Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections
Guo, Dong-chuan, Regalado, Ellen, Casteel, Darren E., Santos-Cortez, Regie L., Gong, Limin, Kim, Jeong Joo, Dyack, Sarah, Horne, S. Gabrielle, Chang, Guijuan, Jondeau, Guillaume, Boileau, Catherine, Coselli, Joseph S., Li, Zhenyu, Leal, Suzanne M., Shendure, Jay, Rieder, Mark J., Bamshad, Michael J., Nickerson, Deborah A., Kim, Choel, Milewicz, Dianna M.
Published in American journal of human genetics (08.08.2013)
Published in American journal of human genetics (08.08.2013)
Get full text
Journal Article
Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3
Hu, Tingfei, Kalyanaraman, Hema, Pilz, Renate B., Casteel, Darren E.
Published in The Journal of biological chemistry (01.04.2023)
Published in The Journal of biological chemistry (01.04.2023)
Get full text
Journal Article
PKGIα is activated by metal-dependent oxidation in vitro but not in intact cells
Aminzai, Sahar, Hu, Tingfei, Pilz, Renate B., Casteel, Darren E.
Published in The Journal of biological chemistry (01.08.2022)
Published in The Journal of biological chemistry (01.08.2022)
Get full text
Journal Article
Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I
Huang, Gilbert Y., Kim, Jeong Joo, Reger, Albert S., Lorenz, Robin, Moon, Eui-Whan, Zhao, Chi, Casteel, Darren E., Bertinetti, Daniela, VanSchouwen, Bryan, Selvaratnam, Rajeevan, Pflugrath, James W., Sankaran, Banumathi, Melacini, Giuseppe, Herberg, Friedrich W., Kim, Choel
Published in Structure (London) (07.01.2014)
Published in Structure (London) (07.01.2014)
Get full text
Journal Article
Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes
Kalyanaraman, Hema, Schwaerzer, Gerburg, Ramdani, Ghania, Castillo, Francine, Scott, Brian T, Dillmann, Wolfgang, Sah, Robert L, Casteel, Darren E, Pilz, Renate B
Published in Diabetes (New York, N.Y.) (01.04.2018)
Published in Diabetes (New York, N.Y.) (01.04.2018)
Get full text
Journal Article
A plasma membrane-associated form of the androgen receptor enhances nuclear androgen signaling in osteoblasts and prostate cancer cells
Kalyanaraman, Hema, Casteel, Darren E, China, Shyamsundar Pal, Zhuang, Shunhui, Boss, Gerry R, Pilz, Renate B
Published in Science signaling (30.01.2024)
Published in Science signaling (30.01.2024)
Get more information
Journal Article
A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice
Kalyanaraman, Hema, Ramdani, Ghania, Joshua, Jisha, Schall, Nadine, Boss, Gerry R, Cory, Esther, Sah, Robert L, Casteel, Darren E, Pilz, Renate B
Published in Journal of bone and mineral research (01.01.2017)
Published in Journal of bone and mineral research (01.01.2017)
Get full text
Journal Article
A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP
Chan, Matthew H., Aminzai, Sahar, Hu, Tingfei, Taran, Amatya, Li, Sheng, Kim, Choel, Pilz, Renate B., Casteel, Darren E.
Published in The Journal of biological chemistry (24.07.2020)
Published in The Journal of biological chemistry (24.07.2020)
Get full text
Journal Article
Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor
Kalyanaraman, Hema, Schwappacher, Raphaela, Joshua, Jisha, Zhuang, Shunhui, Scott, Brian T, Klos, Matthew, Casteel, Darren E, Frangos, John A, Dillmann, Wolfgang, Boss, Gerry R, Pilz, Renate B
Published in Science signaling (20.05.2014)
Published in Science signaling (20.05.2014)
Get more information
Journal Article
Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog
Schwaerzer, Gerburg K., Kalyanaraman, Hema, Casteel, Darren E., Dalton, Nancy D., Gu, Yusu, Lee, Seunghoe, Zhuang, Shunhui, Wahwah, Nisreen, Schilling, Jan M., Patel, Hemal H., Zhang, Qian, Makino, Ayako, Milewicz, Dianna M., Peterson, Kirk L., Boss, Gerry R., Pilz, Renate B.
Published in Nature communications (06.08.2019)
Published in Nature communications (06.08.2019)
Get full text
Journal Article
Bladder Cancer Invasion Is Mediated by Mammalian Target of Rapamycin Complex 2–Driven Regulation of Nitric Oxide and Invadopodia Formation
Sahu, Divya, Huan, Jianya, Wang, Huawei, Sahoo, Debashis, Casteel, Darren E., Klemke, Richard L., Boss, Gerry R., Hansel, Donna E.
Published in The American journal of pathology (01.12.2021)
Published in The American journal of pathology (01.12.2021)
Get full text
Journal Article
O-GlcNAcylation of 8-Oxoguanine DNA Glycosylase (Ogg1) Impairs Oxidative Mitochondrial DNA Lesion Repair in Diabetic Hearts
Cividini, Federico, Scott, Brian T., Dai, Anzhi, Han, Wenlong, Suarez, Jorge, Diaz-Juarez, Julieta, Diemer, Tanja, Casteel, Darren E., Dillmann, Wolfgang H.
Published in The Journal of biological chemistry (16.12.2016)
Published in The Journal of biological chemistry (16.12.2016)
Get full text
Journal Article
Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells
Haushalter, Kristofer J., Casteel, Darren E., Raffeiner, Andrea, Stefan, Eduard, Patel, Hemal H., Taylor, Susan S.
Published in The Journal of biological chemistry (23.03.2018)
Published in The Journal of biological chemistry (23.03.2018)
Get full text
Journal Article
Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function
Cividini, Federico, Scott, Brian T, Suarez, Jorge, Casteel, Darren E, Heinz, Sven, Dai, Anzhi, Diemer, Tanja, Suarez, Jorge A, Benner, Christopher W, Ghassemian, Majid, Dillmann, Wolfgang H
Published in Diabetes (New York, N.Y.) (01.03.2021)
Published in Diabetes (New York, N.Y.) (01.03.2021)
Get full text
Journal Article
Correction to: Crystal structure of PKG Iβ holoenzyme reveals a trans‑inhibiting dimer assembly
Kim, Choel, Sharma, Rajesh, Casteel, Darren E
Published in Journal of translational medicine (16.01.2020)
Published in Journal of translational medicine (16.01.2020)
Get full text
Journal Article
Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation
Kim, Jeong Joo, Lorenz, Robin, Arold, Stefan T., Reger, Albert S., Sankaran, Banumathi, Casteel, Darren E., Herberg, Friedrich W., Kim, Choel
Published in Structure (London) (03.05.2016)
Published in Structure (London) (03.05.2016)
Get full text
Journal Article