ill.) (15.02.2010)
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Discovery of 1‑[3-(1-Methyl‑1H‑pyrazol-4-yl)-5-oxo‑5H‑benzo[4,5]cyclohepta[1,2‑b]pyridin-7-yl]‑N‑(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c‑Met/Ron Dual Kinase Inhibitor with Preferential Affinity for the Activated State of c‑Met
Northrup, Alan B, Katcher, Matthew H, Altman, Michael D, Chenard, Melissa, Daniels, Matthew H, Deshmukh, Sujal V, Falcone, Danielle, Guerin, David J, Hatch, Harold, Li, Chaomin, Lu, Wei, Lutterbach, Bart, Allison, Timothy J, Patel, Sangita B, Reilly, John F, Reutershan, Michael, Rickert, Keith W, Rosenstein, Craig, Soisson, Stephen M, Szewczak, Alexander A, Walker, Deborah, Wilson, Kevin, Young, Jonathan R, Pan, Bo-Sheng, Dinsmore, Christopher J
Published in Journal of medicinal chemistry (28.03.2013)
Published in Journal of medicinal chemistry (28.03.2013)
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Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor
Methot, Joey L, Hoffman, Dawn Mampreian, Witter, David J, Stanton, Matthew G, Harrington, Paul, Hamblett, Christopher, Siliphaivanh, Phieng, Wilson, Kevin, Hubbs, Jed, Heidebrecht, Richard, Kral, Astrid M, Ozerova, Nicole, Fleming, Judith C, Wang, Hongmei, Szewczak, Alexander A, Middleton, Richard E, Hughes, Bethany, Cruz, Jonathan C, Haines, Brian B, Chenard, Melissa, Kenific, Candia M, Harsch, Andreas, Secrist, J. Paul, Miller, Thomas A
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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T cell activation and anti-tumor efficacy of anti-LAG-3 antibodies is independent of LAG-3 – MHCII blocking capacity
Cemerski, Saso, Zhao, Shuxia, Chenard, Melissa, Laskey, Jason, Cui, Long, Shukla, Rinkan, Haines, Brian, Hsieh, Edward, Beaumont, Maribel, Mattson, Jeanine, Blumenschein, Wendy, Hirsch, Heather, Fayadat-Dilman, Laurence, Liang, Linda, De Waal Malefyt, Rene
Published in Journal for immunotherapy of cancer (04.11.2015)
Published in Journal for immunotherapy of cancer (04.11.2015)
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Abstract 3478: PI3K suppression by the mTOR inhibitor ridaforolimus and the AKT inhibitor MK-2206 is associated with enhanced anti-tumor activity and hyperglycemia in preclinical models
Artime, Marlene C., Blackman, Samuel, Ebbinghaus, Scot, Lee, Ray, Bacco, Alessandra Di, Gargano, Diana, Zhang, Theresa, Muniappa, Nagaraja, Sandhu, Punam, Gitzlaff, Gail, Chavez-Eng, Cynthia, Watters, James, Chenard, Melissa, Clark, Edwin, Winter, Christopher, Haines, Brian B.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization
Kattar, Solomon D., Surdi, Laura M., Zabierek, Anna, Methot, Joey L., Middleton, Richard E., Hughes, Bethany, Szewczak, Alexander A., Dahlberg, William K., Kral, Astrid M., Ozerova, Nicole, Fleming, Judith C., Wang, Hongmei, Secrist, Paul, Harsch, Andreas, Hamill, Julie E., Cruz, Jonathan C., Kenific, Candia M., Chenard, Melissa, Miller, Thomas A., Berk, Scott C., Tempest, Paul
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
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