Redox exchange of the disulfides of human two-domain CD4 regulates the conformational dynamics of each domain, providing insight into its mechanisms of control
Owen, Gavin R., Le, Doris, Stoychev, Stoyan, Cerutti, Nichole M., Papathanasopoulos, Maria
Published in Biochemical and biophysical research communications (04.03.2018)
Published in Biochemical and biophysical research communications (04.03.2018)
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Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2
Owen, Gavin R, Channell, Jennifer A, Forsyth, V. Trevor, Haertlein, Michael, Mitchell, Edward P, Capovilla, Alexio, Papathanasopoulos, Maria, Cerutti, Nichole M
Published in Biochemistry (Easton) (19.04.2016)
Published in Biochemistry (Easton) (19.04.2016)
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Env–2dCD4S60C complexes act as super immunogens and elicit potent, broadly neutralizing antibodies against clinically relevant human immunodeficiency virus type 1 (HIV-1)
Killick, Mark A, Grant, Michelle L, Cerutti, Nichole M, Capovilla, Alexio, Papathanasopoulos, Maria A
Published in Vaccine (01.11.2015)
Published in Vaccine (01.11.2015)
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Disulfide Reduction in CD4 Domain 1 or 2 Is Essential for Interaction with HIV Glycoprotein 120 (gp120), which Impairs Thioredoxin-driven CD4 Dimerization
Cerutti, Nichole, Killick, Mark, Jugnarain, Vinesh, Papathanasopoulos, Maria, Capovilla, Alexio
Published in The Journal of biological chemistry (11.04.2014)
Published in The Journal of biological chemistry (11.04.2014)
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Journal Article
Env-2dCD4S60Ccomplexes act as super immunogens and elicit potent, broadly neutralizing antibodies against clinically relevant human immunodeficiency virus type 1 (HIV-1)
Killick, Mark A, Grant, Michelle L, Cerutti, Nichole M, Capovilla, Alexio, Papathanasopoulos, Maria A
Published in Vaccine (17.11.2015)
Published in Vaccine (17.11.2015)
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Structural studies of dynamic CD4 changes relevant to HIV infection
Channell, Jennifer Anne, Moulin, Martine, Owen, Gavin, Cerutti, Nichole, Haertlein, Michael, Mitchell, Edward, Papathanasopoulos, Maria, Forsyth, Trevor
Published in Acta crystallographica. Section A, Foundations and advances (01.12.2017)
Published in Acta crystallographica. Section A, Foundations and advances (01.12.2017)
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Stabilization of HIV-1 gp120-CD4 Receptor Complex through Targeted Interchain Disulfide Exchange
Cerutti, Nichole, Mendelow, Barry V., Napier, Grant B., Papathanasopoulos, Maria A., Killick, Mark, Khati, Makobetsa, Stevens, Wendy, Capovilla, Alexio
Published in The Journal of biological chemistry (13.08.2010)
Published in The Journal of biological chemistry (13.08.2010)
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Journal Article
Env-2dCD4 S60C complexes act as super immunogens and elicit potent, broadly neutralizing antibodies against clinically relevant human immunodeficiency virus type 1 (HIV-1)
Killick, Mark A, Grant, Michelle L, Cerutti, Nichole M, Capovilla, Alexio, Papathanasopoulos, Maria A
Published in Vaccine (17.11.2015)
Published in Vaccine (17.11.2015)
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Journal Article