Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Angst, Daniela, Gessier, François, Janser, Philipp, Vulpetti, Anna, Wälchli, Rudolf, Beerli, Christian, Littlewood-Evans, Amanda, Dawson, Janet, Nuesslein-Hildesheim, Barbara, Wieczorek, Grazyna, Gutmann, Sascha, Scheufler, Clemens, Hinniger, Alexandra, Zimmerlin, Alfred, Funhoff, Enrico G, Pulz, Robert, Cenni, Bruno
Published in Journal of medicinal chemistry (28.05.2020)
Published in Journal of medicinal chemistry (28.05.2020)
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Remibrutinib (LOU064): A selective potent oral BTK inhibitor with promising clinical safety and pharmacodynamics in a randomized phase I trial
Kaul, Martin, End, Peter, Cabanski, Maciej, Schuhler, Carole, Jakab, Annamaria, Kistowska, Magdalena, Kinhikar, Arvind, Maiolica, Alessio, Sinn, Angela, Fuhr, Rainard, Cenni, Bruno
Published in Clinical and translational science (01.09.2021)
Published in Clinical and translational science (01.09.2021)
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Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of multiple sclerosis
Nuesslein-Hildesheim, Barbara, Ferrero, Enrico, Schmid, Cindy, Huck, Catherine, Smith, Paul, Tisserand, Sarah, Rubert, Joelle, Bornancin, Frederic, Eichlisberger, Denis, Cenni, Bruno
Published in Journal of neuroinflammation (26.08.2023)
Published in Journal of neuroinflammation (26.08.2023)
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Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling
Holopainen, Tanja, Räsänen, Markus, Anisimov, Andrey, Tuomainen, Tomi, Zheng, Wei, Tvorogov, Denis, Hulmi, Juha J., Andersson, Leif C., Cenni, Bruno, Tavi, Pasi, Mervaala, Eero, Kivelä, Riikka, Alitalo, Kari
Published in Proceedings of the National Academy of Sciences - PNAS (20.10.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (20.10.2015)
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Remibrutinib inhibits hives effector cells stimulated by serum from chronic urticaria patients independently of FcεR1 expression level and omalizumab clinical response
Gimeno, Ramón, Ribas‐Llauradó, Clara, Pesque, David, Andrades, Evelyn, Cenni, Bruno, Ambros, Barbara, Pujol, Ramon, Giménez‐Arnau, Ana M.
Published in Clinical and translational allergy (01.03.2023)
Published in Clinical and translational allergy (01.03.2023)
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BMX and Its Role in Inflammation, Cardiovascular Disease, and Cancer
Cenni, Bruno, Gutmann, Sascha, Gottar-Guillier, Marie
Published in International Reviews of Immunology (01.04.2012)
Published in International Reviews of Immunology (01.04.2012)
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Efficacy and safety of remibrutinib, a selective potent oral BTK inhibitor, in Sjögren’s syndrome: results from a randomised, double-blind, placebo-controlled phase 2 trial
Dörner, Thomas, Kaul, Martin, Szántó, Antónia, Tseng, Jui-Cheng, Papas, Athena S, Pylvaenaeinen, Ilona, Hanser, Malika, Abdallah, Nasri, Grioni, Andrea, Santos Da Costa, Aida, Ferrero, Enrico, Gergely, Peter, Hillenbrand, Rainer, Avrameas, Alexandre, Cenni, Bruno, Siegel, Richard M
Published in Annals of the rheumatic diseases (01.03.2024)
Published in Annals of the rheumatic diseases (01.03.2024)
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Design of Potent and Selective Covalent Inhibitors of Bruton’s Tyrosine Kinase Targeting an Inactive Conformation
Pulz, Robert, Angst, Daniela, Dawson, Janet, Gessier, Francois, Gutmann, Sascha, Hersperger, Rene, Hinniger, Alexandra, Janser, Philipp, Koch, Guido, Revesz, Laszlo, Vulpetti, Anna, Waelchli, Rudolf, Zimmerlin, Alfred, Cenni, Bruno
Published in ACS medicinal chemistry letters (10.10.2019)
Published in ACS medicinal chemistry letters (10.10.2019)
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Evaluation of protease‐activated receptor 2 in murine models of arthritis
Busso, Nathalie, Frasnelli, Matthias, Feifel, Roland, Cenni, Bruno, Steinhoff, Martin, Hamilton, Justin, So, Alexander
Published in Arthritis and rheumatism (01.01.2007)
Published in Arthritis and rheumatism (01.01.2007)
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다발성 경화증 치료를 위한 LOU064
JUHNKE MICHAEL, SIN KIM HIEN, YU HUIXIN, BIETH BRUNO, KARAN RAJESH SINGH, GRAHAM GORDON, END PETER, MANN ALLISON DONNA, BHATTACHARYA SOUVIK, ZHANG YING, RAPP KARIN, CENNI BRUNO, PIGEOLET ETIENNE
Year of Publication 26.04.2024
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Year of Publication 26.04.2024
Patent
The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner
Gottar-Guillier, Marie, Dodeller, Francis, Huesken, Dieter, Iourgenko, Vadim, Mickanin, Craig, Labow, Mark, Gaveriaux, Samuel, Kinzel, Bernd, Mueller, Matthias, Alitalo, Kari, Littlewood-Evans, Amanda, Cenni, Bruno
Published in The Journal of immunology (1950) (15.05.2011)
Published in The Journal of immunology (1950) (15.05.2011)
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브루톤 티로신 키나제 저해제를 이용하여 만성 자발성 두드러기를 치료하는 방법
BHATTACHARYA SOUVIK, VITALITI GARAMI ALESSANDRA, SEVERIN THOMAS, BIETH BRUNO, CABANSKI MACIEJ, CENNI BRUNO, KAUL MARTIN, STORIM JULIAN, DE BUCK STEFAN, KINHIKAR ARVIND, RADIVOJEVIC ANDRIJANA
Year of Publication 03.02.2022
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Year of Publication 03.02.2022
Patent
브루톤 타이로신 키나제 저해제를 사용하여 쇼그렌 증후군을 치료하는 방법
BHATTACHARYA SOUVIK, VITALITI GARAMI ALESSANDRA, BIETH BRUNO, CABANSKI MACIEJ, CENNI BRUNO, KAUL MARTIN, DE BUCK STEFAN, KINHIKAR ARVIND, RADIVOJEVIC ANDRIJANA
Year of Publication 28.01.2022
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Year of Publication 28.01.2022
Patent
Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells
Maggiolini, M, Bonofiglio, D, Marsico, S, Panno, M L, Cenni, B, Picard, D, Andò, S
Published in Molecular pharmacology (01.09.2001)
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Published in Molecular pharmacology (01.09.2001)
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Ligand-independent Activation of Steroid Receptors: New Roles for Old Players
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