Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
Quintás-Cardama, Alfonso, Vaddi, Kris, Liu, Phillip, Manshouri, Taghi, Li, Jun, Scherle, Peggy A, Caulder, Eian, Wen, Xiaoming, Li, Yanlong, Waeltz, Paul, Rupar, Mark, Burn, Timothy, Lo, Yvonne, Kelley, Jennifer, Covington, Maryanne, Shepard, Stacey, Rodgers, James D, Haley, Patrick, Kantarjian, Hagop, Fridman, Jordan S, Verstovsek, Srdan
Published in Blood (15.04.2010)
Published in Blood (15.04.2010)
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Selective Inhibition of ADAM Metalloproteases as a Novel Approach for Modulating ErbB Pathways in Cancer
Fridman, Jordan S, Caulder, Eian, Hansbury, Michael, Liu, Xiangdong, Yang, Genjie, Wang, Qian, Lo, Yvonne, Zhou, Bin-Bing, Pan, Maxwell, Thomas, Sufi M, Grandis, Jennifer R, Zhuo, Jincong, Yao, Wenqing, Newton, Robert C, Friedman, Steven M, Scherle, Peggy A, Vaddi, Kris
Published in Clinical cancer research (15.03.2007)
Published in Clinical cancer research (15.03.2007)
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INCB16562, a JAK1/2 Selective Inhibitor, Is Efficacious against Multiple Myeloma Cells and Reverses the Protective Effects of Cytokine and Stromal Cell Support
Li, Jun, Favata, Margaret, Kelley, Jennifer A., Caulder, Eian, Thomas, Beth, Wen, Xiaoming, Sparks, Richard B., Arvanitis, Ari, Rogers, James D., Combs, Andrew P., Vaddi, Kris, Solomon, Kimberly A., Scherle, Peggy A., Newton, Robert, Fridman, Jordan S.
Published in Neoplasia (New York, N.Y.) (01.01.2010)
Published in Neoplasia (New York, N.Y.) (01.01.2010)
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Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo
Burger, Renate, Le Gouill, Steven, Tai, Yu-Tzu, Shringarpure, Reshma, Tassone, Pierfrancesco, Neri, Paola, Podar, Klaus, Catley, Laurence, Hideshima, Teru, Chauhan, Dharminder, Caulder, Eian, Neilan, Claire L, Vaddi, Kris, Li, Jun, Gramatzki, Martin, Fridman, Jordan S, Anderson, Kenneth C
Published in Molecular cancer therapeutics (01.01.2009)
Published in Molecular cancer therapeutics (01.01.2009)
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Journal Article
Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab
Liu, Xiangdong, Fridman, Jordan S., Wang, Qian, Caulder, Eian, Yang, Gengjie, Covington, Maryanne, Liu, Changnian, Marando, Cindy, Zhuo, Jincong, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Newton, Robert C., Scherle, Peggy A., Friedman, Steven M.
Published in Cancer biology & therapy (01.06.2006)
Published in Cancer biology & therapy (01.06.2006)
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Combined Inhibition of Janus Kinase 1/2 for the Treatment of JAK2V617F-Driven Neoplasms: Selective Effects on Mutant Cells and Improvements in Measures of Disease Severity
Liu, Phillip C C, Caulder, Eian, Li, Jun, Waeltz, Paul, Margulis, Alex, Wynn, Richard, Becker-Pasha, Mary, Li, Yanlong, Crowgey, Erin, Hollis, Gregory, Haley, Patrick, Sparks, Richard B, Combs, Andrew P, Rodgers, James D, Burn, Timothy C, Vaddi, Kris, Fridman, Jordan S
Published in Clinical cancer research (15.11.2009)
Published in Clinical cancer research (15.11.2009)
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Journal Article
Synergistic Inhibition with a Dual Epidermal Growth Factor Receptor/ HER-2/neu Tyrosine Kinase Inhibitor and a Disintegrin and Metalloprotease Inhibitor
WITTERS, Lois, SCHERLE, Peggy, FRIEDMAN, Steven, FRIDMAN, Jordan, CAULDER, Eian, NEWTON, Robert, LIPTON, Allan
Published in Cancer research (Chicago, Ill.) (01.09.2008)
Published in Cancer research (Chicago, Ill.) (01.09.2008)
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Journal Article
Abstract 779: Blockade of the IL-6/JAK/STAT3 signaling pathway inhibits pancreatic tumor cell growth in 3D spheroid cultures and in xenograft models
Li, Jun, Caulder, Eian, Favata, Margaret, Diamond, Melody, Rumberger, Beth, Koblish, Holly, Huang, Taisheng, Xue, Chu-Biao, Yao, Wenqing, Fridman, Jordan, Scherle, Peggy, Liu, Mike, Huber, Reid, Vaddi, Kris
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 692: The BET inhibitor INCB054329 is synergistic with JAK1 inhibition in models of multiple myeloma
Stubbs, Matthew C., Liu, Xuesong M., Wen, Xiaoming, Li, Jun, Dostalik, Valerie, O'Connor, Sybil, Caulder, Eian, Favata, Margaret, Rupar, Mark, Li, Yu, Rumberger, Beth, Maduskuie, Thomas, Sparks, Richard, Falahatpisheh, Nikoo, Polam, Padmaja, Vaddi, Kris, Burn, Timothy, Combs, Andrew P., Yao, Wenqing, Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip CC
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 691: Activity of the BET inhibitor INCB054329 in models of multiple myeloma
Stubbs, Matthew, Wen, Xiaoming, Dostalik, Valerie, O'Connor, Sybil, Caulder, Eian, Vogina, Alla, Maduskuie, Thomas, Sparks, Richard, Huang, Taisheng, Falahatpisheh, Nikoo, Polam, Padmaja, Xue, Chu-Biao, Liu, Xuesong M., Burn, Timothy, Vaddi, Kris, Combs, Andrew P., Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip CC
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract B266: Systemic inflammation and tissue atrophy in cancer cachexia is mediated by cytokine-dependent protease activation: Physiological and functional improvements through JAK1/2 inhibition
Caulder, Eian, Wen, Xiaoming, Kelley, Jennifer, Rodgers, James, Combs, Andrew, Rupar, Mark, Burn, Timothy, Vaddi, Kris, Fridman, Jordan
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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Journal Article
Discovery of a Potent, Selective, and Orally Active Human Epidermal Growth Factor Receptor-2 Sheddase Inhibitor for the Treatment of Cancer
Yao, Wenqing, Zhuo, Jincong, Burns, David M, Xu, Meizhong, Zhang, Colin, Li, Yun-Long, Qian, Ding-Quan, He, Chunhong, Weng, Lingkai, Shi, Eric, Lin, Qiyan, Agrios, Costas, Burn, Timothy C, Caulder, Eian, Covington, Maryanne B, Fridman, Jordan S, Friedman, Steven, Katiyar, Kamna, Hollis, Gregory, Li, Yanlong, Liu, Changnian, Liu, Xiangdong, Marando, Cindy A, Newton, Robert, Pan, Max, Scherle, Peggy, Taylor, Nancy, Vaddi, Kris, Wasserman, Zelda R, Wynn, Richard, Yeleswaram, Swamy, Jalluri, Ravi, Bower, Michael, Zhou, Bing-Bing, Metcalf, Brian
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Journal Article
The JAK Inhibitor INCB20 Induces Antiproliferative and Apoptotic Effects in Human Myeloma Cells In Vitro and In Vivo
Burger, Renate, Legouill, Steven, Tai, Yu-Tzu, Shringarpure, Reshma, Podar, Klaus, Catley, Laurence, Tassone, Pierfrancesco, Neri, Paola, Hideshima, Teru, Chauhan, Dharminder, Caulder, Eian, Vaddi, Kris, Neilan, Claire L., Gramatzki, Martin, Fridman, Jordan S., Anderson, Kenneth C.
Published in Blood (16.11.2005)
Published in Blood (16.11.2005)
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