Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity
Izzo, Nicholas J, Xu, Jinbin, Zeng, Chenbo, Kirk, Molly J, Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Cruchaga, Carlos, Goate, Alison, Cahill, Michael A, Arancio, Ottavio, Mach, Robert H, Craven, Rolf, Head, Elizabeth, LeVine, 3rd, Harry, Spires-Jones, Tara L, Catalano, Susan M
Published in PloS one (12.11.2014)
Published in PloS one (12.11.2014)
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The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease
Colom-Cadena, Martí, Spires-Jones, Tara, Zetterberg, Henrik, Blennow, Kaj, Caggiano, Anthony, DeKosky, Steven T, Fillit, Howard, Harrison, John E, Schneider, Lon S, Scheltens, Phillip, de Haan, Willem, Grundman, Michael, van Dyck, Christopher H, Izzo, Nicholas J, Catalano, Susan M
Published in Alzheimer's research & therapy (02.03.2020)
Published in Alzheimer's research & therapy (02.03.2020)
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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits
Izzo, Nicholas J, Staniszewski, Agnes, To, Lillian, Fa, Mauro, Teich, Andrew F, Saeed, Faisal, Wostein, Harrison, Walko, 3rd, Thomas, Vaswani, Anisha, Wardius, Meghan, Syed, Zanobia, Ravenscroft, Jessica, Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Finn, Patricia, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Miller, Miles, Johanson, Conrad, Stopa, Edward, Windisch, Manfred, Hutter-Paier, Birgit, Shamloo, Mehrdad, Arancio, Ottavio, LeVine, 3rd, Harry, Catalano, Susan M
Published in PloS one (12.11.2014)
Published in PloS one (12.11.2014)
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Sigma-2 Receptors-From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases
Lizama, Britney N, Kahle, Jennifer, Catalano, Susan M, Caggiano, Anthony O, Grundman, Michael, Hamby, Mary E
Published in International journal of molecular sciences (26.03.2023)
Published in International journal of molecular sciences (26.03.2023)
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Sigma‐2 receptor antagonists rescue neuronal dysfunction induced by Parkinson’s patient brain‐derived α‐synuclein
Limegrover, Colleen S., Yurko, Raymond, Izzo, Nicholas J., LaBarbera, Kelsie M., Rehak, Courtney, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Catalano, Susan M.
Published in Journal of neuroscience research (01.04.2021)
Published in Journal of neuroscience research (01.04.2021)
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Alzheimer’s protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity
Limegrover, Colleen S., LeVine, Harry, Izzo, Nicholas J., Yurko, Raymond, Mozzoni, Kelsie, Rehak, Courtney, Sadlek, Kelsey, Safferstein, Hank, Catalano, Susan M.
Published in Journal of neurochemistry (01.05.2021)
Published in Journal of neurochemistry (01.05.2021)
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Modeling the mature CNS: A predictive screening platform for neurodegenerative disease drug discovery
LaBarbera, Kelsie Mozzoni, Limegrover, Colleen, Rehak, Courtney, Yurko, Raymond, Izzo, Nicholas John, Knezovich, Nicole, Watto, Emily, Waybright, Lora, Catalano, Susan M.
Published in Journal of neuroscience methods (01.07.2021)
Published in Journal of neuroscience methods (01.07.2021)
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Screening of σ 2 Receptor Ligands and In Vivo Evaluation of 11 C-Labeled 6,7-Dimethoxy-2-[4-(4-methoxyphenyl)butan-2-yl]-1,2,3,4-tetrahydroisoquinoline for Potential Use as a σ 2 Receptor Brain PET Tracer
Kim, Ho Young, Lee, Ji Youn, Hsieh, Chia-Ju, Riad, Aladdin, Izzo, Nicholas J, Catalano, Susan M, Graham, Thomas J A, Mach, Robert H
Published in Journal of medicinal chemistry (28.04.2022)
Published in Journal of medicinal chemistry (28.04.2022)
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A phase 1 clinical trial of the sigma-2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimer's disease
Grundman, Michael, Morgan, Roger, Lickliter, Jason D., Schneider, Lon S., DeKosky, Steven, Izzo, Nicholas J., Guttendorf, Robert, Higgin, Michelle, Pribyl, Julie, Mozzoni, Kelsie, Safferstein, Hank, Catalano, Susan M.
Published in Alzheimer's & dementia : translational research & clinical interventions (2019)
Published in Alzheimer's & dementia : translational research & clinical interventions (2019)
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Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
Colom-Cadena, Martí, Toombs, Jamie, Simzer, Elizabeth, Holt, Kristjan, McGeachan, Robert, Tulloch, Jane, Jackson, Rosemary J., Catterson, James H., Spires-Jones, Maxwell P., Rose, Jamie, Waybright, Lora, Caggiano, Anthony O., King, Declan, Gobbo, Francesco, Davies, Caitlin, Hooley, Monique, Dunnett, Sophie, Tempelaar, Robert, Meftah, Soraya, Tzioras, Makis, Hamby, Mary E., Izzo, Nicholas J., Catalano, Susan M., Durrant, Claire S., Smith, Colin, Dando, Owen, Spires-Jones, Tara L.
Published in Acta neuropathologica (01.06.2024)
Published in Acta neuropathologica (01.06.2024)
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Discovery of Investigational Drug CT1812, an Antagonist of the Sigma‑2 Receptor Complex for Alzheimer’s Disease
Rishton, Gilbert M, Look, Gary C, Ni, Zhi-Jie, Zhang, Jason, Wang, Yingcai, Huang, Yaodong, Wu, Xiaodong, Izzo, Nicholas J, LaBarbera, Kelsie M, Limegrover, Colleen S, Rehak, Courtney, Yurko, Raymond, Catalano, Susan M
Published in ACS medicinal chemistry letters (09.09.2021)
Published in ACS medicinal chemistry letters (09.09.2021)
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Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands
Xu, Kuiying, Hsieh, Chia-Ju, Lee, Ji Youn, Riad, Aladdin, Izzo, Nicholas J., Look, Gary, Catalano, Susan, Mach, Robert H.
Published in International journal of molecular sciences (27.07.2022)
Published in International journal of molecular sciences (27.07.2022)
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A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer's disease
van Dyck, Christopher H, Mecca, Adam P, O'Dell, Ryan S, Bartlett, Hugh H, Diepenbrock, Nina G, Huang, Yiyun, Hamby, Mary E, Grundman, Michael, Catalano, Susan M, Caggiano, Anthony O, Carson, Richard E
Published in Alzheimer's research & therapy (25.01.2024)
Published in Alzheimer's research & therapy (25.01.2024)
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Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease
Izzo, Nicholas J, Colom-Cadena, Martí, Riad, Aladdin A, Xu, Jinbin, Singh, Meharvan, Abate, Carmen, Cahill, Michael A, Spires-Jones, Tara L, Bowen, Wayne D, Mach, Robert H, Catalano, Susan M
Published in eNeuro (01.11.2020)
Published in eNeuro (01.11.2020)
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Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification
Izzo, Nicholas J., Yuede, Carla M., LaBarbera, Kelsie M., Limegrover, Colleen S., Rehak, Courtney, Yurko, Raymond, Waybright, Lora, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Hamby, Mary E., Williams, Claire, Sadlek, Kelsey, Edwards, Hannah M., Davis, Charles S., Grundman, Michael, Schneider, Lon S., DeKosky, Steven T., Chelsky, Daniel, Pike, Ian, Henstridge, Christopher, Blennow, Kaj, Zetterberg, Henrik, LeVine, Harry, Spires‐Jones, Tara L., Cirrito, John R., Catalano, Susan M.
Published in Alzheimer's & dementia (01.08.2021)
Published in Alzheimer's & dementia (01.08.2021)
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Activity-Dependent Cortical Target Selection by Thalamic Axons
Catalano, Susan M., Shatz, Carla J.
Published in Science (American Association for the Advancement of Science) (24.07.1998)
Published in Science (American Association for the Advancement of Science) (24.07.1998)
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Netrin-1 Promotes Thalamic Axon Growth and Is Required for Proper Development of the Thalamocortical Projection
Braisted, Janet E, Catalano, Susan M, Stimac, Robert, Kennedy, Timothy E, Tessier-Lavigne, Marc, Shatz, Carla J, O'Leary, Dennis D. M
Published in The Journal of neuroscience (01.08.2000)
Published in The Journal of neuroscience (01.08.2000)
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Discovery of ADDL--targeting small molecule drugs for Alzheimer's disease
Look, Gary C, Jerecic, Jasna, Cherbavaz, Diana B, Pray, Todd R, Breach, Jean-Claude R, Crosier, Walter J, Igoudin, Lev, Hironaka, Catherine M, Lowe, Raymond M, McEntee, Michele, Ruslim-Litrus, Lily, Wu, Hsiu-Mei, Zhang, Sue, Catalano, Susan M, Goure, William F, Summa, David, Krafft, Grant A
Published in Current Alzheimer research (01.12.2007)
Published in Current Alzheimer research (01.12.2007)
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