Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections
Guo, Dong-chuan, Regalado, Ellen, Casteel, Darren E., Santos-Cortez, Regie L., Gong, Limin, Kim, Jeong Joo, Dyack, Sarah, Horne, S. Gabrielle, Chang, Guijuan, Jondeau, Guillaume, Boileau, Catherine, Coselli, Joseph S., Li, Zhenyu, Leal, Suzanne M., Shendure, Jay, Rieder, Mark J., Bamshad, Michael J., Nickerson, Deborah A., Kim, Choel, Milewicz, Dianna M.
Published in American journal of human genetics (08.08.2013)
Published in American journal of human genetics (08.08.2013)
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Journal Article
Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor
Kalyanaraman, Hema, Schwappacher, Raphaela, Joshua, Jisha, Zhuang, Shunhui, Scott, Brian T, Klos, Matthew, Casteel, Darren E, Frangos, John A, Dillmann, Wolfgang, Boss, Gerry R, Pilz, Renate B
Published in Science signaling (20.05.2014)
Published in Science signaling (20.05.2014)
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Journal Article
Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog
Schwaerzer, Gerburg K., Kalyanaraman, Hema, Casteel, Darren E., Dalton, Nancy D., Gu, Yusu, Lee, Seunghoe, Zhuang, Shunhui, Wahwah, Nisreen, Schilling, Jan M., Patel, Hemal H., Zhang, Qian, Makino, Ayako, Milewicz, Dianna M., Peterson, Kirk L., Boss, Gerry R., Pilz, Renate B.
Published in Nature communications (06.08.2019)
Published in Nature communications (06.08.2019)
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Journal Article
Correction to: Crystal structure of PKG Iβ holoenzyme reveals a trans‑inhibiting dimer assembly
Kim, Choel, Sharma, Rajesh, Casteel, Darren E
Published in Journal of translational medicine (16.01.2020)
Published in Journal of translational medicine (16.01.2020)
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Journal Article
Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I
Huang, Gilbert Y., Kim, Jeong Joo, Reger, Albert S., Lorenz, Robin, Moon, Eui-Whan, Zhao, Chi, Casteel, Darren E., Bertinetti, Daniela, VanSchouwen, Bryan, Selvaratnam, Rajeevan, Pflugrath, James W., Sankaran, Banumathi, Melacini, Giuseppe, Herberg, Friedrich W., Kim, Choel
Published in Structure (London) (07.01.2014)
Published in Structure (London) (07.01.2014)
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Journal Article
Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation
Kim, Jeong Joo, Lorenz, Robin, Arold, Stefan T., Reger, Albert S., Sankaran, Banumathi, Casteel, Darren E., Herberg, Friedrich W., Kim, Choel
Published in Structure (London) (03.05.2016)
Published in Structure (London) (03.05.2016)
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Journal Article
cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss
Ramdani, Ghania, Schall, Nadine, Kalyanaraman, Hema, Wahwah, Nisreen, Moheize, Sahar, Lee, Jenna J, Sah, Robert L, Pfeifer, Alexander, Casteel, Darren E, Pilz, Renate B
Published in Journal of endocrinology (01.09.2018)
Published in Journal of endocrinology (01.09.2018)
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Journal Article
An auto-inhibited state of protein kinase G and implications for selective activation
Sharma, Rajesh, Kim, Jeong Joo, Qin, Liying, Henning, Philipp, Akimoto, Madoka, VanSchouwen, Bryan, Kaur, Gundeep, Sankaran, Banumathi, MacKenzie, Kevin R, Melacini, Giuseppe, Casteel, Darren E, Herberg, Friedrich W, Kim, Choel
Published in eLife (05.08.2022)
Published in eLife (05.08.2022)
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Journal Article
Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication
Osborne, Brent W., Wu, Jian, McFarland, Caitlin J., Nickl, Christian K., Sankaran, Banumathi, Casteel, Darren E., Woods, Virgil L., Kornev, Alexandr P., Taylor, Susan S., Dostmann, Wolfgang R.
Published in Structure (London) (07.09.2011)
Published in Structure (London) (07.09.2011)
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Journal Article
Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts
Rangaswami, Hema, Schwappacher, Raphaela, Marathe, Nisha, Zhuang, Shunhui, Casteel, Darren E, Haas, Bodo, Chen, Yong, Pfeifer, Alexander, Kato, Hisashi, Shattil, Sanford, Boss, Gerry R, Pilz, Renate B
Published in Science signaling (21.12.2010)
Published in Science signaling (21.12.2010)
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Journal Article
Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions
Reger, Albert S., Yang, Matthew P., Koide-Yoshida, Shizuyo, Guo, Elaine, Mehta, Shrenik, Yuasa, Keizo, Liu, Alan, Casteel, Darren E., Kim, Choel
Published in The Journal of biological chemistry (12.09.2014)
Published in The Journal of biological chemistry (12.09.2014)
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Journal Article
Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding
Kim, Jeong Joo, Casteel, Darren E, Huang, Gilbert, Kwon, Taek Hun, Ren, Ronnie Kuo, Zwart, Peter, Headd, Jeffrey J, Brown, Nicholas Gene, Chow, Dar-Chone, Palzkill, Timothy, Kim, Choel
Published in PloS one (19.04.2011)
Published in PloS one (19.04.2011)
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Journal Article
Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3
Hu, Tingfei, Kalyanaraman, Hema, Pilz, Renate B., Casteel, Darren E.
Published in The Journal of biological chemistry (01.04.2023)
Published in The Journal of biological chemistry (01.04.2023)
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Journal Article
PKGIα is activated by metal-dependent oxidation in vitro but not in intact cells
Aminzai, Sahar, Hu, Tingfei, Pilz, Renate B., Casteel, Darren E.
Published in The Journal of biological chemistry (01.08.2022)
Published in The Journal of biological chemistry (01.08.2022)
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Journal Article
Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes
Kalyanaraman, Hema, Schwaerzer, Gerburg, Ramdani, Ghania, Castillo, Francine, Scott, Brian T, Dillmann, Wolfgang, Sah, Robert L, Casteel, Darren E, Pilz, Renate B
Published in Diabetes (New York, N.Y.) (01.04.2018)
Published in Diabetes (New York, N.Y.) (01.04.2018)
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Journal Article
A plasma membrane-associated form of the androgen receptor enhances nuclear androgen signaling in osteoblasts and prostate cancer cells
Kalyanaraman, Hema, Casteel, Darren E, China, Shyamsundar Pal, Zhuang, Shunhui, Boss, Gerry R, Pilz, Renate B
Published in Science signaling (30.01.2024)
Published in Science signaling (30.01.2024)
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