Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved
Martínez-Sena, Teresa, Moro, Erika, Moreno-Torres, Marta, Quintás, Guillermo, Hengstler, Jan, Castell, José V.
Published in Archives of toxicology (01.06.2023)
Published in Archives of toxicology (01.06.2023)
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Journal Article
The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics
Quintás, Guillermo, Castell, José V, Moreno-Torres, Marta
Published in Frontiers in pharmacology (05.05.2023)
Published in Frontiers in pharmacology (05.05.2023)
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Journal Article
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes
Moreno-Torres, Marta, Kumar, Manoj, García-Llorens, Guillem, Quintás, Guillermo, Tricot, Tine, Boon, Ruben, Tolosa, Laia, Toprakhisar, Burak, Chesnais, Francois, Verfaillie, Catherine, Castell, José V
Published in Journal of proteome research (04.03.2022)
Published in Journal of proteome research (04.03.2022)
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Journal Article
Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat
Quintás, Guillermo, Caiment, Florian, Rienda, Iván, Pérez-Rojas, Judith, Pareja, Eugenia, Castell, José V, Jover, Ramiro
Published in International journal of molecular sciences (18.08.2022)
Published in International journal of molecular sciences (18.08.2022)
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Journal Article
Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile
Moya, Marta, José Gómez-Lechón, M., Castell, José V., Jover, Ramiro
Published in Chemico-biological interactions (30.03.2010)
Published in Chemico-biological interactions (30.03.2010)
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A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients
Baier, Vanessa, Cordes, Henrik, Thiel, Christoph, Castell, José V., Neumann, Ulf P., Blank, Lars M., Kuepfer, Lars
Published in Frontiers in physiology (27.09.2019)
Published in Frontiers in physiology (27.09.2019)
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Journal Article
Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC–MS Metabolomics
Ten-Doménech, Isabel, Martínez-Sena, Teresa, Moreno-Torres, Marta, Sanjuan-Herráez, Juan Daniel, Castell, José V., Parra-Llorca, Anna, Vento, Máximo, Quintás, Guillermo, Kuligowski, Julia
Published in Metabolites (26.03.2020)
Published in Metabolites (26.03.2020)
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CCAAT/Enhancer-binding Protein α (C/EBPα) and Hepatocyte Nuclear Factor 4α (HNF4α) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene: APPLICATION TO THE DEVELOPMENT OF A METABOLICALLY COMPETENT HUMAN HEPATIC CELL MODEL
Benet, Marta, Lahoz, Agustín, Guzmán, Carla, Castell, José V, Jover, Ramiro
Published in The Journal of biological chemistry (10.09.2010)
Published in The Journal of biological chemistry (10.09.2010)
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Journal Article
Underexpressed Coactivators PGC1α AND SRC1 Impair Hepatocyte Nuclear Factor 4α Function and Promote Dedifferentiation in Human Hepatoma Cells
Martínez-Jiménez, Celia P., Gómez-Lechón, M. José, Castell, José V., Jover, Ramiro
Published in The Journal of biological chemistry (06.10.2006)
Published in The Journal of biological chemistry (06.10.2006)
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Journal Article
The use of hepatocytes to investigate drug toxicity
Gómez-Lechón, María José, Castell, José V, Donato, María Teresa
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2010)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2010)
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ATF5 Is a Highly Abundant Liver-Enriched Transcription Factor that Cooperates with Constitutive Androstane Receptor in the Transactivation of CYP2B6: Implications in Hepatic Stress Responses
PASCUAL, Maya, GOMEZ-LECHON, M. Jose, CASTELL, José V, JOVER, Ramiro
Published in Drug metabolism and disposition (01.06.2008)
Published in Drug metabolism and disposition (01.06.2008)
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Journal Article
Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach
Castell, José V., Teresa Donato, M., Gómez-Lechón, María José
Published in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie (01.07.2005)
Published in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie (01.07.2005)
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Journal Article
Allergic hepatitis induced by drugs
Castell, José V, Castell, Marta
Published in Current opinion in allergy and clinical immunology (01.08.2006)
Published in Current opinion in allergy and clinical immunology (01.08.2006)
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Journal Article
A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy
Soluyanova, Polina, Del Pozo, Marta, Moro-Castaño, Erika, Marco-Hernandez, Ana V, Castell, José V, Jover, Ramiro
Published in Toxicology (Amsterdam) (16.10.2024)
Published in Toxicology (Amsterdam) (16.10.2024)
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