Discovery of Highly Selective Brain-Penetrant Vasopressin 1a Antagonists for the Potential Treatment of Autism via a Chemogenomic and Scaffold Hopping Approach
Ratni, Hasane, Rogers-Evans, Mark, Bissantz, Caterina, Grundschober, Christophe, Moreau, Jean-Luc, Schuler, Franz, Fischer, Holger, Alvarez Sanchez, Ruben, Schnider, Patrick
Published in Journal of medicinal chemistry (12.03.2015)
Published in Journal of medicinal chemistry (12.03.2015)
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Journal Article
Protein-based virtual screening of chemical databases. II. Are homology models of g-protein coupled receptors suitable targets?
Bissantz, Caterina, Bernard, Philippe, Hibert, Marcel, Rognan, Didier
Published in Proteins, structure, function, and bioinformatics (01.01.2003)
Published in Proteins, structure, function, and bioinformatics (01.01.2003)
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Journal Article
Translational PK/PD for the Development of Novel Antibiotics-A Drug Developer's Perspective
Bissantz, Caterina, Zampaloni, Claudia, David-Pierson, Pascale, Dieppois, Guennaelle, Guenther, Andreas, Trauner, Andrej, Winther, Lotte, Stubbings, William
Published in Antibiotics (Basel) (01.01.2024)
Published in Antibiotics (Basel) (01.01.2024)
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Journal Article
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
Grether, Uwe, Foxton, Richard H, Gruener, Sabine, Korn, Claudia, Kimbara, Atsushi, Osterwald, Anja, Zirwes, Elisabeth, Uhles, Sabine, Thoele, Janina, Colé, Nadine, Rogers-Evans, Mark, Röver, Stephan, Nettekoven, Matthias, Martin, Rainer E, Adam, Jean-Michel, Fingerle, Jürgen, Bissantz, Caterina, Guba, Wolfgang, Alker, André, Szczesniak, Anna M, Porter, Ross F, Toguri, Tom J, Revelant, Franco, Poirier, Agnès, Perret, Camille, Winther, Lotte, Caruso, Antonello, Fezza, Filomena, Maccarrone, Mauro, Kelly, Melanie E M, Fauser, Sascha, Ullmer, Christoph
Published in Frontiers in pharmacology (12.07.2024)
Published in Frontiers in pharmacology (12.07.2024)
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Journal Article
High-Throughput Modeling of Human G-Protein Coupled Receptors: Amino Acid Sequence Alignment, Three-Dimensional Model Building, and Receptor Library Screening
Bissantz, Caterina, Logean, Antoine, Rognan, Didier
Published in Journal of Chemical Information and Computer Sciences (01.05.2004)
Published in Journal of Chemical Information and Computer Sciences (01.05.2004)
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Journal Article
A Medicinal Chemist’s Guide to Molecular Interactions
Bissantz, Caterina, Kuhn, Bernd, Stahl, Martin
Published in Journal of medicinal chemistry (22.07.2010)
Published in Journal of medicinal chemistry (22.07.2010)
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Journal Article
Me-Talnetant and Osanetant Interact within Overlapping but Not Identical Binding Pockets in the Human Tachykinin Neurokinin 3 Receptor Transmembrane Domains
Malherbe, Pari, Bissantz, Caterina, Marcuz, Anne, Kratzeisen, Claudia, Zenner, Marie-Thérèse, Wettstein, Joseph G, Ratni, Hasane, Riemer, Claus, Spooren, Will
Published in Molecular pharmacology (01.06.2008)
Published in Molecular pharmacology (01.06.2008)
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Journal Article
4-Aminocyclopentane-1,3-diols as platforms for diversity: synthesis of anandamide analogs
Zohrabi-Kalantari, Vida, Jarrahian, Abbas, Bissantz, Caterina, Bergstrom, Donald E, Barker, Eric L, Link, Andreas
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.09.2013)
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.09.2013)
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Journal Article
Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii
Lacroix, Mathilde, Moreau, Jérémy, Zampaloni, Claudia, Bissantz, Caterina, Shirvani, Hamasseh, Marchand, Sandrine, Couet, William, Chauzy, Alexia
Published in International journal of antimicrobial agents (01.07.2024)
Published in International journal of antimicrobial agents (01.07.2024)
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Journal Article
In Vivo Efficacy of Meropenem with a Novel Non-β-Lactam-β-Lactamase Inhibitor, Nacubactam, against Gram-Negative Organisms Exhibiting Various Resistance Mechanisms in a Murine Complicated Urinary Tract Infection Model
Monogue, Marguerite L, Giovagnoli, Sara, Bissantz, Caterina, Zampaloni, Claudia, Nicolau, David P
Published in Antimicrobial agents and chemotherapy (01.09.2018)
Published in Antimicrobial agents and chemotherapy (01.09.2018)
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Journal Article
Meropenem–nacubactam activity against AmpC-overproducing and KPC-expressing Pseudomonas aeruginosa in a neutropenic murine lung infection model
Asempa, Tomefa E., Motos, Ana, Abdelraouf, Kamilia, Bissantz, Caterina, Zampaloni, Claudia, Nicolau, David P.
Published in International journal of antimicrobial agents (01.02.2020)
Published in International journal of antimicrobial agents (01.02.2020)
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Journal Article
Discovery of Balovaptan, a Vasopressin la Receptor Antagonist for the Treatment of Autism Spectrum Disorder
Schnider, Patrick, Bissantz, Caterina, Bruns, Andreas, Dolente, Cosimo, Goetschi, Erwin, Jakob-Roetne, Roland, Kuennecke, Basil, Mueggler, Thomas, Muster, Wolfgang, Parrott, Neil, Pinard, Emmanuel, Ratni, Hasane, Risterucci, Celine, Rogers-Evans, Mark, von Kienlin, Markus, Grundschober, Christophe
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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Journal Article
A novel antibiotic class targeting the lipopolysaccharide transporter
Zampaloni, Claudia, Mattei, Patrizio, Bleicher, Konrad, Winther, Lotte, Thäte, Claudia, Bucher, Christian, Adam, Jean-Michel, Alanine, Alexander, Amrein, Kurt E., Baidin, Vadim, Bieniossek, Christoph, Bissantz, Caterina, Boess, Franziska, Cantrill, Carina, Clairfeuille, Thomas, Dey, Fabian, Di Giorgio, Patrick, du Castel, Pauline, Dylus, David, Dzygiel, Pawel, Felici, Antonio, García-Alcalde, Fernando, Haldimann, Andreas, Leipner, Matthew, Leyn, Semen, Louvel, Séverine, Misson, Pauline, Osterman, Andrei, Pahil, Karanbir, Rigo, Sébastien, Schäublin, Adrian, Scharf, Sebastian, Schmitz, Petra, Stoll, Theodor, Trauner, Andrej, Zoffmann, Sannah, Kahne, Daniel, Young, John A. T., Lobritz, Michael A., Bradley, Kenneth A.
Published in Nature (London) (18.01.2024)
Published in Nature (London) (18.01.2024)
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Journal Article
Efficacy of Human-Simulated Epithelial Lining Fluid Exposure of Meropenem-Nacubactam Combination against Class A Serine β-Lactamase-Producing Enterobacteriaceae in the Neutropenic Murine Lung Infection Model
Asempa, Tomefa E, Motos, Ana, Abdelraouf, Kamilia, Bissantz, Caterina, Zampaloni, Claudia, Nicolau, David P
Published in Antimicrobial agents and chemotherapy (01.04.2019)
Published in Antimicrobial agents and chemotherapy (01.04.2019)
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Journal Article
Stepwise Design of γ‑Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere
Rodríguez Sarmiento, Rosa María, Bissantz, Caterina, Bylund, Johan, Limberg, Anja, Neidhart, Werner, Jakob-Roetne, Roland, Wang, Lisha, Baumann, Karlheinz
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Journal Article
A novel mechanism-based pharmacokinetic–pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria
Kristoffersson, Anders N, Bissantz, Caterina, Okujava, Rusudan, Haldimann, Andreas, Walter, Isabelle, Shi, Tianlai, Zampaloni, Claudia, Nielsen, Elisabet I
Published in Journal of antimicrobial chemotherapy (01.02.2020)
Published in Journal of antimicrobial chemotherapy (01.02.2020)
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Journal Article
A Real-World Perspective on Molecular Design
Kuhn, Bernd, Guba, Wolfgang, Hert, Jérôme, Banner, David, Bissantz, Caterina, Ceccarelli, Simona, Haap, Wolfgang, Körner, Matthias, Kuglstatter, Andreas, Lerner, Christian, Mattei, Patrizio, Neidhart, Werner, Pinard, Emmanuel, Rudolph, Markus G, Schulz-Gasch, Tanja, Woltering, Thomas, Stahl, Martin
Published in Journal of medicinal chemistry (12.05.2016)
Published in Journal of medicinal chemistry (12.05.2016)
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Journal Article
Safety screening in early drug discovery: An optimized assay panel
Bendels, Stefanie, Bissantz, Caterina, Fasching, Bernhard, Gerebtzoff, Grégori, Guba, Wolfgang, Kansy, Manfred, Migeon, Jacques, Mohr, Susanne, Peters, Jens-Uwe, Tillier, Fabien, Wyler, René, Lerner, Christian, Kramer, Christian, Richter, Hans, Roberts, Sonia
Published in Journal of pharmacological and toxicological methods (01.09.2019)
Published in Journal of pharmacological and toxicological methods (01.09.2019)
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Journal Article