Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
Fang, Mark Y., Markmiller, Sebastian, Vu, Anthony Q., Javaherian, Ashkan, Dowdle, William E., Jolivet, Philippe, Bushway, Paul J., Castello, Nicholas A., Baral, Ashmita, Chan, Michelle Y., Linsley, Jeremy W., Linsley, Drew, Mercola, Mark, Finkbeiner, Steven, Lecuyer, Eric, Lewcock, Joseph W., Yeo, Gene W.
Published in Neuron (Cambridge, Mass.) (04.09.2019)
Published in Neuron (Cambridge, Mass.) (04.09.2019)
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Journal Article
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
Blurton-Jones, Mathew, Kitazawa, Masashi, Martinez-Coria, Hilda, Castello, Nicholas A, Müller, Franz-Josef, Loring, Jeanne F, Yamasaki, Tritia R, Poon, Wayne W, Green, Kim N, LaFerla, Frank M
Published in Proceedings of the National Academy of Sciences - PNAS (11.08.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (11.08.2009)
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Journal Article
7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss
Castello, Nicholas A, Nguyen, Michael H, Tran, Jenny D, Cheng, David, Green, Kim N, LaFerla, Frank M
Published in PloS one (10.03.2014)
Published in PloS one (10.03.2014)
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Journal Article
Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease
Chabrier, Meredith A, Cheng, David, Castello, Nicholas A, Green, Kim N, LaFerla, Frank M
Published in Neurobiology of disease (01.04.2014)
Published in Neurobiology of disease (01.04.2014)
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Journal Article
Correction: Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models
Blurton-Jones, Mathew, Spencer, Brian, Michael, Sara, Castello, Nicholas A, Agazaryan, Andranik A, Davis, Joy L, Müller, Franz-Josef, Loring, Jeanne F, Masliah, Eliezer, LaFerla, Frank M
Published in Stem cell research & therapy (25.03.2024)
Published in Stem cell research & therapy (25.03.2024)
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Journal Article
Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity
Czirr, Eva, Castello, Nicholas A, Mosher, Kira I, Castellano, Joseph M, Hinkson, Izumi V, Lucin, Kurt M, Baeza-Raja, Bernat, Ryu, Jae Kyu, Li, Lulin, Farina, Sasha N, Belichenko, Nadia P, Longo, Frank M, Akassoglou, Katerina, Britschgi, Markus, Cirrito, John R, Wyss-Coray, Tony
Published in The Journal of experimental medicine (03.04.2017)
Published in The Journal of experimental medicine (03.04.2017)
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Journal Article
α7 Nicotinic Receptor Agonist Enhances Cognition in Aged 3xTg-AD Mice with Robust Plaques and Tangles
Medeiros, Rodrigo, Castello, Nicholas A, Cheng, David, Kitazawa, Masashi, Baglietto-Vargas, David, Green, Kim N, Esbenshade, Timothy A, Bitner, Robert S, Decker, Michael W, LaFerla, Frank M
Published in The American journal of pathology (01.02.2014)
Published in The American journal of pathology (01.02.2014)
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Journal Article
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models
Blurton-Jones, Mathew, Spencer, Brian, Michael, Sara, Castello, Nicholas A, Agazaryan, Andranik A, Davis, Joy L, Müller, Franz-Josef, Loring, Jeanne F, Masliah, Eliezer, LaFerla, Frank M
Published in Stem cell research & therapy (16.04.2014)
Published in Stem cell research & therapy (16.04.2014)
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Journal Article
Superhuman cell death detection with biomarker-optimized neural networks
Linsley, Jeremy W, Linsley, Drew A, Lamstein, Josh, Ryan, Gennadi, Shah, Kevan, Castello, Nicholas A, Oza, Viral, Kalra, Jaslin, Wang, Shijie, Tokuno, Zachary, Javaherian, Ashkan, Serre, Thomas, Finkbeiner, Steven
Published in Science advances (10.12.2021)
Published in Science advances (10.12.2021)
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Journal Article
In vivo optical signatures of neuronal death in a mouse model of Alzheimer's disease
Lin, Alexander J., Castello, Nicholas A., Lee, Grace, Green, Kim N., Durkin, Anthony J., Choi, Bernard, LaFerla, Frank, Tromberg, Bruce J.
Published in Lasers in surgery and medicine (01.01.2014)
Published in Lasers in surgery and medicine (01.01.2014)
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Journal Article
Optical imaging in an Alzheimer's mouse model reveals amyloid-β-dependent vascular impairment
Lin, Alexander J, Liu, Gangjun, Castello, Nicholas A, Yeh, James J, Rahimian, Rombod, Lee, Grace, Tsay, Victoria, Durkin, Anthony J, Choi, Bernard, LaFerla, Frank M, Chen, Zhongping, Green, Kim N, Tromberg, Bruce J
Published in Neurophotonics (Print) (01.07.2014)
Published in Neurophotonics (Print) (01.07.2014)
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Journal Article
Using neural stem cells to promote plasticity and improve cognition in transgenic AD mice
Blurton-Jones, Mathew, Kitazawa, Masashi, Martinez-Coria, Hilda, Castello, Nicholas A, Muller, Franz-Joseph, Loring, Jeanne F, Poon, Wayne W, Green, Kim, LaFerla, Frank M
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
O1‐04‐01: Using neural stem cells to promote plasticity and improve cognition in transgenic AD mice
Blurton-Jones, Mathew, Kitazawa, Masashi, Martinez-Coria, Hilda, Castello, Nicholas A., Muller, Franz-Joseph, Loring, Jeanne F., Poon, Wayne W., Green, Kim, LaFerla, Frank M.
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
Super-human cell death detection with biomarker-optimized neural networks
Linsley, Jeremy W, Linsley, Drew, Lamstein, Josh, Ryan, Gennadi, Shah, Kevan, Castello, Nicholas A, Oza, Viral, Kalra, Jaslin, Wang, Shijie, Tokuno, Zachary, Javaherian, Ashkan, Serre, Thomas, Finkbeiner, Steve
Published in bioRxiv (07.06.2021)
Published in bioRxiv (07.06.2021)
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Paper
Chapter 1 - The Contribution of Transgenic Models to the Understanding of Alzheimer's Disease Progression and Therapeutic Development
Chabrier, Meredith A., Neely, Kara M., Castello, Nicholas A., LaFerla, Frank M.
Published in Animal Models for Neurodegenerative Disease (2011)
Published in Animal Models for Neurodegenerative Disease (2011)
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Book Chapter