Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches
Ortega-Vallbona, Rita, Méndez, Rebeca, Tolosa, Laia, Escher, Sylvia E., Castell, José V., Gozalbes, Rafael, Serrano-Candelas, Eva
Published in Toxicology (Amsterdam) (01.05.2024)
Published in Toxicology (Amsterdam) (01.05.2024)
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Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved
Martínez-Sena, Teresa, Moro, Erika, Moreno-Torres, Marta, Quintás, Guillermo, Hengstler, Jan, Castell, José V.
Published in Archives of toxicology (01.06.2023)
Published in Archives of toxicology (01.06.2023)
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A Novel MicroRNA Signature for Cholestatic Drugs in Human Hepatocytes and Its Translation into Novel Circulating Biomarkers for Drug-Induced Liver Injury Patients
López-Riera, Mireia, Conde, Isabel, Castell, José V, Jover, Ramiro
Published in Toxicological sciences (01.02.2020)
Published in Toxicological sciences (01.02.2020)
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The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics
Quintás, Guillermo, Castell, José V, Moreno-Torres, Marta
Published in Frontiers in pharmacology (05.05.2023)
Published in Frontiers in pharmacology (05.05.2023)
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Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells
Taléns-Visconti, Raquel, Bonora, Ana, Jover, Ramiro, Mirabet, Vicente, Carbonell, Francisco, Castell, José-Vicente, Gómez-Lechón, María José
Published in World journal of gastroenterology : WJG (28.09.2006)
Published in World journal of gastroenterology : WJG (28.09.2006)
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A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non‐Alcoholic Fatty Liver Disease
Petrov, Petar Dianov, García‐Mediavilla, Maria Victoria, Guzmán, Carla, Porras, David, Nistal, Esther, Martínez‐Flórez, Susana, Castell, José Vicente, González‐Gallego, Javier, Sánchez‐Campos, Sonia, Jover, Ramiro
Published in Molecular nutrition & food research (01.10.2019)
Published in Molecular nutrition & food research (01.10.2019)
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Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey
Moreno-Torres, Marta, García-Llorens, Guillem, Moro, Erika, Méndez, Rebeca, Quintás, Guillermo, Castell, José Vicente
Published in Scientific reports (11.11.2021)
Published in Scientific reports (11.11.2021)
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The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes
Martínez-Sena, Teresa, Soluyanova, Polina, Guzmán, Carla, Valdivielso, José Manuel, Castell, José Vicente, Jover, Ramiro
Published in Biomolecules (Basel, Switzerland) (24.03.2020)
Published in Biomolecules (Basel, Switzerland) (24.03.2020)
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Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Albrecht, Wiebke, Kappenberg, Franziska, Brecklinghaus, Tim, Stoeber, Regina, Marchan, Rosemarie, Zhang, Mian, Ebbert, Kristina, Kirschner, Hendrik, Grinberg, Marianna, Leist, Marcel, Moritz, Wolfgang, Cadenas, Cristina, Ghallab, Ahmed, Reinders, Jörg, Vartak, Nachiket, van Thriel, Christoph, Golka, Klaus, Tolosa, Laia, Castell, José V., Damm, Georg, Seehofer, Daniel, Lampen, Alfonso, Braeuning, Albert, Buhrke, Thorsten, Behr, Anne-Cathrin, Oberemm, Axel, Gu, Xiaolong, Kittana, Naim, van de Water, Bob, Kreiling, Reinhard, Fayyaz, Susann, van Aerts, Leon, Smedsrød, Bård, Ellinger-Ziegelbauer, Heidrun, Steger-Hartmann, Thomas, Gundert-Remy, Ursula, Zeigerer, Anja, Ullrich, Anett, Runge, Dieter, Lee, Serene M. L., Schiergens, Tobias S., Kuepfer, Lars, Aguayo-Orozco, Alejandro, Sachinidis, Agapios, Edlund, Karolina, Gardner, Iain, Rahnenführer, Jörg, Hengstler, Jan G.
Published in Archives of toxicology (01.06.2019)
Published in Archives of toxicology (01.06.2019)
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Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile
Moya, Marta, José Gómez-Lechón, M., Castell, José V., Jover, Ramiro
Published in Chemico-biological interactions (30.03.2010)
Published in Chemico-biological interactions (30.03.2010)
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Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC–MS Metabolomics
Ten-Doménech, Isabel, Martínez-Sena, Teresa, Moreno-Torres, Marta, Sanjuan-Herráez, Juan Daniel, Castell, José V., Parra-Llorca, Anna, Vento, Máximo, Quintás, Guillermo, Kuligowski, Julia
Published in Metabolites (26.03.2020)
Published in Metabolites (26.03.2020)
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Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver
Moya, Marta, Benet, Marta, Guzmán, Carla, Tolosa, Laia, García-Monzón, Carmelo, Pareja, Eugenia, Castell, José Vicente, Jover, Ramiro
Published in PloS one (06.01.2012)
Published in PloS one (06.01.2012)
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Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes
Petrov, Petar D., Fernández-Murga, Leonor, Conde, Isabel, Martínez-Sena, Teresa, Guzmán, Carla, Castell, José Vicente, Jover, Ramiro
Published in Archives of toxicology (01.02.2020)
Published in Archives of toxicology (01.02.2020)
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Journal Article
New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease
López-Riera, Mireia, Conde, Isabel, Tolosa, Laia, Zaragoza, Ángela, Castell, José V, Gómez-Lechón, María J, Jover, Ramiro
Published in Frontiers in pharmacology (25.01.2017)
Published in Frontiers in pharmacology (25.01.2017)
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The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARα; and repressed by C/EBPα: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease
Guzmán, Carla, Benet, Marta, Pisonero-Vaquero, Sandra, Moya, Marta, García-Mediavilla, M. Victoria, Martínez-Chantar, M. Luz, González-Gallego, Javier, Castell, José Vicente, Sánchez-Campos, Sonia, Jover, Ramiro
Published in Biochimica et biophysica acta (01.04.2013)
Published in Biochimica et biophysica acta (01.04.2013)
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A simple transcriptomic signature able to predict drug-induced hepatic steatosis
Benet, Marta, Moya, Marta, Donato, M. Teresa, Lahoz, Agustín, Hervás, David, Guzmán, Carla, Gómez-Lechón, M. José, Castell, José Vicente, Jover, Ramiro
Published in Archives of toxicology (01.04.2014)
Published in Archives of toxicology (01.04.2014)
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