Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death
Magnaghi, Paola, D'Alessio, Roberto, Valsasina, Barbara, Avanzi, Nilla, Rizzi, Simona, Asa, Daniela, Gasparri, Fabio, Cozzi, Liviana, Cucchi, Ulisse, Orrenius, Christian, Polucci, Paolo, Ballinari, Dario, Perrera, Claudia, Leone, Antonella, Cervi, Giovanni, Casale, Elena, Xiao, Yang, Wong, Chihunt, Anderson, Daniel J, Galvani, Arturo, Donati, Daniele, O'Brien, Tom, Jackson, Peter K, Isacchi, Antonella
Published in Nature chemical biology (01.09.2013)
Published in Nature chemical biology (01.09.2013)
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Journal Article
Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors
Cervi, Giovanni, D'Alessio, Roberto, Bindi, Simona, Buffa, Laura, Burocchi, Alessia, Canevari, Giulia, Modugno, Michele, Motto, Ilaria, Saturno, Grazia, Orsini, Paolo
Published in European journal of medicinal chemistry (15.04.2024)
Published in European journal of medicinal chemistry (15.04.2024)
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Journal Article
Identification of N,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor
Brasca, Maria Gabriella, Amboldi, Nadia, Ballinari, Dario, Cameron, Alexander, Casale, Elena, Cervi, Giovanni, Colombo, Maristella, Colotta, Francesco, Croci, Valter, D’Alessio, Roberto, Fiorentini, Francesco, Isacchi, Antonella, Mercurio, Ciro, Moretti, Walter, Panzeri, Achille, Pastori, Wilma, Pevarello, Paolo, Quartieri, Francesca, Roletto, Fulvia, Traquandi, Gabriella, Vianello, Paola, Vulpetti, Anna, Ciomei, Marina
Published in Journal of medicinal chemistry (27.08.2009)
Published in Journal of medicinal chemistry (27.08.2009)
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Journal Article
Abstract 4036: NMS-0963 is a novel potent, selective and orally available Syk inhibitor with promising preclinical activity in diffuse large B-cell lymphoma
Saturno, Grazia, Modugno, Michele, Orsini, Paolo, Cervi, Giovanni, Buffa, Laura, Motto, Ilaria, Avanzi, Nilla, Montemartini, Marisa, Gasparri, Fabio, Texido, Gemma, Galvani, Arturo, Isacchi, Antonella
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Discovery of 2‑(Cyclohexylmethylamino)pyrimidines as a New Class of Reversible Valosine Containing Protein Inhibitors
Cervi, Giovanni, Magnaghi, Paola, Asa, Daniela, Avanzi, Nilla, Badari, Alessandra, Borghi, Daniela, Caruso, Michele, Cirla, Alessandra, Cozzi, Liviana, Felder, Eduard, Galvani, Arturo, Gasparri, Fabio, Lomolino, Antonio, Magnuson, Steven, Malgesini, Beatrice, Motto, Ilaria, Pasi, Maurizio, Rizzi, Simona, Salom, Barbara, Sorrentino, Graziella, Troiani, Sonia, Valsasina, Barbara, O’Brien, Thomas, Isacchi, Antonella, Donati, Daniele, D’Alessio, Roberto
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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Journal Article
Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases
Casuscelli, Francesco, Ardini, Elena, Avanzi, Nilla, Casale, Elena, Cervi, Giovanni, D’Anello, Matteo, Donati, Daniele, Faiardi, Daniela, Ferguson, Ronald D., Fogliatto, Gianpaolo, Galvani, Arturo, Marsiglio, Aurelio, Mirizzi, Danilo G., Montemartini, Marisa, Orrenius, Christian, Papeo, Gianluca, Piutti, Claudia, Salom, Barbara, Felder, Eduard R.
Published in Bioorganic & medicinal chemistry (01.12.2013)
Published in Bioorganic & medicinal chemistry (01.12.2013)
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Journal Article
Thieno[3,2- c]pyrazoles: A novel class of Aurora inhibitors with favorable antitumor activity
Bindi, Simona, Fancelli, Daniele, Alli, Cristina, Berta, Daniela, Bertrand, Jay A., Cameron, Alexander D., Cappella, Paolo, Carpinelli, Patrizia, Cervi, Giovanni, Croci, Valter, D’Anello, Matteo, Forte, Barbara, Laura Giorgini, M., Marsiglio, Aurelio, Moll, Juergen, Pesenti, Enrico, Pittalà, Valeria, Pulici, Maurizio, Riccardi-Sirtori, Federico, Roletto, Fulvia, Soncini, Chiara, Storici, Paola, Varasi, Mario, Volpi, Daniele, Zugnoni, Paola, Vianello, Paola
Published in Bioorganic & medicinal chemistry (01.10.2010)
Published in Bioorganic & medicinal chemistry (01.10.2010)
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Journal Article
Bicyclic carbohydrate-derived scaffolds for combinatorial libraries
Cervi, Giovanni, Peri, Francesco, Battistini, Carlo, Gennari, Cesare, Nicotra, Francesco
Published in Bioorganic & medicinal chemistry (15.05.2006)
Published in Bioorganic & medicinal chemistry (15.05.2006)
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Journal Article
Synthesis of a beta-Carboline Scaffold Properly Functionalized for the Generation of Libraries of Bioactive Compounds
La Ferla, Barbara, Orsato, Alexandre, Zona, Cristiano, Cervi, Giovanni, Papeo, Gianluca, Felder, Eduard R., Nicotra, Francesco
Published in Synthesis (Stuttgart) (01.02.2010)
Published in Synthesis (Stuttgart) (01.02.2010)
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Journal Article
Abstract 2940: Identification of potent VCP/p97/CDC48 inhibitors with distinct biochemical mechanisms including a reversible, allosteric inhibitor that activates the unfolded protein response, induce autophagy and cancer cell death
Magnaghi, Paola, D'Alessio, Roberto, Valsasina, Barbara, Avanzi, Nilla R., Rizzi, Simona, Asa, Daniela, Gasparri, Fabio, Cozzi, Liviana, Cucchi, Ulisse, Orrenius, Cristian, Polucci, Paolo, Ballinari, Dario, Perrera, Claudia, Leone, Antonella, Cervi, Giovanni, Galvani, Arturo, Donati, Daniele, O'Brien, Tom, Jackson, Peter K., Isacchi, Antonella
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Identification of N ,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1 H -pyrazolo[4,3- h ]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor
Brasca, Maria Gabriella, Amboldi, Nadia, Ballinari, Dario, Cameron, Alexander, Casale, Elena, Cervi, Giovanni, Colombo, Maristella, Colotta, Francesco, Croci, Valter, D’Alessio, Roberto, Fiorentini, Francesco, Isacchi, Antonella, Mercurio, Ciro, Moretti, Walter, Panzeri, Achille, Pastori, Wilma, Pevarello, Paolo, Quartieri, Francesca, Roletto, Fulvia, Traquandi, Gabriella, Vianello, Paola, Vulpetti, Anna, Ciomei, Marina
Published in Journal of medicinal chemistry (27.08.2009)
Published in Journal of medicinal chemistry (27.08.2009)
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Journal Article
PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
CERVI, Giovanni, BUFFA, Laura, BINDI, Simona, MENICHINCHERI, Maria, MODUGNO, Michele, D'ALESSIO, Roberto
Year of Publication 29.08.2024
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Year of Publication 29.08.2024
Patent
PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
CERVI, Giovanni, BUFFA, Laura, D ALESSIO, Roberto, BINDI, Simona, MENICHINCHERI, Maria, MODUGNO, Michele
Year of Publication 02.08.2023
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Year of Publication 02.08.2023
Patent
PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
CERVI, Giovanni, BUFFA, Laura, BINDI, Simona, MENICHINCHERI, Maria, MODUGNO, Michele, D'ALESSIO, Roberto
Year of Publication 31.03.2022
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Year of Publication 31.03.2022
Patent
3,4-DIARIL PIRAZOIS COMO INIBIDORES DA PROTEÍNA QUINASE
GABRIELLA TRAQUANDI, MICHELE MODUGNO, STEFANO NUVOLONI, ALESSANDRA BADARI, CHIARA MARCHIONNI, FABIO ZUCCOTTO, SONIA BIONDARO, GIOVANNI CERVI, PAOLO TRIFIRO, MAURIZIO PULICI
Year of Publication 23.08.2022
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Year of Publication 23.08.2022
Patent
ChemInform Abstract: Critical Survey Covering 2007: Solid-Phase Synthesis
Carenzi, Davide, Cervi, Giovanni, Felder, Eduard, Mirizzi, Danilo, Salom, Barbara
Published in ChemInform (09.03.2010)
Published in ChemInform (09.03.2010)
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Journal Article
Pyrazolyl-pyrimidine derivatives as kinase inhibitors
CASUSCELLI FRANCESCO, DISINGRINI TERESA, QUARTIERI FRANCESCA, CALDARELLI MARINA, BRASCA MARIA GABRIELLA, CERVI GIOVANNI
Year of Publication 15.03.2016
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Year of Publication 15.03.2016
Patent