Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Chamberlain, Philip P, Lopez-Girona, Antonia, Miller, Karen, Carmel, Gilles, Pagarigan, Barbra, Chie-Leon, Barbara, Rychak, Emily, Corral, Laura G, Ren, Yan J, Wang, Maria, Riley, Mariko, Delker, Silvia L, Ito, Takumi, Ando, Hideki, Mori, Tomoyuki, Hirano, Yoshinori, Handa, Hiroshi, Hakoshima, Toshio, Daniel, Thomas O, Cathers, Brian E
Published in Nature structural & molecular biology (01.09.2014)
Published in Nature structural & molecular biology (01.09.2014)
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Journal Article
p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates
Van Nguyen, Thang, Li, Jing, Lu, Chin-Chun (Jean), Mamrosh, Jennifer L., Lu, Gang, Cathers, Brian E., Deshaies, Raymond J.
Published in Proceedings of the National Academy of Sciences - PNAS (04.04.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (04.04.2017)
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Journal Article
Cereblon modulators: Low molecular weight inducers of protein degradation
Chamberlain, Philip P., Cathers, Brian E.
Published in Drug discovery today. Technologies (01.04.2019)
Published in Drug discovery today. Technologies (01.04.2019)
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Journal Article
Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity
Gandhi, Anita K., Mendy, Derek, Waldman, Michelle, Chen, Gengxin, Rychak, Emily, Miller, Karen, Gaidarova, Svetlana, Ren, Yan, Wang, Maria, Breider, Michael, Carmel, Gilles, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Cathers, Brian E., Schafer, Peter H., Daniel, Tom O., Lopez‐Girona, Antonia, Thakurta, Anjan, Chopra, Rajesh
Published in British journal of haematology (01.01.2014)
Published in British journal of haematology (01.01.2014)
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Journal Article
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase
Matyskiela, Mary E, Lu, Gang, Ito, Takumi, Pagarigan, Barbra, Lu, Chin-Chun, Miller, Karen, Fang, Wei, Wang, Nai-Yu, Nguyen, Derek, Houston, Jack, Carmel, Gilles, Tran, Tam, Riley, Mariko, Nosaka, Lyn'Al, Lander, Gabriel C, Gaidarova, Svetlana, Xu, Shuichan, Ruchelman, Alexander L, Handa, Hiroshi, Carmichael, James, Daniel, Thomas O, Cathers, Brian E, Lopez-Girona, Antonia, Chamberlain, Philip P
Published in Nature (London) (14.07.2016)
Published in Nature (London) (14.07.2016)
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Journal Article
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos
Matyskiela, Mary E, Zhang, Weihong, Man, Hon-Wah, Muller, George, Khambatta, Godrej, Baculi, Frans, Hickman, Matthew, LeBrun, Laurie, Pagarigan, Barbra, Carmel, Gilles, Lu, Chin-Chun, Lu, Gang, Riley, Mariko, Satoh, Yoshitaka, Schafer, Peter, Daniel, Thomas O, Carmichael, James, Cathers, Brian E, Chamberlain, Philip P
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound
Sun, Daekyu, Thompson, Brian, Cathers, Brian E, Salazar, Miguel, Kerwin, Sean M, Trent, John O, Jenkins, Terence C, Neidle, Stephen, Hurley, Laurence H
Published in Journal of medicinal chemistry (04.07.1997)
Published in Journal of medicinal chemistry (04.07.1997)
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Journal Article
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS
Krönke, Jan, Fink, Emma C, Hollenbach, Paul W, MacBeth, Kyle J, Hurst, Slater N, Udeshi, Namrata D, Chamberlain, Philip P, Mani, D R, Man, Hon Wah, Gandhi, Anita K, Svinkina, Tanya, Schneider, Rebekka K, McConkey, Marie, Järås, Marcus, Griffiths, Elizabeth, Wetzler, Meir, Bullinger, Lars, Cathers, Brian E, Carr, Steven A, Chopra, Rajesh, Ebert, Benjamin L
Published in Nature (London) (09.07.2015)
Published in Nature (London) (09.07.2015)
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Journal Article
CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia
Hansen, Joshua D, Correa, Matthew, Alexander, Matt, Nagy, Mark, Huang, Dehua, Sapienza, John, Lu, Gang, LeBrun, Laurie A, Cathers, Brian E, Zhang, Weihong, Tang, Yang, Ammirante, Massimo, Narla, Rama K, Piccotti, Joseph R, Pourdehnad, Michael, Lopez-Girona, Antonia
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Journal Article
Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice
Dufu, Kobina, Williams, Alexander T., Muller, Cynthia R., Walser, Cynthia M., Lucas, Alfredo, Eaker, Allyn M., Alt, Carsten, Cathers, Brian E., Oksenberg, Donna, Cabrales, Pedro
Published in American journal of physiology. Heart and circulatory physiology (01.08.2021)
Published in American journal of physiology. Heart and circulatory physiology (01.08.2021)
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Journal Article
GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model
Dufu, Kobina, Alt, Carsten, Strutt, Steven, Partridge, James, Tang, Tzechiang, Siu, Vincent, Liao‐Zou, Hilary, Rademacher, Peter, Williams, Alexander T., Muller, Cynthia R., Geng, Xin, Pochron, Mira Patel, Dang, Annie Nguyen, Cabrales, Pedro, Li, Zhe, Oksenberg, Donna, Cathers, Brian E.
Published in British journal of haematology (01.07.2023)
Published in British journal of haematology (01.07.2023)
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Journal Article
Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase
Xu, Shuichan, Abbasian, Mahan, Patel, Palka, Jensen-Pergakes, Kristen, Lombardo, Christian R., Cathers, Brian E., Xie, Weilin, Mercurio, Frank, Pagano, Michele, Giegel, David, Cox, Sarah
Published in The Journal of biological chemistry (25.05.2007)
Published in The Journal of biological chemistry (25.05.2007)
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Journal Article
Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma
Rychak, Emily, Mendy, Derek, Shi, Tao, Ning, Yuhong, Leisten, Jim, Lu, Ling, Miller, Karen, Narla, Rama K., Orlowski, Robert Z., Raymon, Heather K., Bjorklund, Chad C., Thakurta, Anjan, Gandhi, Anita K., Cathers, Brian E., Chopra, Rajesh, Daniel, Thomas O., Lopez‐Girona, Antonia
Published in British journal of haematology (01.03.2016)
Published in British journal of haematology (01.03.2016)
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Journal Article
Discovery of the Selective Protein Kinase C-theta Kinase Inhibitor, CC-90005
Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S., Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E.
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Journal Article
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization
Mortensen, Deborah S, Fultz, Kimberly E, Xu, Shuichan, Xu, Weiming, Packard, Garrick, Khambatta, Godrej, Gamez, James C, Leisten, Jim, Zhao, Jingjing, Apuy, Julius, Ghoreishi, Kamran, Hickman, Matt, Narla, Rama Krishna, Bissonette, Rene, Richardson, Samantha, Peng, Sophie X, Perrin-Ninkovic, Sophie, Tran, Tam, Shi, Tao, Yang, Wen Qing, Tong, Zeen, Cathers, Brian E, Moghaddam, Mehran F, Canan, Stacie S, Worland, Peter, Sankar, Sabita, Raymon, Heather K
Published in Molecular cancer therapeutics (01.06.2015)
Published in Molecular cancer therapeutics (01.06.2015)
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Journal Article
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor
Plantevin Krenitsky, Véronique, Nadolny, Lisa, Delgado, Mercedes, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Hegde, Sayee, D’Sidocky, Neil, Sapienza, John, Wright, Jonathan, McCarrick, Meg, Bahmanyar, Sogole, Chamberlain, Philip, Delker, Silvia L., Muir, Jeff, Giegel, David, Xu, Li, Celeridad, Maria, Lachowitzer, Jeff, Bennett, Brydon, Moghaddam, Mehran, Khatsenko, Oleg, Katz, Jason, Fan, Rachel, Bai, April, Tang, Yang, Shirley, Michael A., Benish, Brent, Bodine, Tracey, Blease, Kate, Raymon, Heather, Cathers, Brian E., Satoh, Yoshitaka
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
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Journal Article
Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223
Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
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Journal Article
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury
Krenitsky, Véronique Plantevin, Delgado, Mercedes, Nadolny, Lisa, Sahasrabudhe, Kiran, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Kois, Adam, Hughes, Kevin, Wright, Jonathan, Nowakowski, Jacek, Sudbeck, Elise, Ghosh, Sutapa, Bahmanyar, Sogole, Chamberlain, Philip, Muir, Jeff, Cathers, Brian E., Giegel, David, Xu, Li, Celeridad, Maria, Moghaddam, Mehran, Khatsenko, Oleg, Omholt, Paul, Katz, Jason, Pai, Sema, Fan, Rachel, Tang, Yang, Shirley, Michael A., Benish, Brent, Blease, Kate, Raymon, Heather, Bhagwat, Shripad, Henderson, Ian, Cole, Andrew G., Bennett, Brydon, Satoh, Yoshitaka
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
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Journal Article
A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
Matyskiela, Mary E., Lu, Gang, Ito, Takumi, Pagarigan, Barbra, Lu, Chin-Chun, Miller, Karen, Fang, Wei, Wang, Nai-Yu, Nguyen, Derek, Houston, Jack, Carmel, Gilles, Tran, Tam, Riley, Mariko, Nosaka, Lyn’Al, Lander, Gabriel C., Gaidarova, Svetlana, Xu, Shuichan, Ruchelman, Alexander L., Handa, Hiroshi, Carmichael, James, Daniel, Thomas O., Cathers, Brian E., Lopez-Girona, Antonia, Chamberlain, Philip P.
Published in Nature (London) (22.06.2016)
Published in Nature (London) (22.06.2016)
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