The novel low molecular weight MYC antagonist MYCMI-6 inhibits proliferation and induces apoptosis in breast cancer cells
AlSultan, Dalal, Kavanagh, Emma, O’Grady, Shane, Eustace, Alex J, Castell, Alina, Larsson, Lars-Gunnar, Crown, John, Madden, Stephen F, Duffy, Michael J
Published in Investigational new drugs (01.04.2021)
Published in Investigational new drugs (01.04.2021)
Get full text
Journal Article
The F-Box Protein Skp2 Participates in c-Myc Proteosomal Degradation and Acts as a Cofactor for c-Myc-Regulated Transcription
von der Lehr, Natalie, Johansson, Sara, Wu, Siqin, Bahram, Fuad, Castell, Alina, Cetinkaya, Cihan, Hydbring, Per, Weidung, Ingrid, Nakayama, Keiko, Nakayama, Keiichi I, Söderberg, Ola, Kerppola, Tom K, Larsson, Lars-Gunnar
Published in Molecular cell (01.05.2003)
Published in Molecular cell (01.05.2003)
Get full text
Journal Article
Structure and function of Rv0130, a conserved hypothetical protein from Mycobacterium tuberculosis
Johansson, Patrik, Castell, Alina, Jones, T. Alwyn, Bäckbro, Kristina
Published in Protein science (01.10.2006)
Published in Protein science (01.10.2006)
Get full text
Journal Article
A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation
Castell, Alina, Yan, Qinzi, Fawkner, Karin, Hydbring, Per, Zhang, Fan, Verschut, Vasiliki, Franco, Marcela, Zakaria, Siti Mariam, Bazzar, Wesam, Goodwin, Jacob, Zinzalla, Giovanna, Larsson, Lars-Gunnar
Published in Scientific reports (03.07.2018)
Published in Scientific reports (03.07.2018)
Get full text
Journal Article
Abstract 3952: Selective high affinity MYC-binding compound inhibits MYC-MAX interaction and MYC-dependent tumor cell growth
Castell, Alina, Yan, Qinzi, Fawkner, Karin, Hydbring, Per, Zhang, Fan, Verschut, Vasiliki, Franco, Marcela, Zinzalla, Giovanna, Larsson, Lars-Gunnar
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts
Zhang, Fan, Zakaria, Siti Mariam, Högqvist Tabor, Vedrana, Singh, Madhurendra, Tronnersjö, Susanna, Goodwin, Jacob, Selivanova, Galina, Bartek, Jiri, Castell, Alina, Larsson, Lars-Gunnar
Published in Cell cycle (Georgetown, Tex.) (17.12.2018)
Published in Cell cycle (Georgetown, Tex.) (17.12.2018)
Get full text
Journal Article
Abstract 1227: New small molecules targeting MYC:MAX interactions that inhibits tumor cell growth in a MYC-dependent manner
Castell, Alina, Ridderstråle, Karin, Yan, Qinzi, Zhang, Fan, Hydbring, Per, Franco, Marcela, Goodwin, Jacob, Müller, Inga, Zakaria, Siti Mariam, Johansson, Lars, Larsson, Lars-Gunnar
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site
Cookson, Tammie V. M, Evans, Genevieve L, Castell, Alina, Baker, Edward N, Lott, J. Shaun, Parker, Emily J
Published in Biochemistry (Easton) (06.10.2015)
Published in Biochemistry (Easton) (06.10.2015)
Get full text
Journal Article
Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis
Cookson, Tammie V M, Castell, Alina, Bulloch, Esther M M, Evans, Genevieve L, Short, Francesca L, Baker, Edward N, Lott, J Shaun, Parker, Emily J
Published in Biochemical journal (01.07.2014)
Published in Biochemical journal (01.07.2014)
Get more information
Journal Article
MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
Castell, Alina, Yan, Qinzi, Fawkner, Karin, Bazzar, Wesam, Zhang, Fan, Wickström, Malin, Alzrigat, Mohammad, Franco, Marcela, Krona, Cecilia, Cameron, Donald P, Dyberg, Cecilia, Olsen, Thale Kristin, Verschut, Vasiliki, Schmidt, Linnéa, Lim, Sheryl Y, Mahmoud, Loay, Hydbring, Per, Lehmann, Sören, Baranello, Laura, Nelander, Sven, Johnsen, John Inge, Larsson, Lars-Gunnar
Published in Cancer research communications (01.03.2022)
Published in Cancer research communications (01.03.2022)
Get full text
Journal Article
The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition
Castell, Alina, Short, Francesca L, Evans, Genevieve L, Cookson, Tammie V. M, Bulloch, Esther M. M, Joseph, Dmitri D. A, Lee, Clare E, Parker, Emily J, Baker, Edward N, Lott, J. Shaun
Published in Biochemistry (Easton) (12.03.2013)
Published in Biochemistry (Easton) (12.03.2013)
Get full text
Journal Article
Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation
Bahram, Fuad, Hydbring, Per, Tronnersjö, Susanna, Zakaria, Siti Mariam, Frings, Oliver, Fahlén, Sara, Nilsson, Helén, Goodwin, Jacob, von der Lehr, Natalie, Su, Yingtao, Lüscher, Bernhard, Castell, Alina, Larsson, Lars-Gunnar
Published in Oncotarget (19.01.2016)
Published in Oncotarget (19.01.2016)
Get full text
Journal Article
Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex
Bashiri, Ghader, Johnston, Jodie M., Evans, Genevieve L., Bulloch, Esther M. M., Goldstone, David C., Jirgis, Ehab N. M., Kleinboelting, Silke, Castell, Alina, Ramsay, Rochelle J., Manos-Turvey, Alexandra, Payne, Richard J., Lott, J. Shaun, Baker, Edward N.
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2015)
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2015)
Get full text
Journal Article
Web Resource
Rv0216, a conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdog fold
Castell, Alina, Johansson, Patrik, Unge, Torsten, Jones, T. Alwyn, Bäckbro, Kristina
Published in Protein science (01.07.2005)
Published in Protein science (01.07.2005)
Get full text
Journal Article